Organic montmorillonite produced an interlayer locking effect in a polymer scaffold to enhance interfacial bonding

Shuai, Cijun; Yu, Li; Feng, Pei; Zhong, Yan; Zhao, Zhenyu; Chen, Ze‐Yu; Yang, Wenjing

doi:10.1039/d0qm00254b

Cited by 70 publications

(24 citation statements)

References 63 publications

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“…At present, there are mainly two methods for evaluating the biological performances of biomaterials. One is in vitro cell culture, in which biomaterials or their extracts are cultured with various cells to study the effects of biomaterials on cell growth, adhesion, proliferation and metabolism [169][170][171]. The other is in vivo experiment, in which biomaterial is implanted into an animal body, such as rabbit or mouse, and the implant and the surrounding tissue are taken out in stages to perform histological examination.…”

Section: Biological Properties Of Biocermetsmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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As two promising biomaterials for bone implants, biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity; while bioceramics are known for good biocompatibility or even bioactivity but limited by their high brittleness. Biocermets, a kind of composites composing of bioceramics and biomedical metals, have been developed as an effective solution by combining their complementary advantages. This paper focused on the recently studied biocermets for bone implant applications. Concretely, biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase percentages. Their characteristics were systematically summarized, and the fabrication methods for biocermets were reviewed and compared. Emphases were put on the interactions between bioceramics and biomedical metals, as well as the performance improvement mechanisms. More importantly, the main methods for the interfacial reinforcing were summarized, and the corresponding interfacial reinforcing mechanisms were discussed. In addition, the in vitro and in vivo biological performances of biocermets were also reviewed. Finally, future research directions were proposed on the advancement in component design, interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

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Section: Biological Properties Of Biocermetsmentioning

confidence: 99%

Advances in biocermets for bone implant applications

et al. 2020

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“…Among the biodegradable polymers, poly (glycolic acid) (PGA) is a FDA-approved polymer with a relatively fast degradation rate [ 21 ]. The degradation rate of PGA is typically a few weeks for complete degradation due to its strong hydrophilicity [ 22 , 23 ]. PGA might degrade rapidly and produce a lot of pores in the polymer matrix when the HAP/PGA/PLLA scaffold is immersed in the body fluid environment, which will be beneficial to the exposure of HAP from matrix.…”

Section: Introductionmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

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The incorporation of hydroxyapatite (HAP) into poly- l -lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone. While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body fluid. In this study, biodegradable polymer poly (glycolic acid) (PGA) was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the degradation. The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3% to 25.0% after immersion for 28 days, owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains. Moreover, a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix, which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite growth. Cytocompatibility tests exhibited a good osteoblast adhesion, spreading and proliferation, suggesting the scaffold provided a suitable environment for cell cultivation. Furthermore, the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue, and both ends of defect region were bridged after 8 weeks of implantation.

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“…Poly-l-lactic acid (PLLA) has become one of the main bone scaffold materials due to its advantages of good biocompatibility and easy processing [ 1 , 2 , 3 ]. Nevertheless, the low cellular activity limits its application in bone tissue engineering due to the lacking of active functional groups and weak cell affinity [ 4 , 5 , 6 , 7 ]. For enhancing cellular activity, researchers have added various cell growth factors, such as bone morphogenetic protein (BMP), transforming growth factor-beta (TGF-β), fibroblast growth factor, and so on [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe3O4 nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe3O4 nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe3O4 presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe3O4 nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe3O4 scaffold with good magnetic properties is of great potential for bone tissue engineering applications.

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Organic montmorillonite produced an interlayer locking effect in a polymer scaffold to enhance interfacial bonding

Abstract: KH550 organic modified MMT was incorporated into PCL to enhance the interfacial bonding and restricted the movement of PCL molecular chains in galleries through the interlayer locking effect.

Cited by 70 publications

References 63 publications

Advances in biocermets for bone implant applications

Advances in biocermets for bone implant applications

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

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