“…On the other hand, cyclic N -sulfonyl imines exhibit versatile reaction activity in organocatalytic, metal-catalyzed, or radical-mediated cycloaddition reactions, which provide straightforward, powerful, and atom-economical methods to a wide range of diverse pharmacologically sultam or sulfamidate-fused nitrogen-containing heterocycles . Based on our achievements in the field of heterocyclic chemistry involving N -alkoxy α-halohydroxamate or acrylamide, and in line with our continuous efforts in annulation reactions, we have successfully established an Et 3 N-catalyzed aza-Mannich reaction triggered cascade annulation reaction of β-oxo-acrylamides with cyclic N -sulfonyl imines, leading to the formation of highly functionalized sulfamide-fused imidazolidinone derivatives (Scheme f). Meanwhile, we also studied the asymmetric [3 + 2]-cycloaddition reaction using chiral bifunctional squaramide organocatalysts.…”