Organized Pneumonia Secondary to Increasing Doses of Temozolomide

Abstract

Surgery, radiotherapy (RT), and chemotherapy have a role in the control of tumor growth, progression, and recurrence in high-grade gliomas. Temozolomide has been incorporated as the main chemotherapy agent for managing these tumors. Here, we present a case of a patient who developed a severe organizing pneumonia after increasing doses of temozolomide for a high-grade glioma.

Temozolomide-Associated Organizing Pneumonia

“…There are only 6 reported cases of organizing pneumonia secondary to temozolomide (Table 1). [6][7][8][9][10][11] The mean age of the patients was 61.8 years, ranging from 50 to 88 years of age. Four patients were females and 2 were males.…”