Organometallic Compounds and Microorganisms

Thayer, John S.

doi:10.1016/b978-0-12-686080-1.50010-3

Cited by 5 publications

(8 citation statements)

References 56 publications

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“…4 Inorganic Sb(III/V) have been the subject of extensive research for several decades, 5 whereas the investigation of methylated Sb species is of relatively recent interest. 6 The complete understanding of methylated Sb speciation remains elusive. It has been suggested that methylated antimony compounds may demonstrate reduced toxicity relative to their inorganic counterparts.…”

Section: ■ Introductionmentioning

confidence: 99%

Arsenite S-Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120

Li,

Yin,

et al. 2024

Environ. Sci. Technol.

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Antimony (Sb) biomethylation is an important but uninformed process in Sb biogeochemical cycling. Methylated Sb species have been widely detected in the environment, but the gene and enzyme for Sb methylation remain unknown. Here, we found that arsenite S-adenosylmethionine methyltransferase (ArsM) is able to catalyze Sb(III) methylation. The stepwise methylation by ArsM forms mono-, di-, and trimethylated Sb species. Sb(III) is readily coordinated with glutathione, forming the preferred ArsM substrate which is anchored on three conserved cysteines. Overexpressing arsM in Escherichia coli AW3110 conferred resistance to Sb(III) by converting intracellular Sb(III) into gaseous methylated species, serving as a detoxification process. Methylated Sb species were detected in paddy soil cultures, and phylogenetic analysis of ArsM showed its great diversity in ecosystems, suggesting a high metabolic potential for Sb(III) methylation in the environment. This study shows an undiscovered microbial process methylating aqueous Sb(III) into the gaseous phase, mobilizing Sb on a regional and even global scale as a re-emerging contaminant.

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Section: ■ Introductionmentioning

confidence: 99%

Arsenite S-Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120

Li,

Yin,

et al. 2024

Environ. Sci. Technol.

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“…Owing to the well-known toxicity of organotin-(IV) compounds, 1,2 it is very important to check their presence in natural fluids both as regards their total content and their chemical behaviour towards other components of these fluids, by considering suitable chemical speciation models. Several studies 3 have been recently reported in the literature on the analytical methodologies useful for detecting the relative amounts of the different mono-, di-and tri-organotin(IV) derivatives in the aquatic environment, in order to evaluate their fate and transformation, both in water and in sediments.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Alkyltin(IV) Compounds with Ligands of Interest in the Speciation of Natural fluids: Complexes of (CH3)2Sn2+ with Carboxylates

Stefano

Gianguzza

Marrone

et al. 1997

Appl. Organometal. Chem.

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Complex formation by (CH3)2Sn2+ with acetate (ac), malonate (mal), 1,2,3‐propane‐tricarboxylate (tricarballylate, tca) and 1,2,3,4‐butanetetracarboxylate (btc) ligands in aqueous solution is reported. The study has been performed by potentiometry ([H+]–glass electrode) at T=25 °C, and in the 0⩽I⩽1 mol dm−3 ionic strength range. In order to evaluate the salt effects on the formation constants of the complex species, and to contribute to the definition of the chemical speciation of diorganotin(IV) compounds in natural waters where carboxylic ligands are naturally present, interactions of NaCl (which is the major component of all natural fluids), with the components of the systems under investigation have also been considered. A model for the ionic strength dependence of the formation constant was used in order to calculate the values of thermodynamic constants, at infinite dilution, for all the proposed species, by considering hydrolytic species too. A relationship between the charges on the different ligands considered and the stabilities of the complex species formed is also discussed. © 1997 John Wiley & Sons, Ltd.

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“…This underlines the common tendency for compounds of this type; they are normally prescribed as external antibiotics rather than for internal use. In fact most cases of organometallic poisonings are due to ingestion of methylmercury compounds either from marine organisms or from treated seed grain [44].…”

Section: Organometallic Mercury Compoundsmentioning

confidence: 99%

“…This book will not deal in detail with the toxicological and environmental problems associated with the use of organometallics since these subjects have been covered extensively in books by Thayer [44] and Craig [74], respectively. However, it is worth noting that the toxicity of organometallic compounds, e.g.…”

Section: Toxicology and The Environmentmentioning

confidence: 99%

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A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

2005

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Organometallic Compounds and Microorganisms

Cited by 5 publications

References 56 publications

Arsenite S-Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120

Arsenite S-Adenosylmethionine Methyltransferase Is Responsible for Antimony Biomethylation in Nostoc sp. PCC7120

Interaction of Alkyltin(IV) Compounds with Ligands of Interest in the Speciation of Natural fluids: Complexes of (CH3)2Sn2+ with Carboxylates

A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

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