Lewis base-catalyzed cascade [4 + 2]-annulation reaction of <i>N</i>-alkoxy acrylamides and acyl isothiocyanates: facile access to 2-imino-1,3-thiazinone derivatives

Wang, Zhaoxue; Tian, Ge; Shi, Yuying; Liu, Wanxing; Xu, Xiangdong; Li, Xiaojing; Wu, Lingang; Xie, Lei

doi:10.1039/d3ob01440a

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Aroyl Isothiocyanates1

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2024

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Cited by 4 publications

(1 citation statement)

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“…Metal-free, high atom economy, and scalability are a few salient features of this protocol (Scheme 78). 84…”

Section: Aroyl Isothiocyanatesmentioning

confidence: 99%

Isothiocyanates: happy-go-lucky reagents in organic synthesis

Das,

Dahiya,

Patel

2024

Org. Biomol. Chem.

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“…Metal-free, high atom economy, and scalability are a few salient features of this protocol (Scheme 78). 84…”

Section: Aroyl Isothiocyanatesmentioning

confidence: 99%

Isothiocyanates: happy-go-lucky reagents in organic synthesis

Das,

Dahiya,

Patel

2024

Org. Biomol. Chem.

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Current Developments in Michael Addition Reaction using Heterocycles as Convenient Michael Donors

Samanta,

Shankar Panda,

Mohapatra

et al. 2024

Asian J Org Chem

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The Michael addition reaction, a cornerstone of contemporary organic synthesis, has witnessed a resurgence of interest owing to its ability to forge intricate carbon‐carbon and carbon‐heteroatom bonds. In the past few years, heterocyclic compounds have been rigorously used as Michael donors, owing to their architectural diversity and distinct reactivity with or without the presence of base/transition metals/organocatalysts. This review encapsulates the latest breakthroughs in chemistry involving Michael addition reaction using heterocyclic compounds as Michael donors. It delivers a comprehensive update on developments in Michael addition reaction triggered by potent heterocycles since 2017, highlighting novel and innovative methodologies, with strategic insights.

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Lewis base-catalyzed [3 + 2] annulation of β-oxo-acrylamides with acyl isothiocyanates: facile access to 2-iminothiazolidin-4-one derivatives

Liu,

Mao,

Chong

et al. 2024

Tetrahedron Letters

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Lewis base-catalyzed cascade [4 + 2]-annulation reaction of N-alkoxy acrylamides and acyl isothiocyanates: facile access to 2-imino-1,3-thiazinone derivatives

Abstract: A Lewis base-catalyzed cascade aza-nucleophilic addition/thio-Michael addition reaction of N-alkoxy acrylamides with acyl isothiocyanates has been developed to afford various 2-imino-1,3-thiazinone derivatives in 40–97% yields.

Cited by 4 publications

References 44 publications

Isothiocyanates: happy-go-lucky reagents in organic synthesis

Isothiocyanates: happy-go-lucky reagents in organic synthesis

Current Developments in Michael Addition Reaction using Heterocycles as Convenient Michael Donors

Lewis base-catalyzed [3 + 2] annulation of β-oxo-acrylamides with acyl isothiocyanates: facile access to 2-iminothiazolidin-4-one derivatives

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