Organic Sensor for the Detection of Ammonium

Laghlimi, Charaf; Ma, Smaini; Maallah, R; Touzara, Sakina; S, El Qouatli; Chtaini, Abdelilah

doi:10.4172/2155-6210.1000239

Cited by 7 publications

(9 citation statements)

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“…Therefore, multibiomarkers characterization for single EVs has become more and more popular. [ 261,277 ] United biochemical characterization of EVs for proteins and miRNAs has attracted a lot of attention. Tayebi et al described a microfluidic chip with trapping arrays for capturing microbeads enriched with exosomes at a single‐particle level ( Figure a).…”

Section: Biochemical Characterization Techniques For Single Evsmentioning

confidence: 99%

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization

Chen

Lin

Cheng

et al. 2023

Adv Healthcare Materials

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Extracellular vesicles (EVs) are nanoscale membrane vesicles, which contain a wide variety of cargo such as proteins, miRNAs, and lipids. A growing body of evidence suggests that EVs are promising biomarkers for disease diagnosis and therapeutic strategies. Although the excellent clinical value, their use in personalized healthcare practice is not yet feasible due to their highly heterogeneous nature. Taking the difficulty of isolation and the small size of EVs into account, the characterization of EVs at a single‐particle level is both imperative and challenging. In a bid to address this critical point, more research has been directed into a microfluidic platform because of its inherent advantages in sensitivity, specificity, and throughput. This review discusses the biogenesis and heterogeneity of EVs and takes a broad view of state‐of‐the‐art advances in microfluidics‐based EV research, including not only EV separation, but also the single EV characterization of biophysical detection and biochemical analysis. To highlight the advantages of microfluidic techniques, conventional technologies are included for comparison. The current status of artificial intelligence (AI) for single EV characterization is then presented. Furthermore, the challenges and prospects of microfluidics and its combination with AI applications in single EV characterization are also discussed. In the foreseeable future, recent breakthroughs in microfluidic platforms are expected to pave the way for single EV analysis and improve applications for precision medicine.

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Section: Biochemical Characterization Techniques For Single Evsmentioning

confidence: 99%

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization

Chen

Lin

Cheng

et al. 2023

Adv Healthcare Materials

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“…12b). 187 The silver nanoparticle SPR sensors also share a shapely enhancement principle, even yielding higher sensitivity due to better coupling effects when immobilized on SPR sensing membranes. 188 Magnetic nanoparticles have a biological separation function, and for physiological mechanisms with complex composition and high viscosity, magnetic nanoparticles can effectively separate the substances to be analyzed in them using an external magnetic field (Fig.…”

Section: Chemical Modification Often Involves the Introduction Of Che...mentioning

confidence: 99%

A review of nanomaterials for biosensing applications

Li,

Wang,

Zhong

et al. 2024

J. Mater. Chem. B

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“…Among those three targets, EVs show the merits of a wide range of cargoes, 4,5 high abundance in plasma, 6 and the protection of the enclosed molecules from degradation 7 . Hence, many studies have highlighted that EVs derived from various body fluids (e.g., blood, urine, peritoneal lavages, cerebrospinal fluid) could be used in the early detection of different human cancers, such as colorectal cancer (CRC), 8–10 prostate cancer (PCa), 11–13 breast cancer, 14–16 etc.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics

Bai

et al. 2023

VIEW

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Extracellular vesicles (EVs) become one of the most important sources of cancer biomarkers during the past decade due to their wide distribution in body fluids and physiological stability. Previous studies mainly focused on nucleic acids and proteins, while lipids and metabolites were largely neglected. Noticeably, many of those micromolecules exhibited a high abundance in EVs. Revealing the metabolomics and lipidomics of EVs would provide more comprehensive information for biomarker discovery. With the rapid development of mass spectrometry (MS) facilities, MS‐based micromolecule detection has become an emerging technique for EVs studies. Increasing evidence demonstrated the presence of EV‐associated metabolites and lipids in different types of samples (e.g., cell, urine, serum, stool), which exhibited promising performance in cancer diagnosis, prognosis, and prediction of treatment responses. This review aims to summarize advances in micromolecule profiling of EVs for cancer biomarker discovery, with an emphasis on MS‐based metabolomic and lipidomic analytical techniques. Challenges in this field, including the minimum sample quantity, normalization methods, and compound identifications, are also discussed along with possible solutions.

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Organic Sensor for the Detection of Ammonium

Cited by 7 publications

References 0 publications

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization

A review of nanomaterials for biosensing applications

Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics

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