Organization of visual mossy fiber projections and zebrin expression in the pigeon vestibulocerebellum

Pakan, Janelle M.P.; Wylie, Douglas R.

doi:10.1002/cne.22192

Cited by 42 publications

(56 citation statements)

References 134 publications

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“…Although the present study and that of Pakan et al (2011) found that CSA of PCs within a given optic flow zone was identical in both the ZIIϩ and ZIIϪ stripe, recent evidence suggests that ZIIϩ and ZIIϪ stripes are functionally different. For example, Pakan et al (2010) showed that MF inputs from two retinorecipient nuclei in pigeons that are responsive to optic flow, the pretectal nucleus lentiformis mesencephali (LM) and the nucleus of the basal optic root (nBOR), project preferentially to ZIIϩ stripes in IXcd. Whether there are MF afferents that project preferentially to ZIIϪ PCs in the pigeon remains to be seen.…”

Section: Discussionmentioning

confidence: 99%

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Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Graham

Wylie

2012

J. Neurosci.

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The cerebellum is a site of complex sensorimotor integration and contains up to 80% of the neurons in the brain, yet comparatively little is known about the organization of sensorimotor systems within the cerebellum. It is known that afferent projections and Purkinje cell (PC) response properties are organized into sagittal "zones" in the cerebellum. Moreover, the isoenzyme aldolase C [also known as zebrin II (ZII)] is heterogeneously expressed in cerebellar PCs such that there are sagittal stripes of PCs with high expression (ZIIϩ) interdigitated with stripes of little or no expression (ZIIϪ). In the present study, we show how the ZII stripes in folium IXcd of the vestibulocerebellum in pigeons are related to response properties of PCs. IXcd consists of seven pairs of ZIIϩ/Ϫ stripes denoted P1ϩ/Ϫ (medial) to P7ϩ/Ϫ (lateral). Electrophysiological studies have shown that vestibulocerebellar PCs respond to particular patterns of optic flow resulting from self-motion in three-dimensional space. In our study, we recorded optic flow preferences from PCs in IXcd, marked recording locations with injections of fluorescent tracer, and subsequently immunoreacted coronal sections for ZII. We found that the PCs within a ZIIϩ/Ϫ stripe pair all responded best to the same pattern of optic flow. That is, a ZIIϩ/Ϫ stripe pair forms a functional unit in the cerebellum. This is the first demonstration that the function of PCs is associated with ZII stripes across the mediolateral extent of an entire folium.

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Section: Discussionmentioning

confidence: 99%

“…1 B, 5A, B). P2ϩ is consistently wide throughout the rostrocaudal extent of IXcd and is separated into medial (P2ϩmed) and lateral (P2ϩlat) portions by a small "notch" ϳ50 m wide in the middle that appeared to contain no PCs (Pakan et al, 2010) (Figs. 1 B, 5 A, B, inverted triangle).…”

Section: Zii Immunohistochemistry Of Folium Ixcdmentioning

confidence: 99%

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Graham

Wylie

2012

J. Neurosci.

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“…4 ) that divides the P2+ stripe into medial and lateral halves were present in both tinamous and pigeons. In pigeons, the ZII stripes within the VbC correspond to specific patterns of optic flow, such that each optic flow sagittal zone encompasses an adjacent ZII+/-stripe pair [Graham and Wylie, 2012;Pakan et al, 2010Wylie, 2013]. The VbC is a site for the integration of vestibular [Wilson et al, 1974], optic flow [Wylie andFrost, 1991, 1993;, and cutaneous information [Schulte and Necker, 1998] and it is critical for mediating compensatory head, body, and eye movements to facilitate retinal image stabilization [Waespe and Henn, 1987].…”

Section: Discussionmentioning

confidence: 99%

Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou <b><i>(Nothoprocta perdicaria)</i></b>

