2019
DOI: 10.1101/602029
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Abstract: Fat family cadherins are enormous proteins that regulate planar cell polarity (PCP) and cell adhesion in bilaterian animals. Their evolutionary origin can be traced back to prebilaterian species, but their ancestral function(s) are unknown. We identified Fat-like and Dachsous cadherins in Hydra, a member of the earlydiverging metazoan phylum Cnidaria. Hydra has a simple body plan with only two epithelial layers and radial symmetry. We find that Hydra homologues of Fat-like (HyFat) and Dachsous (HyDs) co-locali… Show more

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Cited by 1 publication
(2 citation statements)
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“…Planar cell polarity genes fat and fat -like genes are associated with cell directional migration and morphogenesis in asymmetric cell division in bilaterians ( Matis and Axelrod 2013 ). The Hydra fat and dachsous genes localise to the body of the animals where continuous growth and migration of cells occur supporting the theory of a similar role to that of bilaterians ( Brooun et al, 2019 ). Phylogenetic examination of frizzled in a variety of different poriferan, placozoan, cnidarian and ctenophore species show multiple orthologues of frizzled.…”
Section: Transitioning To Multicellularity: the First Animalssupporting
confidence: 55%
See 1 more Smart Citation
“…Planar cell polarity genes fat and fat -like genes are associated with cell directional migration and morphogenesis in asymmetric cell division in bilaterians ( Matis and Axelrod 2013 ). The Hydra fat and dachsous genes localise to the body of the animals where continuous growth and migration of cells occur supporting the theory of a similar role to that of bilaterians ( Brooun et al, 2019 ). Phylogenetic examination of frizzled in a variety of different poriferan, placozoan, cnidarian and ctenophore species show multiple orthologues of frizzled.…”
Section: Transitioning To Multicellularity: the First Animalssupporting
confidence: 55%
“…The Hydra fat and dachsous genes localise to the body of the animals where continuous growth and migration of cells occur supporting the theory of a similar role to that of bilaterians (Brooun et al, 2019). Phylogenetic examination of frizzled in a variety of different poriferan, placozoan, cnidarian and ctenophore species show multiple orthologues of frizzled.…”
Section: Planar Cell Polarity Signallingmentioning
confidence: 59%