Organization of the Medullary Circulation: Functional Implications

Bankir, Lise; Bouby, Nadine; Trinh–Trang–Tan, Marie–Marcelle

doi:10.1007/978-1-4612-5284-9_10

Cited by 7 publications

(10 citation statements)

References 53 publications

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“…In many rodent species thin limbs of short-looped nephrons deviate toward (rat) or become incorporated within (psammomys) the bundles (2, 5-7), while collecting ducts, thick ascending limbs and the thin descending limbs oflong-looped nephrons remain in the interbundle region. As pointed out by Lemley and Kriz (6), Bankir et al (2), and others (5, 7), blood that perfuses nephrons in each region of the kidney returns to the cortex without the opportunity to exchange solutes and water with blood supplying the other region. It is important therefore to determine the permeability properties of vessels and tubules in each region.…”

Section: Discussionmentioning

confidence: 97%

“…All DVR arise from efferent arterioles of juxtamedullary glomeruli and reach their destinations by first passing through outer medullary vascular bundles. DVR on the periphery of the bundles give rise to the rich capillary plexus that invests the outer medullary interbundle region of the inner stripe (2,5), DVR in the center of the bundles continue to the inner medulla before terminating in capillaries.…”

Section: Discussionmentioning

confidence: 99%

“…Perhaps the most striking feature of the medullary microcirculation in water conserving species is the incorporation of descending (DVR)' and ascending (AVR) vasa recta into tightly packed vascular bundles in the inner stripe of the outer medulla (2)(3)(4)(5). Efferent arterioles arising from juxtamedullary glomeruli give rise to DVR, all of which reach their destinations by way of vascular bundles.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, AVR from the plexus in the outer medullary interbundle region reach the cortex without joining the vascular bundles (6). In many species, descending thin limbs of short looped nephrons migrate to the periphery of the bundles or become incorporated within the bundle region (2)(3)(4)(5)(6). Taken together it seems apparent that the anatomical arrangement serves a vital role(s) in the renal medullary handling of solutes and water.…”

Section: Introductionmentioning

confidence: 99%

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Transport of sodium and urea in outer medullary descending vasa recta.

Pallone¹,

Work²,

Myers³

et al. 1994

J. Clin. Invest.

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We dissected and perfused outer medullary vasa recta (OMVR) from vascular bundles in the rat. Permeabilities of sodium (PNa) and urea (P.) were simultaneously determined from the lumen-to-bath efflux of 22Na and [ '4C Iurea. PNa and P.were also measured by in vivo microperfusion of descending (DVR) and ascending vasa recta (AVR) at the papillary tip of Munich-Wistar rats. In some OMVR PN. was indistinguishable from zero. The mean±SE of PNa(X10-, cm/s) in OMVR was 76±9. P. in OMVR was always very high (X10-5, cm/s), 360±14. There was no correlation between OMVR PN. and P,. Inner medullary AVR and DVR had PN. of 115±10 and 75±10, respectively, and P. of 121±10 and 76±11, respectively. PN. and P, in papillary vasa recta were always nearly identical and highly correlated. Transport of ["4C] urea in OMVR was reversibly inhibited by addition of unlabeled urea or phloretin to the bath and lumen, providing evidence for carrier-mediated transport. These data suggest that sodium and urea might traverse the wall of inner medullary vasa recta by a paracellular pathway while urea also crosses by a transcellular route in OMVR. Electron microscopic examination of seven in vitro perfused OMVR revealed no fenestrations and exposure of these vessels to 10 ,M calcium ionophore A23187 or 1 nM angiotensin II resulted in reversible contraction, suggesting that in vitro perfused OMVR are DVR only. (J. Clin. Invest. 1994. 93:212-222.)

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transport of sodium and urea in outer medullary descending vasa recta.