Corfield

Kolominsky²,

Marı́n³

et al. 2015

Brain Behav Evol

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Zebrin II (ZII) is a glycolytic enzyme expressed in cerebellar Purkinje cells. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with a high ZII expression (ZII+) alternating with stripes of Purkinje cells with little or no expression (ZII-). To date, ZII expression studies are limited to neognathous birds: pigeons (Columbiformes), chickens (Galliformes), and hummingbirds (Trochilidae). These previous studies divided the avian cerebellum into 5 transverse regions based on the pattern of ZII expression. In the lingular region (lobule I) all Purkinje cells are ZII+. In the anterior region (lobules II-V) there are 4 pairs of ZII+/- stripes. In the central region (lobules VI-VIII) all Purkinje cells are ZII+. In the posterior region (lobules VIII-IX) there are 5-7 pairs of ZII+/- stripes. Finally, in the nodular region (lobule X) all Purkinje cells are ZII+. As the pattern of ZII stripes is quite similar in these disparate species, it appears that it is highly conserved. However, it has yet to be studied in paleognathous birds, which split from the neognaths over 100 million years ago. To better understand the evolution of cerebellar compartmentation in birds, we examined ZII immunoreactivity in a paleognath, the Chilean tinamou (Nothoprocta perdicaria). In the tinamou, Purkinje cells expressed ZII heterogeneously such that there were sagittal ZII+ and ZII- stripes of Purkinje cells, and this pattern of expression was largely similar to that observed in neognathous birds. For example, all Purkinje cells in the lingular (lobule I) and nodular (lobule X) regions were ZII+, and there were 4 pairs of ZII+/- stripes in the anterior region (lobules II-V). In contrast to neognaths, however, ZII was expressed in lobules VI-VII as a series of sagittal stripes in the tinamou. Also unlike in neognaths, stripes were absent in lobule IXab, and all Purkinje cells expressed ZII in the tinamou. The differences in ZII expression between the tinamou and neognaths could reflect behavior, but the general similarity of the expression patterns across all bird species suggests that ZII stripes evolved early in the avian phylogenetic tree.

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“…The zonal organization of the cerebellar cortex is a highly conserved feature throughout vertebrates [Voogd, 2003]. SC fiber terminal fields also show parasagittal bands in the granular layer, of which the boundary is ill-defined in comparison to climbing fiber terminal fields or antigenic parasagital bands such as zebrin II [Tolbert et al, 1993;Wu et al, 1999;Voogd et al, 2003;Pakan et al, 2010]. It is pivotal for elucidation of cerebellar function to determine whether parasagittal bands of SC fiber terminals have a close correlation to the Purkinje cell compartment.…”

Section: Introductionmentioning

confidence: 99%

“…It is pivotal for elucidation of cerebellar function to determine whether parasagittal bands of SC fiber terminals have a close correlation to the Purkinje cell compartment. An investigation of spatial relationships of mossy fiber terminal fields to zebrin expression of Purkinje cells or climbing fiber terminal fields has progressed gradually [Matsu shita et al, 1991;Hawkes, 1994, 1996;Gravel and Hawkes, 1990;Voogd et al, 2003;Pijpers et al, 2006;Pakan et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Furue

Uchida²,

Shinozaki³

et al. 2010

Brain Behav Evol

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In birds, spinocerebellar (SC) projections to the cerebellar cortex have not been understood well. We examined SC fiber terminal fields originating from the cervical and lumbosacral enlargements (CE and LSE, respectively) in the chicken. SC fiber terminals show parasagittal bands in the granular layer. Labeled terminals from the CE were distributed primarily in folia II–V and IX. Parasagittal bands of labeled terminals from the CE were not clearly separated in folia II and III but were clearly separated in folia IV and V. In folium IX, labeled terminals were diffusely distributed in all subfolia with no evidence of banding. The numbers of bands were 5 in folium II, 12 in folium III and 7 in folia IV and V at maximum. Labeled terminals from the LSE were distributed primarily in folia II–VI and IX. Labeled terminals from the LSE were arranged in 4 bands in folium II and in 8 bands in folium III at maximum. Parasagittal bands from the LSE in folia IV and V were not clearly separated. In folium VI, the numbers of parasagittal bands was 6 at maximum. In folium IX, labeled terminals were mainly found in subfolium IXc forming 6–8 parasagittal bands. There were more parasagittal bands of labeled terminals from the CE than from the LSE. The topography of SC fiber terminals from the CE was different from that of SC fiber terminals from the LSE.

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Organization of visual mossy fiber projections and zebrin expression in the pigeon vestibulocerebellum

Cited by 42 publications

References 134 publications

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou <b><i>(Nothoprocta perdicaria)</i></b>

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

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