Organic selenium supplementation increases muscle selenium content in growing lambs compared to inorganic source

Paiva, Fernando Fernandes; Netto, Arlindo Saran; Correa, Lísia Bertonha; Silva, Thiago Henrique da; Guimarães, I.C.S.B.; Claro, Gustavo Ribeiro Del; Cunha, José Aparecido da; Zanetti, Marcus Antônio

doi:10.1016/j.smallrumres.2019.04.008

Cited by 19 publications

(15 citation statements)

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“…It is known that selenomethionine increases the bioavailability of Se supplements since the mechanism of absorption of both methionine and selenomethionine is the same, and selenomethionine is nonspecifically incorporated into body proteins, replacing standard methionine [ 32 ]. These results agree with Paiva et al [ 33 ], who supplemented lambs with different Se sources and levels and found a higher Se content in the muscle of lambs supplemented with 0.8 mg/kg DM of selenomethionine. However, the serum Se content was higher in all treatments compared to control, regardless of the source.…”

Section: Discussionsupporting

confidence: 93%

“…It is known that selenium is an essential constituent of GSH-px [ 16 ], and a higher activity of GSH-Px was expected for the groups treated with an additional dosage of selenium (FO plus SeE and SeE). Although organic sources of selenium are more bioavailable [ 32 ], the synthesis of selenoenzymes is quicker from an inorganic source, because this form can be rapidly biotransformed into selenocisteyne, the principal amino acid precursor of selenoenzymes [ 33 , 48 ], when compared to the organic selenium form, which can explain the lack of influence of selenium supplementation on GSH-Px activity. However, GSH-Px can also be an indicator of oxidative stress and of antioxidant capacity [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Castor and Cashew Nut Shell Oils, Selenium and Vitamin E as Antioxidants on the Health and Meat Stability of Lambs Fed a High-Concentrate Diet

et al. 2020

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Functional oils are known for their compounds with antioxidant, antimicrobial and anti-inflammatory properties, and are used in ruminant nutrition as alternatives to chemicals in order to improve performance. This study aimed to compare the influence of castor and cashew nut shell oils with pure organic selenium (hydroxy-selenomethionine) plus vitamin E, which are known and well-stablished antioxidants, on the performance traits, shelf life and microbial quality of the meat, physiological functions and oxidative stress control of lambs. Thirty-two Dorper x Santa Ines lambs (initial bodyweight of 22.42 ± 3.9 kg and 60 days of age) were submitted to a diet consisting of Cynodon dactylon hay (6%) and concentrate (94%). The animals were divided into four treatments: control, without additives; functional oils (FO), 0.50 g/kg DM of castor and cashew nut shell oils; hydroxy-selenomethionine and vitamin E (SeE), 0.50 mg/kg of organic selenium and 100 IU/kg DM of vitamin E; FO plus SeE, at the same doses as the other groups. Blood samples were collected after 1, 30 and 53 days on feed. After 54 days, the lambs were slaughtered and rumen health, carcass and meat traits, shelf life, and microbiological quality were evaluated. There were no differences in performance or carcass traits. A higher muscle and serum Se concentration (p < 0.0001), lower lipid peroxidation in meat during display (p < 0.0001), and a lower count of psychrotrophic microorganisms on day 5 were observed in the SeE and FO plus SeE groups. The treatments reduced the counts of Enterobacteriaceae, and Staphylococcus spp. FO animals showed higher GSH-Px activity on day 30, while the peroxidase activity was higher in FO plus SeE animals (p = 0.035). SeE and FO plus SeE animals had lower serum ALT and AST levels. Functional oils improved the microbiological quality of meat. Hydroxy-selenomethionine and vitamin E prevented oxidative stress, lipid peroxidation, and microbial spoilage.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of Castor and Cashew Nut Shell Oils, Selenium and Vitamin E as Antioxidants on the Health and Meat Stability of Lambs Fed a High-Concentrate Diet

et al. 2020

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“…In this context, mineral supplementation specific to the sheep species was essential and it was recommended that it be offered throughout the year, particularly in young animals. According different authors, animal diets are usually supplemented with Se in order to provide adequate amounts of different essential trace elements and to prevent Se deficiency disorders (Xun et al, 2012;Hefnawy et al, 2014;Paiva et al, 2019;Nedelkov et al, 2020). Considering the serious impact on the productive efficiency of the affected animals and the death of animals in the herd, deficiency should be avoided, with mineral supplementation in regions with Se deficiency, as well as in animals with deficiency.…”

