Organic–Inorganic Composites for Bone Drug Delivery

Soundrapandian, Chidambaram; Sa, Biswanath; Datta, Someswar

doi:10.1208/s12249-009-9308-0

Cited by 59 publications

(40 citation statements)

References 76 publications

(124 reference statements)

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“…A short review on this specific topic was recently published by Soundrapandian et al 122 Most of these drugdelivery systems are based on the combination of different polymers with bioglass or calcium phosphates. Even if natural polymers are more suitable, a lot of composite materials based on synthetic polymers, such as polycaprolactone, poly(d,llactide), polylactideco glycolide (PLGA), or polymethyl methacrylate, have been also regarded with increasing interest.…”

Section: Multifunctional Materialsmentioning

confidence: 99%

“…Even if natural polymers are more suitable, a lot of composite materials based on synthetic polymers, such as polycaprolactone, poly(d,llactide), polylactideco glycolide (PLGA), or polymethyl methacrylate, have been also regarded with increasing interest. [122][123][124] The enhanced sta bility of synthetic polymers in comparison with natural ones explains the higher number of composite materials based on synthetic polymer matrices. Further, the possibility of tailor ing the composition of synthetic polymers enables a broader range of properties to be obtained for the final composites, including mechanical properties, drugrelease rate, etc.…”

Section: Multifunctional Materialsmentioning

confidence: 99%

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Multifunctional materials for bone cancer treatment

Marques¹,

Ferreira²,

Andronescu³

et al. 2014

IJN

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The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen–hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

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Section: Multifunctional Materialsmentioning

confidence: 99%

Section: Multifunctional Materialsmentioning

confidence: 99%

Multifunctional materials for bone cancer treatment

Marques¹,

Ferreira²,

Andronescu³

et al. 2014

IJN

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“…quinolones, the rate of drug release depends on the porosity of the matrix and on dissolution of the drug in the matrix (Allababidi & Shah, 1998). However, insufficient release of antibiotics on the basis of time and concentration could lead to development of resistant strains and growth of microorganisms on the surface of the scaffolds (Soundrapandian et al, 2009). …”

Section: Antibiotic Selectionmentioning

confidence: 99%

“…However, it is from the year 2000 that research on local delivery of antibiotics to bone has gained considerable attention. Note that the numbers of publications in the last five years are double and decuple published in earlier decades (Soundrapandian et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Local Antibiotic Therapy in the Treatment of Bone and Soft Tissue Infections

Tsourvakas¹

2012

Selected Topics in Plastic Reconstructive Surgery

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“…The development of biocompatible drug-releasing materials and appropriate models to study drug release from these systems, and their effectiveness in bone prior to in vivo study, are recognized as critical issues to be addressed. 8,9 Numerous biomaterials, either natural or synthetic, and either biodegradable or biologically inert, such as polymethyl methacrylate, poly(lactic-co-glycolic acid), collagen, hyaluronan, chitosan, fibrin, silk, hydroxyapatite, ceramics and injectable calcium phosphate cements, in the form of membranes, granules, hydrogels, matrices, coatings, fibers, sponges, and foams, have been explored in recent years as implants for the delivery of bone active agents. [10][11][12][13][14][15] These materials are mostly amorphous, with a large variation of porosity and nonreproducible preparation, which in turn makes the bone therapy nonreproducible.…”

Section: Introductionmentioning

confidence: 99%

Characterization of drug-release kinetics in trabecular bone from titania nanotube implants

Khalid²,

Gulati³

et al. 2012

IJN

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Purpose: The aim of this study was to investigate the application of the three-dimensional bone bioreactor for studying drug-release kinetics and distribution of drugs in the ex vivo cancellous bone environment, and to demonstrate the application of nanoengineered titanium (Ti) wires generated with titania nanotube (TNT) arrays as drug-releasing implants for local drug delivery Methods: Nanoengineered Ti wires covered with a layer of TNT arrays implanted in bone were used as a drug-releasing implant. Viable bovine trabecular bone was used as the ex vivo bone substrate embedded with the implants and placed in the bone reactor. A hydrophilic fluorescent dye (rhodamine B) was used as the model drug, loaded inside the TNT-Ti implants, to monitor drug release and transport in trabecular bone. The distribution of released model drug in the bone was monitored throughout the bone structure, and concentration profiles at different vertical (0-5 mm) and horizontal (0-10 mm) distances from the implant surface were obtained at a range of release times from 1 hour to 5 days. Results: Scanning electron microscopy confirmed that well-ordered, vertically aligned nanotube arrays were formed on the surface of prepared TNT-Ti wires. Thermogravimetric analysis proved loading of the model drug and fluorescence spectroscopy was used to show drug-release characteristics in-vitro. The drug release from implants inserted into bone ex vivo showed a consistent gradual release of model drug from the TNT-Ti implants, with a characteristic threedimensional distribution into the surrounding bone, over a period of 5 days. The parameters including the flow rate of bone culture medium, differences in trabecular microarchitecture between bone samples, and mechanical loading were found to have the most significant influence on drug distribution in the bone. Conclusion: These results demonstrate the utility of the Zetos™ system for ex vivo drugrelease studies in bone, which can be applied to optimize the delivery of specific therapies and to assist in the design of new drug delivery systems. This method has the potential to provide new knowledge to understand drug distribution in the bone environment and to considerably improve existing technologies for local administration in bone, including solving some critical problems in bone therapy and orthopedic implants.

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Organic–Inorganic Composites for Bone Drug Delivery

Cited by 59 publications

References 76 publications

Multifunctional materials for bone cancer treatment

Multifunctional materials for bone cancer treatment

Local Antibiotic Therapy in the Treatment of Bone and Soft Tissue Infections

Characterization of drug-release kinetics in trabecular bone from titania nanotube implants

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