Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou &lt;b&gt;&lt;i&gt;(Nothoprocta perdicaria)&lt;/i&gt;&lt;/b&gt;

Corfield, Jeremy R.; Kolominsky, Jeffery; Marı́n, Gonzalo; Craciun, Iulia; Mulvany-Robbins, Bridget E.; Iwaniuk, Andrew N.; Wylie, Douglas R.

doi:10.1159/000380810

Cited by 16 publications

(22 citation statements)

References 67 publications

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“…In the kiwi cerebellum, ZII expression showed a pattern consistent with that described in other birds Iwaniuk et al, 2009b;Marzban et al, 2010;Corfield et al, 2015], with sagittally oriented stripes that alternated between high (ZII+) and low (ZII-) immunoreactivity ( fig. 5 a).…”

Section: Zii Expression In the Kiwi Cerebellumsupporting

confidence: 77%

“…A positive ZII stripe was defined as having intense Purkinje cell labeling and a negative ZII stripe as having little to no labeling. Similar to the pigeon and the Chilean tinamou Corfield, et al, 2015], a third labeling intensity was present in a minority of Purkinje cells where the ZII labeling was clearly positive, more so than a negative ZII stripe, but the expression level was clearly less intense than in the adjacent ZII+ cells. To remove observer bias, subsets of sections were also measured by a second observer; no appreciable differences were noted.…”

Section: Zii Stripe Reconstructionsmentioning

confidence: 71%

“…For this, images of coronal sections were loaded in to Amira and aligned based on anatomical features of the cerebellar folia. In Amira there is an option to then resample the images so that they can be viewed on either the sagittal or the axial plane [Corfield et al, 2015]. The virtual midsagittal section was then compared to actual midsagittal sections from those brains sectioned on the sagittal plane.…”

Section: Folium Classification and Measurementsmentioning

confidence: 99%

“…To remove observer bias, subsets of sections were also measured by a second observer; no appreciable differences were noted. The stripes are numbered following the nomenclature used in other bird species, with the most medial positive stripe being designated P1+, or simply 1, and the number increases as the stripes move laterally to 7 Iwaniuk et al, 2009b;Marzban et al, 2010;Corfield et al 2015]. The expression patterns were plotted using graphing software (SigmaPlot v11; Systat Software, Inc.) and shading and labels were added using Coreldraw X5 (Corel Corporation).…”

Section: Zii Stripe Reconstructionsmentioning

confidence: 99%

“…Bird species that use tools and build complex nests, for example, have a more foliated cerebellar cortex [Iwaniuk et al, 2009a;Hall et al, 2013], and those that are strong fliers, like ducks and seabirds, have larger folia VI and VII and smaller folia I-III . In hummingbirds (Calypte anna and Selasphorus rufus) and related caprimulgiforms, poor hindlimb musculature has likely resulted in an extreme reduction of the anterior lobe (folia I-V) [Iwaniuk et al, 2006[Iwaniuk et al, , 2009b, whereas in birds that rely on strong leg musculature, the anterior lobe tends to be larger Corfield et al, 2015].…”

Section: Introductionmentioning

confidence: 99%

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Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi (Apteryx mantelli)?

Corfield

Kolominsky²,

Craciun³

et al. 2016

Brain Behav Evol

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Among some mammals and birds, the cerebellar architecture appears to be adapted to the animal's ecological niche, particularly their sensory ecology and behavior. This relationship is, however, not well understood. To explore this, we examined the expression of zebrin II (ZII) in the cerebellum of the kiwi (Apteryx mantelli), a fully nocturnal bird with auditory, tactile, and olfactory specializations and a reduced visual system. We predicted that the cerebellar architecture, particularly those regions receiving visual inputs and those that receive trigeminal afferents from their beak, would be modified in accordance with their unique way of life. The general stripe-and-transverse region architecture characteristic of birds is present in kiwi, with some differences. Folium IXcd was characterized by large ZII-positive stripes and all Purkinje cells in the flocculus were ZII positive, features that resemble those of small mammals and suggest a visual ecology unlike that of other birds. The central region in kiwi appeared reduced or modified, with folium IV containing ZII+/- stripes, unlike that of most birds, but similar to that of Chilean tinamous. It is possible that a reduced visual system has contributed to a small central region, although increased trigeminal input and flightlessness have undoubtedly played a role in shaping its architecture. Overall, like in mammals, the cerebellar architecture in kiwi and other birds may be substantially modified to serve a particular ecological niche, although we still require a larger comparative data set to fully understand this relationship.

