Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Tirpák, Filip; Greifová, Hana; Lukáč, Norbert; Stawarz, Robert; Massányi, Péter

doi:10.3390/life11030213

Cited by 28 publications

(31 citation statements)

References 175 publications

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“…To complete the DOHaD theory, the concept of Paternal Origins of Health and Disease (POHaD) was recently introduced (for review, see [ 13 ]). Reports have shown a decline in sperm quality in the past decades, likely due to environmental expositions or lifestyle factors [ 14 ]. Reproductive disorders are numerous and differ between men and women, the most common being infertility [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Consequences of Paternal Nutrition on Offspring Health and Disease

et al. 2021

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It is well established that the maternal diet during the periconceptional period affects the progeny’s health. A growing body of evidence suggests that the paternal diet also influences disease onset in offspring. For many years, sperm was considered only to contribute half of the progeny’s genome. It now appears that it also plays a crucial role in health and disease in offspring’s adult life. The nutritional status and environmental exposure of fathers during their childhood and/or the periconceptional period have significant transgenerational consequences. This review aims to describe the effects of various human and rodent paternal feeding patterns on progeny’s metabolism and health, including fasting or intermittent fasting, low-protein and folic acid deficient food, and overnutrition in high-fat and high-sugar diets. The impact on pregnancy outcome, metabolic pathways, and chronic disease onset will be described. The biological and epigenetic mechanisms underlying the transmission from fathers to their progeny will be discussed. All these data provide evidence of the impact of paternal nutrition on progeny health which could lead to preventive diet recommendations for future fathers.

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Section: Introductionmentioning

confidence: 99%

Consequences of Paternal Nutrition on Offspring Health and Disease

et al. 2021

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“…Iron in the form of Fe 2+ can induce lipid peroxidation, which alters spermatozoa membranes and produces MDA [54]. DNA damage is strongly related to OS [55,56]. Despite the low concentration of Cd (15.79 µg/kg), the present study suggests its deleterious effect on the spermatozoa.…”

Section: Discussionmentioning

confidence: 55%

Composition of Stallion Seminal Plasma and Its Impact on Oxidative Stress Markers and Spermatozoa Quality

Tirpák

Halo

Tokárová

et al. 2021

Life

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The composition of seminal plasma of individual sires varies and so does the fertilizing ability. Micro and macro elements along with seminal enzymes, hormones, proteins, and lipids contained in seminal plasma are essential for the proper physiological function of spermatozoa. However, elevated levels against the normal physiological values, especially in the case of trace metals, result in the production of reactive oxygen species. The deficiency of antioxidants in the seminal plasma that could scavenge free radicals causes an impairment of spermatozoa quality. Ejaculates were obtained from 19 stallions. The fresh semen was analyzed to evaluate qualitative parameters of spermatozoa in terms of the motility, viability, and integrity of DNA. Separated seminal plasma underwent the assessment of the chemical and biochemical composition and RedOx markers. Based on the obtained concentrations of individual chemical elements, the correlation analysis suggested a negative impact of Cu in seminal plasma on the SOD, GPx, and LPO. Contrary, positive correlation was detected between FRAP and motility features. While Cu negatively correlated with sperm motion parameters, the adverse effect on viability was suggested for Cd. Our data suggest that seminal plasma has a potential due to its availability to become the potential biomarker of the reproductive health of farm animals.

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“…Conversely, currently, infertility is one of the main concerns since it affects almost 200 million people worldwide, of which male infertility contributes to 50% [ 25 ]. Spermatogenesis, the proliferative and differentiative progression that leads to SPZ formation, is an extremely intricate and delicate process, which implies different phases and, due to its intrinsic complexity, many mistakes can happen because of exogenous (environmental pollutions) [ 26 , 27 , 28 , 29 , 30 ] and endogenous (genetic defects, anatomic abnormalities) [ 31 ] factors. Among the varying defects that can affect SPZ, influencing their quality, one of the clearer and most evident manifestations of male infertility is globo-theratozoospermia, namely, the presence of SPZ with an abnormal head, often characterized by a defect or total absence of the acrosome [ 7 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis

Venditti

Minucci

2022

Biomedicines

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The identification and characterization of new proteins involved in spermatogenesis is fundamental, considering that good-quality gametes are basic in ensuring proper reproduction. Here, we further analyzed the temporal and spatial localization during the first spermatogenic wave of rat testis of EHBP1L1, which is involved in vesicular trafficking due to the CH and bMERB domains, which bind to actin and Rab8/10, respectively. Western blot and immunofluorescence analyses showed that EHBP1L1 protein expression started at 21 days post-partum (dpp) concomitantly with the appearance of primary spermatocytes (I SPC). In subsequent stages, EHBP1L1 specifically localized together with actin in the perinuclear cytoplasm close to the acrosomal and Golgian regions of spermatids (SPT) during the different phases of acrosome biogenesis (AB). Moreover, it was completely absent in elongated SPT and in mature spermatozoa, suggesting that its role was completed in previous stages. The combined data, also supported by our previous report demonstrating that EHBP1L1 mRNA was expressed by primary (I) and secondary (II) SPC, lead us to hypothesize its specific role during AB. Although these results are suggestive, further studies are needed to better clarify the underlying molecular mechanisms of AB, with the aim to use EHBP1L1 as a potential new marker for spermatogenesis.

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Exogenous Factors Affecting the Functional Integrity of Male Reproduction

Cited by 28 publications

References 175 publications

Consequences of Paternal Nutrition on Offspring Health and Disease

Consequences of Paternal Nutrition on Offspring Health and Disease

Composition of Stallion Seminal Plasma and Its Impact on Oxidative Stress Markers and Spermatozoa Quality

Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis

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