“…It is well known that thalidomide exhibits species-specific differences in its teratogenic actions [1,3,8,129]. Many animal organisms have been used to study thalidomide's actions, including chicks, rabbits, zebrafish, marine fish, armadillos, marsupials, hydra, and nonhuman primates [1,2,44,54,121,123,159,[162][163][164][165]. One of the surprising aspects of thalidomide is that rodent embryos are less sensitive to thalidomide with varying results of activity as well as being mouse strain specific [166] and as such customarily are not seen as a primary tool to study thalidomide induced teratogenesis [165,[167][168][169][170][171][172][173][174].…”