Temozolomide-Associated Organizing Pneumonia

Abdullah, Hafez Mohammad Ammar; Gowda, Smitha Narayana; Sharma, Rakshya; Ellithi, Moataz; Oberoi, Mansi

doi:10.1097/mjt.0000000000001162

Cited by 2 publications

(1 citation statement)

References 12 publications

(13 reference statements)

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“…Organizing Pneumonia (OP) is currently recognized as a nonspecific lung injury pattern that has already been widely described under various names in the past [81][82][83][84]. OP can be secondary (Secondary Organizing Pneumonia, SOP), representing the histopathological manifestation of many clinical conditions such as CTD-ILD, drug reaction, HP, pulmonary infections and aspiration [85][86][87][88][89][90][91][92][93][94][95][96][97][98][99], or it may be not associated with a known cause or clinical condition, and appears to be idiopathic (Cryptogenic Organizing Pneumonia, COP) [27,100,101]. The histopathological hallmark of OP pattern is a patchy airspace filled by plugs of plump fibroblasts-myofibroblasts combined with variable numbers of admixed chronic inflammatory cells and embedded in a pale staining myxoid matrix of immature loose connective tissue with a polypoid shape, known as Masson bodies [22,101,102].…”

Section: Cryptogenic Organizing Pneumonia-organizing Pneumoniamentioning

confidence: 99%

Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role

Lucà,

Pagliuca,

Perrotta

et al. 2024

IJMS

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Idiopathic Interstitial Pneumonias (IIPs) are a heterogeneous group of the broader category of Interstitial Lung Diseases (ILDs), pathologically characterized by the distortion of lung parenchyma by interstitial inflammation and/or fibrosis. The American Thoracic Society (ATS)/European Respiratory Society (ERS) international multidisciplinary consensus classification of the IIPs was published in 2002 and then updated in 2013, with the authors emphasizing the need for a multidisciplinary approach to the diagnosis of IIPs. The histological evaluation of IIPs is challenging, and different types of IIPs are classically associated with specific histopathological patterns. However, morphological overlaps can be observed, and the same histopathological features can be seen in totally different clinical settings. Therefore, the pathologist’s aim is to recognize the pathologic–morphologic pattern of disease in this clinical setting, and only after multi-disciplinary evaluation, if there is concordance between clinical and radiological findings, a definitive diagnosis of specific IIP can be established, allowing the optimal clinical–therapeutic management of the patient.

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