Investigation into the Effect of Varied Functional Biointerfaces on Silicon Nanowire MOSFETs

Abstract

A biocompatible and functional interface can improve the sensitivity of bioelectronics. Here, 3-aminopropyl trimethoxysilane (APTMS) and 3-mercaptopropyl trimethoxysilane (MPTMS) self-assembled monolayers (SAMs) were independently modified on the surface of silicon nanowire metal-oxide-semiconductor field effect transistors (NW-MOSFETs). Those SAMs-modified silicon NW-MOSFETs were used to discriminate various pH solutions and further verify which modified regime was capable of providing better electrical signals. The APTMS-SAM modified NW-MOSFETs showed better electrical responses in pH sensing. Biomolecules on APTMS-SAM modified NW-MOSFETs also gave better signals for the corresponding proteind in physiological buffer solutions. Atomic force microscopy (AFM) clarified those electrical phenomena and found biomolecules on APTMS-SAM were relatively uniformly modified on NW-MOSFETs. Our results showed that more uniform modification contributed to better signal response to protein interactions in physiological buffer solutions. It suggests that suitable surface modifications could profoundly affect the sensing response and sensitivity.

Research Update: Nanoscale surface potential analysis of MoS2 field-effect transistors for biomolecular detection using Kelvin probe force microscopy

“…In Figures 2(d), 2(f), and 2(h), an individual PSA antibody is imaged as a green dot with a height of less than 3 nm, which is consistent with previous studies. 37 Despite the low concentration (1 pg/ml), the PSA antibody is clearly shown in the height and SP images. In an SP map of a PSA antibody on the MoS 2 bioFET, the antibody has positive SP (∼200 mV) due to the relatively low work function of MoS 2 .…”

Effect of silane/amine-based dopants on polymer-metal interaction of sub-surface silver nanoparticulate films

“…These films are flexible and depending on the polymer substrate they are stretchable too. These films find applications in the field of flexible electronics [3,46,47], bio-compatible devices [48,49], photovoltaics [50], OLEDs [51], solar cells [52][53][54], EMI shielding [55] food packaging [56], biomedical applications in imaging, cancer therapies and drug delivery [57], biosensors [58], piezoelectric energy harvester [59], solar energy generation [60], etc. The future scope of this work can be extended to the detailed study of APTMS, MPTMS and their combined effects, respectively, in tuning the electrical, optical properties of the sub-surface particulate films for the flexible electronics applications and testing their suitability for the potential futuristic device development.…”

Hybrid Silicon Nanowire Devices and Their Functional Diversity

“…For example, an amino‐surface can be further modified with succinic anhydride, whose ring structure will spontaneously open in the aqueous environment resulting in a carboxylated surface. Further, a carboxylated surface can be activated using carbodiimide chemistry in order to bind amino‐containing molecules …”