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Section: Zii Expression In the Kiwi Cerebellumsupporting

confidence: 77%

Section: Zii Stripe Reconstructionsmentioning

confidence: 71%

Section: Folium Classification and Measurementsmentioning

confidence: 99%

Section: Zii Stripe Reconstructionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi (Apteryx mantelli)?

Corfield

Kolominsky²,

Craciun³

et al. 2016

Brain Behav Evol

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The centrifugal visual system of a palaeognathous bird, the Chilean Tinamou (Nothoprocta perdicaria)

Krabichler

Vega‐Zuniga

Carrasco

et al. 2017

J of Comparative Neurology

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The avian centrifugal visual system, which projects from the brain to the retina, has been intensively studied in several Neognathous birds that have a distinct isthmo-optic nucleus (ION). However, birds of the order Palaeognathae seem to lack a proper ION in histologically stained brain sections. We had previously reported in the palaeognathous Chilean Tinamou (Nothoprocta perdicaria) that intraocular injections of Cholera Toxin B subunit retrogradely label a considerable number of neurons, which form a diffuse isthmo-optic complex (IOC). In order to better understand how this IOC-based centrifugal visual system is organized, we have studied its major components by means of in vivo and in vitro tracing experiments. Our results show that the IOC, though structurally less organized than an ION, possesses a dense core region consisting of multipolar neurons. It receives afferents from neurons in L10a of the optic tectum, which are distributed with a wider interneuronal spacing than in Neognathae. The tecto-IOC terminals are delicate and divergent, unlike the prominent convergent tecto-ION terminals in Neognathae. The centrifugal IOC terminals in the retina are exclusively divergent, resembling the terminals from "ectopic" centrifugal neurons in Neognathae. We conclude that the Tinamou's IOC participates in a comparable general IOC-retina-TeO-IOC circuitry as the neognathous ION. However, the connections between the components are structurally different and their divergent character suggests a lower spatial resolution. Our findings call for further comparative studies in a broad range of species for advancing our understanding of the evolution, plasticity and functional roles of the avian centrifugal visual system.

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Inferior olivary projection to the zebrin II stripes in lobule IXcd of the pigeon flocculus: A retrograde tracing study

Wylie

Gutiérrez-Ibáñez

Corfield

et al. 2017

J of Comparative Neurology

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Zebrin II (ZII; a.k.a. aldolase C) is expressed heterogeneously in Purkinje cells (PCs) such that there are sagittal stripes of high expression (ZII+) interdigitated with stripes of little or no expression (ZII-). The pigeon flocculus receives visual-optokinetic information and is important for generating compensatory eye movements. It consists of 4 sagittal zones based on PC complex spike activity (CSA) in response to rotational optokinetic stimuli. There are two zones where CSA responds best to rotation about the vertical axis (VA), interdigitated with two zones where CSA responds best to rotation about an horizontal axis (HA). These optokinetic zones relate to the ZII stripes in folium IXcd of the flocculus, such that an optokinetic zone spans a ZII+/- pair: the HA zones span the P5+/- and P7+/- ZII stripe pairs, whereas the VA zones correspond to ZII stripe pairs P4+/- and P6+/-. In the present study, we used fluorescent retrograde tracing to determine the olivary inputs to the ZII+ and ZII- stripes within the functional pairs. We found that separate but adjacent areas of the medial column of the inferior olive (mcIO) project to the ZII+ and ZII- stripes within each of the functional pairs. Thus, although a ZII+/- stripe pair represents a functional unit in the pigeon flocculus insofar as the CSA of all PCs in the stripe pair encodes similar sensory information, the olivary inputs to the ZII+ and ZII- stripes arise from different, although adjacent, regions of the mcIO.

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Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou <b><i>(Nothoprocta perdicaria)</i></b>

Cited by 16 publications

References 67 publications

Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi <b><i>(Apteryx mantelli)</i></b><b>?</b>

Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi <b><i>(Apteryx mantelli)</i></b><b>?</b>

The centrifugal visual system of a palaeognathous bird, the Chilean Tinamou (Nothoprocta perdicaria)

Inferior olivary projection to the zebrin II stripes in lobule IXcd of the pigeon flocculus: A retrograde tracing study

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