Nowadays green chemistry plays a vital role in organic chemistry. It minimizes the effect and use of hazardous substances on the environment and human health. The main goal of green chemistry is to use of green solvents (PEG, water, acetone, alcohol) eliminate the toxicity, uses of small quantity of catalyst and minimize the potential for chemical accident during work. Green chemistry is one type of chemistry where main focus is to eliminate or minimize the hazards by applying suitable process and raw materials. So it is more effective to pharmacists or chemists for avoiding this bad impact on human health, environment. Green chemistry also known as sustainable chemistry. Green chemistry is always interesting matter to pharmacists as well as chemists for synthesis pharmaceutical products. Green chemistry brings a new path for synthesizing safer chemical products. For manufacturing pharmaceutical products by using green chemistry, there have many criteria or methods that should be followed for synthesis chemical products during manufacturing condition. Some of these are prevention waste, Atom economy, less hazardous chemical syntheses, designing safer chemicals, safer solvents, design for more energy efficient chemical, use of renewable feed stocks, reduce derivatives in any compounds, catalysis, design for degradation, real time analysis for pollution prevention, inherently safer for accident prevention, etc. These methods should be considerable before synthesized chemical products by applying green chemistry for eliminating or minimizing hazardous in chemical products during synthesis.