Organophosphate Poisoning and Subsequent Acute Kidney Injury Risk

Lee, Feng-You; Chen, Wei-Kung; Lin, Cheng‐Li; Lai, Chun-Ting; Wu, Yung-Shun; Lin, Iuon-Chang; Kao, Chia‐Hung

doi:10.1097/md.0000000000002107

Cited by 45 publications

(36 citation statements)

References 32 publications

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“…The rapid accumulation of acetylcholine in synaptic junctions of central nervous system and peripheral tissues results in cholinergic crises and this may lead to ischemic ATN[5]. Paraquat (1,1’-dimethyl-4,4’-bipyridylium dichloride) is widely used as a herbicide.…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury from different poisonous substances

Naqvi

2017

WJN

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AIMTo report our experience of acute kidney injury (AKI) developed after exposure to poisonous substance.METHODSRetrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016. This institution is a tertiary care center for renal care in the metropolitan city of Karachi, Pakistan. History of ingested substance, symptoms on presentation, basic laboratory tests on arrival, mode of treatment and outcome were recorded from all patients and are presented here. Patients developing AKI after snake envenomation or scorpion stings are not included in this study.RESULTSDuring studied period 184 cases of AKI developing after poisoning were seen at our institution. The largest group was from paraphenyline diamine poisoning comprising 135 patients, followed by methanol in 8, organophosphorus compounds in 5, paraquat in 5, copper sulphate in 5, tartaric acid in 4, phenobarbitone in 3 and benzodiazipines, datura, rat killer, fish gall bladder, arsenic, boiler water, ammonium dichromate, acetic acid and herbs with lesser frequency. In 8 patients multiple substances were ingested in combination. Renal replacement therapy was required in 96% of patients. Complete recovery was seen in 72.28% patients, 20% died during acute phase of illness.CONCLUSIONIt is important to report poisonous substances causing vital organ failure to increase awareness among general population as well as health care providers.

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Section: Introductionmentioning

confidence: 99%

Acute kidney injury from different poisonous substances

Naqvi

2017

WJN

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“…Lee FY et al, have demonstrated six fold increased risk of AKI in patients with OP poisoning. 13 In this study, 8% and 4% of AKI was associated with malaria and leptospirosis respectively. Increased parasitaemia have led to AKI in falciparum malaria cases.…”

Section: Discussionmentioning

confidence: 94%

Clinical profile and treatment outcome of acute kidney injury (AKI) in a tertiary care hospital

Ananth

Selvaraj

et al. 2018

Int J Adv Med

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Background: Acute Kidney Injury (AKI) is one of the major cause of in-hospital mortality rates globally. The current study was conducted to study the etiological profile, severity and management of acute kidney injury.Methods: The study was a prospective observational study, conducted in the department general medicine, Dhanalakshmi Srinivasan Medical college and Hospital, Permabalur, Tamil Nadu. The study population included all the patients admitted to Intensive Care Unit (ICU) with acute Kidney injury (AKI) between January 2015 to December 2016. All the study participants were recruited to the study by convenient sampling. Descriptive analysis was carried out by frequency and proportion for categorical variables.Results: A total of 100 subjects were included. Participants were almost uniformly distributed in each of a decadal age group till above 60 years. Males (57%) were slightly higher than females (43%). Oliguria was present in 88% of the study population. The most common etiology was acute diarrhoeal disease (44%), followed by multiple infections in 12% and Sepsis in 10% of the subjects. As per RIFLE criteria 46% participants were at risk, 26.0% had injury, 28% had failure. All at risk people were treated conservatively, among injury category, 38.5% were treated by haemodialysis and 3.84% by peritoneal dialysis. In failure group, 60.71% and 3.57% were treated by haemodialysis and peritoneal dialysis respectively.Conclusions: Acute kidney Injury (AKI) can be a consequence of varied aetiologies and all the age groups and both the genders at risk of developing it. RIFLE criteria may be a useful tool in guiding the management.

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“…For cholinergic effects, atropine is used but for nicotinergic effects, oximes are needed in treatment [5]. Kidney injury is an understimated complication of OP poisoning particularly when combined with other intoxications [6]. When kidney injury occurs, hemodyalisis must be kept in mind [7].…”

Section: Organophosphatesmentioning

confidence: 99%

Association of Organophosphate Poisoning with Kidney Injury: A Mini Review

Erenler

Eser

Sarıaydın

et al. 2018

J. Nephrol. Urol. Res.

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Poisoning by Organophosphates is a public health problem particularly in developing countries. Although they are commonly used in agriculture as pesticides, unfortunately, their use as weapons in chemical warfare is not rare. Due to lack of control, they are usually available in stores. Individuals may be effected by these compounds either by accidents or suicidal attempts. Poisoning may ocur following peroral, inhalational or dermal intake. Due to structure of the compound (highly soluble), exposure by each route causes high morbidity and mortality. Organophosphates inhibit both acetylcholinesterase (AChE) and pseudocholinesterase. Inhibition of AChE results in accumulation of acetylcholine. This mechanism is the main reason for toxic effects. Toxic effects may present as muscarinic, nicotinic and central nervous system (CNS). Progression of the poisoning may be seen in three stages: cholinergic phase, intermediate syndrome and delayed neuropathy. Although cardiovascular, gastrointestinal, respiratory, ocular, musculoskeletal and CNS manfestations of the poisoning are well-described in the literature, its effects on renal system remains as a neglected field due to its scarcity. In this mini-review, our aim was to determine hazardous effects of OP poisoning on renal system and emphasize the importance of monitorization and early intervention.

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Organophosphate Poisoning and Subsequent Acute Kidney Injury Risk

Cited by 45 publications

References 32 publications

Acute kidney injury from different poisonous substances

Acute kidney injury from different poisonous substances

Clinical profile and treatment outcome of acute kidney injury (AKI) in a tertiary care hospital

Association of Organophosphate Poisoning with Kidney Injury: A Mini Review

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