BackgroundGlobal warming, climate change, environmental stress and population increase have threatened food security and increased food production demand. Increasing Rice productions could be a better solution to solve or at least decrease the severity of the global food crisis. The modern rice cultivation techniques have been insufficient for sustainable rice production. So, Qiangdi 863 nano synergid is hypothesized to enhance the early growth of rice, rice physiology, grain yield, and grain quality. ResultsThe present study was carried out to determine the role of Qiangdi 863 nano synergid on the growth and yield of one Chinese rice variety Zhongzao 39 and four Pakistani rice varieties KSK 133, KS 282, Super basmati, and PK 1121 aromatic. Field experiments were conducted during the years 2017, 2018, and 2019. Appling nano-treated water enhanced the germination rate along with radicle and plumule lengths and improved the photosynthesis rate, SPAD value in rice leaves for all five varieties. The results showed that nano-treated water improved the anti-oxidant Catalase activity (CAT), Superoxide Dismutase (SOD) Peroxide (POD) production, declined Malondialdehyde (MDA content), enhanced endogenous Salicylic acid (SA), Jasmonates (JA) Brassinosteroids (BR) hormonal concentration and yield parameters of rice in 2017, 18 and 19 years of data. ConclusionThese findings indicate that nano synergids can be effectively used for rice cultivation in different environmental conditions (China and Pakistan). This is the first reported application of Qiangdi 863 nano synergid in Pakistani rice varieties with effective outcomes highlighting significant results in KSK 133.