“…In this context, acrylamides-involved cascade annulation reaction has been explored in great detail, in which acrylamide serves as a N , C β -1,4-synthon to undergo cascade [4 + 2]-annulation reactions with electron-deficient alkenes to construct δ-lactam scaffolds . Comparatively, β-electron-withdrawing group (ester or carbonyl)-tethered acrylamide usually acts as a N , C α -1,3-synthon in chiral amine-catalyzed asymmetric cascade aza-Michael/Michael reaction with α, β-unsaturated aldehydes, as well as Lewis base-catalyzed formal [3 + 2]-annulation reactions with nitro-heteroarenes or isocyanates . On the other hand, cyclic N -sulfonyl imines exhibit versatile reaction activity in organocatalytic, metal-catalyzed, or radical-mediated cycloaddition reactions, which provide straightforward, powerful, and atom-economical methods to a wide range of diverse pharmacologically sultam or sulfamidate-fused nitrogen-containing heterocycles .…”