Pallone¹,

Work²,

Myers³

et al. 1994

J. Clin. Invest.

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“…Three types of nephron have been distinguished: superficial, midcortical and juxtamedullary; each of them is composed of a proximal tubule, a short or long loop of Henle and a distal tubule. By using microscopic and microdissection techniques, each nephron segment has been carefuly identified and is easily recognized by anatomical and morphological criteria (Kriz, 1981;Kriz & Bankir, 1988 Bouby & Trinh-Trang-Tan, 1987;Tisher & Madsen, 1995 whether GCs are concentrated specifically in one of the renal zones (e.g. the inner medulla and papilla) as reported for urea and organic osmolytes (Wirthensohn, Beck & Guder, 1987;Yancey & Burg, 1989;Guder, Beck & Schmolke, 1990;Schmolke, Bornemann & Guder, 1990 Pieces of tissue were sampled from C, OS and IS whereas the whole of the rat inner medulla was used.…”

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confidence: 99%

Renal handling of guanidino compounds in rat and rabbit.

Levillain

Marescau

Deyn

1997

The Journal of Physiology

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1. Guanidino compounds (GCs) have been quantified in different mammalian tissues such as brain, liver, muscle and kidney. The high anatomical heterogeneity of the kidney suggests that GCs could be unevenly distributed along the corticopapillary axis of the kidney in different species. 2. This study was designed to quantify twelve GCs in the different zones of rat and rabbit kidney. The kidneys were sliced and pieces of seven definite zones were weighed and homogenized for further GC extraction. GCs were determined by liquid chromatography. 3. The results indicate that: (1) GCs were unevenly distributed along rat and rabbit kidney; (2) qualitative and quantitative studies proved that each GC shows a particular distribution pattern along the corticopapillary axis for a given species; (3) in rats, alpha‐keto‐delta‐guanidinovaleric acid, guanidinosuccinic acid, creatinine (CTN), methylguanidine and to a lesser extent gamma‐guanidinobutyric acid increased steeply along the inner medulla in parallel to urea, whereas in rabbits, most of the GCs reached a plateau in the inner medulla and remained constant at this level; (4) gamma‐guanidinobutyric acid was specifically found in the rat kidney; (5) argininic acid was higher in rabbit compared with rat kidney; (6) significantly higher levels of homoarginine were found in all zones of the rat kidney compared with the rabbit kidney. 4. The results suggest that: (1) GCs are mostly localized within the nephron segments; (2) an accumulation of GCs in the inner medulla might be explained either by a recycling process or by an intracellular storage as has been reported for urea, amino acids and organic osmolytes; (3) some GCs might be synthesized in nephron segments as reported for arginine (Arg) and guanidinoacetic acid (GAA); (4) several metabolic pathways of the GCs seemed to differ between rat and rabbit; (5) except for creatine, CTN, Arg and GAA, it seems unlikely that GCs might significantly increase the intracellular osmolality.

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Morphology of the Loop of Henle, Distal Tubule, and Collecting Duct

Kaissling

Kriz

1992

Comprehensive Physiology

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The sections in this article are: Loops of Henle Intermediate Tubule Thick Ascending Limb Macula Densa Distal Segments Definition and Nomenclature General Cytological Organization of the Distal Segments Distal Convoluted Tubule Connecting Tubule Cortical Collecting Duct Medullary Collecting Ducts Microanatomical Organization and Histotopographical Aspects Outer Medullary Collecting Duct Inner Medullary Collecting Duct Cytochemical Aspects Structure—Function Correlations Intercalated Cells Cell Structure Intercalated Cells in the Cortex Cytochemical Aspects Distribution of Intercalated Cells in the Kidney Zones Structure—Function Correlations

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Organization of the Medullary Circulation: Functional Implications

Cited by 7 publications

References 53 publications

Transport of sodium and urea in outer medullary descending vasa recta.

Transport of sodium and urea in outer medullary descending vasa recta.

Renal handling of guanidino compounds in rat and rabbit.

Morphology of the Loop of Henle, Distal Tubule, and Collecting Duct

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