Section: Clinical-epidemiological Aspectsmentioning

confidence: 99%

Nutritional muscular dystrophy in lambs reared on pasture in semiarid region of Brazil

Júnior

Olinda

Filho

et al. 2020

RSD

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This article presents important data on the diagnosis of nutritional muscular dystrophy (NMD) in sheep reared in the semiarid region of Northeast Brazil, with a focus on medical clinic data, nutritional management, anatomopathological aspects and quantification of serum selenium by highly sensitive analytical methodology. The semiarid region of Brazil is of great importance in the creation of small ruminants and many diseases that affect herds are related to failures in nutritional management, sanitary measures, periods of greater drought or low rainfall, little availability of native forage at certain times of the year and lack of supplementation with energy nutrients, proteins and minerals. The lack of publications on outbreaks of selenium deficiency demonstrates the importance of diagnosing in this area. The mean concentration of Se in the serum from the lambs was very low (2.52±1.02µg/L). The findings in the skeletal muscles are compatible with the characteristics observed in NMD, characterized by necrosis and calcification of myofibrils. In addition, necrotizing vasculitis in hepatic arterioles and hepatocellular coagulation necrosis in hepatocytes were observed, probably triggered by lipid peroxidation of cell membranes. The lambs from this outbreak, reared on pasture in the semiarid region, presented low serum Se concentration, with clinical and anatomopathological manifestation of NMD. Thus, supplementation with Se in the diet should be recommended regularly to avoid the appearance of new cases. Serum Se levels are useful indicators for the diagnosis of nutritional muscular dystrophy in lambs, associated with clinical and anatomopathological data.

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“…Selenium (Se) has an important role for human and animal health due to its antioxidant and antitumor properties, protection against drug-induced toxicity, regulation of thyroid gland function, prevention of inflammatory diseases, and also acting in animal growth and performance [ 8 , 9 , 10 , 11 ]. Low levels of Se have been associated with cardiovascular diseases and immune dysfunction [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Animals can consume Se in both organic and inorganic form, even though organic Se has a higher bioavailability for organisms [ 11 , 15 ]. Furthermore, the organic form of Se-enriched yeast can enhance the vaccine conferred immune response against the influenza virus in chicken [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

A New Approach for the Production of Selenium-Enriched and Probiotic Yeast Biomass from Agro-Industrial by-Products in a Stirred-Tank Bioreactor

et al. 2020

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The production of biomolecules using agro-industrial by-products as feedstock is a growing trend worldwide. Selenium (Se) is a trace element essential for health, and the Se-enrichment of yeast biomass can enhance its benefits. This study investigated the feasibility of the production of Saccharomyces cerevisiae Se-enriched biomass using a medium composed of corn bran and soybean bran acid hydrolysates as carbon and nitrogen sources in a stirred-tank reactor. After hydrolysis, hydrolysates presented complex composition and high concentrations of sugars, proteins, and minerals. The use of a stirred-tank bioreactor leads to the production of 9 g/L S. cerevisiae biomass enriched with 236.93 μg/g Se, and 99% cell viability. Likewise, the combination of sugarcane molasses and soybean bran hydrolysate was effective for cell growth of a probiotic strain of S. cerevisiae with a 24.08% β-glucan content. The results demonstrated that starchy acid hydrolysates are low-cost and efficient substrates for the production of yeast biomass and derivate products and may contribute to further studies for a sustainable development of biorefinery technologies.

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Organic selenium supplementation increases muscle selenium content in growing lambs compared to inorganic source

Cited by 19 publications

References 40 publications

Effect of Castor and Cashew Nut Shell Oils, Selenium and Vitamin E as Antioxidants on the Health and Meat Stability of Lambs Fed a High-Concentrate Diet

Effect of Castor and Cashew Nut Shell Oils, Selenium and Vitamin E as Antioxidants on the Health and Meat Stability of Lambs Fed a High-Concentrate Diet

Nutritional muscular dystrophy in lambs reared on pasture in semiarid region of Brazil

A New Approach for the Production of Selenium-Enriched and Probiotic Yeast Biomass from Agro-Industrial by-Products in a Stirred-Tank Bioreactor

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