Organic Surface Modification of Silicon Nanowire-Based Sensor Devices

Investigation into the Effect of Varied Functional Biointerfaces on Silicon Nanowire MOSFETs

“…In addition, the surface modification or functionalization introduces functional groups and then creates an interface between the biological system and the electronic device for detection of neuronal signals [15] and observation of cell growth [16]. Organosilane molecules are popular candidates for reacting with hydroxyl-terminated surfaces [17]. When cleaned silicon substrates are exposed to an ambient environment, silicon oxide layer spontaneously grow on the outermost substrates [17].…”

“…Organosilane molecules are popular candidates for reacting with hydroxyl-terminated surfaces [17]. When cleaned silicon substrates are exposed to an ambient environment, silicon oxide layer spontaneously grow on the outermost substrates [17]. Silanization is the most applied method of modifying silicon oxide by creating a uniform self-assembled monolayer (SAM) of silanol groups, which can further conjugate biomolecules to form a functional biointerface.…”

Overview of CMOS image sensor use in molecular diagnostics

“…Generally, CMOS sensor surface modification can be prepared by various methods such as silanization, esterification, phosphorization, hydroxysilylation by using APTES, APDMES, APMS, and SiO 2 [84]. And the modified surfaces have been capable of immobilizing the proteins and other biomolecules.…”

SOI-Nanowire Biosensors for High-Sensitivity Protein and Gene Detection

“…This approach uses a reaction between surface groups (Si-H) and organic substances with unsaturated terminal carbon bonds (alkenes and alkanes) necessary for forming Si-C bonds. Due to such bonds formed on NW surface, the functional carbon-reagent monolayer [11,21] capable of covalent binding of proteins was obtained. The formation of a monolayer, not a multi-layer film, is an advantage of the hydroxylation method as intended for NW surface functionalization.…”

“…Yet, stability of NW-surface functional layers involving aldehyde groups is rather low because the layer undergoes oxidation with atmospheric oxygen or with oxygen dissolved in the solutions. That is why nanowires functionalized in this way need to be used immediately after the functionalization procedure [21]. During silanization performed with the help of APTES, the terminal silanol groups are substituted with aminogroups capable of binding with aldehyde, carboxyl, epoxyor succinimide cross-linker groups, the special reagents making probing molecules covalently immobilized on modified NW surface (Fig.…”