Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Gálvez-Ontiveros, Yolanda; Páez, Sara; Monteagudo, Celia; Rivas, Ana

doi:10.3390/nu12041158

Cited by 80 publications

(47 citation statements)

References 149 publications

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“…At present, the attention of science in the field of EDs is focused mainly on synthetic industrial chemicals because of the absence of evolutionary adaptation to these xenobiotics [ 129 ]. These are plasticizers and other chemicals present in plastic as well as paper food packaging, which expose the human population to endocrine disruptors through food practically continuously [ 130 ]. This phenomenon has been confirmed by numerous studies, the results of which indicate increased concentrations of bisphenols, alkylphenols, phthalates, and perfluoroalkyl compounds in the saliva, urine, and milk of exposed individuals, but also in the food of daily consumption [ 131 ].…”

Section: Environmental Pollutionmentioning

confidence: 99%

Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Tirpák

Greifová

Lukáč

et al. 2021

Life

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Natural processes along with increased industrial production and the irresponsible behavior of mankind have resulted in environmental pollution. Environmental pollutants can be categorized based on their characteristics and appearance into the following groups: physical, biological, and chemical. Every single one of them represents a serious threat to the male reproductive tract despite the different modes of action. Male gonads and gametes are especially vulnerable to the effect of exogenous factors; therefore, they are considered a reliable indicator of environmental pollution. The impact of xenobiotics or radiation leads to an irreversible impairment of fertility displayed by histological changes, modulated androgen production, or compromised spermatozoa (or germ cells) quality. The present article reviews the exogenous threats, male reproductive system, the mode of action, and overall impact on the reproductive health of humans and animals.

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Section: Environmental Pollutionmentioning

confidence: 99%

Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Tirpák

Greifová

Lukáč

et al. 2021

Life

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“…However, presently, very little is known regarding the molecular mechanisms underlying these triggered obesogenic effects [ 24 ]. Some groups of food xenobiotics or contaminants that have already been considered obesogens and modifiers of gut microbiota are endocrine disruptors [ 25 ]. However, few alternative strategies have been tested by now for counteracting, metabolizing, or neutralizing these xenobiotics and their body effects by appropriate dietary supplementation probiotics BPA [ 26 ]; Parahydroxybenzoate [ 27 ]; Phthalates [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

et al. 2020

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Obesity is a growing health threat worldwide. Administration of probiotics in obesity has also parallelly increased but without any protocolization. We conducted a systematic review exploring the administration pattern of probiotic strains and effective doses for obesity-related disorders according to their capacity of positively modulating key biomarkers and microbiota dysbiosis. Manuscripts targeting probiotic strains and doses administered for obesity-related disorders in clinical studies were sought. MEDLINE, Scopus, Web of Science, and Cochrane Library databases were searched using keywords during the last fifteen years up to April 2020. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. From 549 interventional reports identified, we filtered 171 eligible studies, from which 24 full-text assays were used for calculating intervention total doses (ITD) of specific species and strains administered. Nine of these reports were excluded in the second-step because no specific data on gut microbiota modulation was found. Six clinical trials (CT) and 9 animal clinical studies were retained for analysis of complete outcome prioritized (body mass index (BMI), adiposity parameters, glucose, and plasma lipid biomarkers, and gut hormones). Lactobacillus spp. administered were double compared to Bifidobacterium spp.; Lactobacillus as single or multispecies formulations whereas most Bifidobacteria only through multispecies supplementations. Differential factors were estimated from obese populations’ vs. obesity-induced animals: ITD ratio of 2 × 106 CFU and patterns of administrations of 11.3 weeks to 5.5 weeks, respectively. Estimation of overall probiotics impact from selected CT was performed through a random-effects model to pool effect sizes. Comparisons showed a positive association between the probiotics group vs. placebo on the reduction of BMI, total cholesterol, leptin, and adiponectin. Moreover, negative estimation appeared for glucose (FPG) and CRP. While clinical trials including data for positive modulatory microbiota capacities suggested that high doses of common single and multispecies of Lactobacillus and Bifidobacterium ameliorated key obesity-related parameters, the major limitation was the high variability between studies and lack of standardized protocols. Efforts in solving this problem and searching for next-generation probiotics for obesity-related diseases would highly improve the rational use of probiotics.

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“…In recent decades the harmful effects on human health related the use of BPA in food packaging have raised much controversy [ 64 , 65 ], with a large number of studies dealing with BPA determination in food [ 45 , 66 , 67 , 68 ]. More recently, there has also been an increase in research that focuses not only on BPA but also on BPA analogues, as they have been reported to exhibit similar adverse health effects to BPA [ 27 , 69 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

Presence of Parabens and Bisphenols in Food Commonly Consumed in Spain

Gálvez-Ontiveros

Moscoso-Ruiz

Rodrigo

et al. 2021

Foods

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Given the widespread use of bisphenols and parabens in consumer products, the assessment of their intake is crucial and represents the first step towards the assessment of the potential risks that these compounds may pose to human health. In the present study, a total of 98 samples of food items commonly consumed by the Spanish population were collected from different national supermarkets and grocery stores for the determination of parabens and bisphenols. Our analysis demonstrated that 56 of the 98 food samples contained detectable levels of parabens with limits of quantification (LOQ) between 0.4 and 0.9 ng g−1. The total concentration of parabens (sum of four parabens: ∑parabens) ranged from below the LOQ to 281.7 ng g−1, with a mean value of 73.86 ng g−1. A total of 52% of the samples showed detectable concentrations of bisphenols. Bisphenol A (BPA) was the most frequently detected bisphenol in the food samples analysed, followed by bisphenol S (BPS) and bisphenol E (BPE). Bisphenol AF (BPAF), bisphenol B (BPB) and bisphenol P (BPP) were not found in any of the analysed samples. LOQ for these bisphenols were between 0.4 and 4.0 ng g−1.

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Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases

Cited by 80 publications

References 149 publications

Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

Presence of Parabens and Bisphenols in Food Commonly Consumed in Spain

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