Organization of histaminergic fibers in the rat brain

Inagaki, Naoyuki; Yamatodani, Atsushi; Ando-Yamamoto, Maya; Tohyama, Masaya; Watanabe, Takehiko; Wada, Hiroshi

doi:10.1002/cne.902730302

Cited by 360 publications

(180 citation statements)

References 46 publications

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“…They may also thus affect cortical cholinergic activity by acting at postsynaptic H 3 receptors localized on GABAergic neurons. dominantly ipsilaterally and with multifold arborizations, into the whole central nervous system, including the NBM, MSA-DB, amygdala, hippocampus and cerebral cortex [64,96,123,130]. Fig.…”

Section: Modulation Of Hippocampal Cholinergic Tone By Histaminementioning

confidence: 98%

Interactions between histaminergic and cholinergic systems in learning and memory

Bacciottini

Passani

Mannaioni

et al. 2001

Behavioural Brain Research

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The aim of this review is to survey biochemical, electrophysiological and behavioral evidence of the interactions between the cholinergic and histaminergic systems and evaluate their possible involvement in cognitive processes. The cholinergic system has long been implicated in cognition, and there is a plethora of data showing that cholinergic deficits parallel cognitive impairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans. Several other neurotransmitters, though, are clearly implicated in cognitive processes and interact with the cholinergic system. The neuromodulatory effect that histamine exerts on acetylcholine release is complex and multifarious. There is clear evidence indicating that histamine controls the release of central acetylcholine (ACh) locally in the cortex and amygdala, and activating cholinergic neurones in the nucleus basalis magnocellularis (NBM) and the medial septal area-diagonal band that project to the cortex and to the hippocampus, respectively. Extensive experimental evidence supports the involvement of histamine in learning and memory and the procognitive effects of H 3 receptor antagonists. However, any attempt to strictly correlate cholinergic/histaminergic interactions with behavioral outcomes without taking into account the contribution of other neurotransmitter systems is illegitimate. Our understanding of the role of histamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function.

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Section: Modulation Of Hippocampal Cholinergic Tone By Histaminementioning

confidence: 98%

Interactions between histaminergic and cholinergic systems in learning and memory

Bacciottini

Passani

Mannaioni

et al. 2001

Behavioural Brain Research

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“…Therefore activation of CRH-, AVP-and OT-containing neurons may be essential for the HA-induced release of pituitary hormones. In accordance with this hypothesis, hypothalamic nuclei, including the paraventricular nucleus (PVN) and the supraoptic nucleus (SON), which contain CRH, AVP and OT neurons (10), are innervated by histaminergic fibers (11,12), which thereby provide the anatomical basis for a functional interrelation between histaminergic neurons and CRH, AVP and OT neurons. Furthermore, we have recently found that centrally administered HA stimulates the expression of c-fos in hypothalamic CRH, AVP and OT neurons (13) and the formation of CRH, AVP and OT mRNA in the hypothalamus (14), suggesting that these neurons are activated by HA.…”

Section: Introductionmentioning

confidence: 94%

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

Kjær¹,

Larsen

Knigge³

et al. 1998

European Journal of Endocrinology

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Centrally administered histamine (HA) stimulates the secretion of the pro-opiomelanocortin-derived peptides ACTH and b-endorphin as well as prolactin. The effect of HA on secretion of these adenohypophysial hormones is indirect and may involve activation of hypothalamic neurons containing corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) or oxytocin (OT).We studied the effect of activating central HA receptors by central infusion of HA, HA agonists or antagonists on expression of CRH, AVP and OT mRNA in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei.Intracerebroventricular infusion of HA (270 nmol), the H 1 -receptor agonist 2-thiazolylethylamine or the H 2 -receptor agonist 4-methylhistamine increased the level of CRH mRNA in the PVN, and OT mRNA in the SON. In contrast, none of these compounds had any effect on expression of AVP mRNA in the PVN or SON. Administration of the H 1 -receptor antagonist mepyramine or the H 2 -receptor antagonist cimetidine had no effect on basal expression of CRH, AVP or OT mRNA in the PVN and/or SON except for a slight inhibitory effect of cimetidine on CRH mRNA expression in the PVN. Pretreatment with mepyramine or cimetidine before HA administration inhibited the HA-induced increase in OT mRNA levels but had no effect on the HA-induced increase in CRH mRNA levels in the PVN.We conclude that HA stimulates hypothalamic CRH and OT neurons by increasing mRNA levels, and this effect seems to be mediated via activation of both HA H 1 and H 2 receptors.

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“…Histamine is also released by activation of heteroreceptors (Hill and Straw, 1988;Gulat-Marnay et al, 1989a, 1990Prast et al, 1991;Ono et al, 1992;Chikai et al, 1994;Laitinen et al, 1995). Histaminergic neurons are concentrated in the tuberomammillary nucleus of the posterior basal hypothalamus (Panula et al, 1984;Watanabe et al, 1984) and project to various brain regions (Inagaki et al, 1988;Panula et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

Bongers

Leurs

Robertson

et al. 2003

Neuropsychopharmacol

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Increasing evidence supports a role for histamine as a neurotransmitter and neuromodulator in emotion and cognition. The H 3 receptor was first characterized as an autoreceptor that modulates histamine release and synthesis via negative feedback. Mice deficient in apoE (Apoe -/-) have been used to define the role of apoE in brain function. In the present study, we investigated the possible role of histamine H 3 -receptor-mediated signaling in anxiety and cognition in mice Apoe -/-and wild-type mice. H 3 antagonists increased measures of anxiety in wild-type, but not Apoe -/-, mice. In contrast, H 3 antagonists similarly impaired object recognition in wild-type and Apoe -/-mice. In Apoe -/-mice, reduced negative feedback via H 3 receptors could contribute to increased signaling of H 1 receptors. Apoe -/-mice showed higher sensitivity to the anxiety-reducing effects of the H 1 receptor antagonist mepyramine than wild-type mice. These effects were dissociated from effects of mepyramine on the HPA axis. Compared to saline controls, mepyramine reduced plasma ACTH and corticosterone levels in wild-type, but not Apoe -/-, mice. These data support a role for apoE in H 3 receptor signaling. H 3 antagonists were proposed as a treatment for cognitive disorders such as Alzheimer's disease, which is associated with increased anxiety and cognitive impairments. As H 3 antagonists increase measures of anxiety and impair object recognition in wild-type mice, the use of H 3 antagonists in cognitive disorders may be counterproductive and should be carefully evaluated.

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Organization of histaminergic fibers in the rat brain

Cited by 360 publications

References 46 publications

Interactions between histaminergic and cholinergic systems in learning and memory

Interactions between histaminergic and cholinergic systems in learning and memory

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

Role of H3-Receptor-Mediated Signaling in Anxiety and Cognition in Wild-Type and Apoe–/– Mice

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