Organic Electrochemical Transistors/SERS-Active Hybrid Biosensors Featuring Gold Nanoparticles Immobilized on Thiol-Functionalized PEDOT Films

Chou, Jia-An; Chung, Chieh-Lin; Ho, Po-Cheng; Luo, Chun-Hao; Tsai, Yu-Han; Wu, Chung-Kuan; Kuo, Chien-Nan; Hsiao, Yu-Sheng; Yu, Hsiao‐hua; Chen, Peilin

doi:10.3389/fchem.2019.00281

Cited by 19 publications

(18 citation statements)

References 38 publications

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“…Our work rises above the state of the art by combining an efficient electronic transducer with a structural probe to achieve high sensitivity and gain insight on the molecular interactions taking place upon sensing. Although the use of SERS on biological fluids in OECTs has been introduced (Chou et al, ), differing from previous studies, this is the first time that the in situ resonance Raman spectroscopy has been applied to operational OECTs for metabolite sensing via direct structural changes in the CP (PEDOT:PSS). We first define the vibrational modes and Raman signatures sensitive to PEDOT:PSS doping level and chemical structure.…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Pappa²,

Pitsalidis³

et al. 2019

Biotech & Bioengineering

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A large amount of research within organic biosensors is dominated by organic electrochemical transistors (OECTs) that use conducting polymers such as poly(3,4‐ethylene dioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS). Despite the recent advances in OECT‐based biosensors, the sensing is solely reliant on the amperometric detection of the bioanalytes. This is typically accompanied by large undesirable parasitic electrical signals from the electroactive components in the electrolyte. Herein, we present the use of in situ resonance Raman spectroscopy to probe subtle molecular structural changes of PEDOT:PSS associated with its doping level. We demonstrate how such doping level changes of PEDOT:PSS can be used, for the first time, on operational OECTs for sensitive and selective metabolite sensing while simultaneously performing amperometric detection of the analyte. We test the sensitivity by molecularly sensing a lowest glucose concentration of 0.02 mM in phosphate‐buffered saline solution. By changing the electrolyte to cell culture media, the selectivity of in situ resonance Raman spectroscopy is emphasized as it remains unaffected by other electroactive components in the electrolyte. The application of this molecular structural probe highlights the importance of developing biosensing probes that benefit from high sensitivity of the material's structural and electrical properties while being complimentary with the electronic methods of detection.

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Section: Introductionmentioning

confidence: 99%

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Pappa²,

Pitsalidis³

et al. 2019

Biotech & Bioengineering

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“…66 Owing to their ionic–electronic coupling, mixed conductors in OECTs are capable of substantial current amplification in the presence of the analyte in question, which gives rise to satisfying sensitivity of OECT at a low operational voltage in the aqueous environment. 4,67…”

Section: Organic Electrochemical Transistors: Fundamental Concepts Bi...mentioning

confidence: 99%

The effect of side chain engineering on conjugated polymers in organic electrochemical transistors for bioelectronic applications

Kukhta

Marks

et al. 2022

J. Mater. Chem. C

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“…Enhanced wettability of the semiconductor can lead to more uniform coverage on the substrate, which is specially significant for application for large-scale, organic electronics device on flexible substrate. Fourth, the addition of nanoparticle based additives can find application in other organic electronic devices such as biosensors [78,79].…”

Section: Nanoparticle Based Additivesmentioning

confidence: 99%

Nanoparticles for organic electronics applications

Zhang

2020

Mater. Res. Express

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Recently, the research in solution-based, small-molecule organic semiconductors has achieved great progress, although their application in organic electronics devices is still restricted by a variety of issues, including crystal misorientation, morphological nonuniformity and low charge-carrier mobility. In order to overcome these issues, hybrid material systems that incorporate both organic semiconductors and additives have been successfully demonstrated to control crystal growth and charge transport of the organic semiconductors. In this work, we first review the recent advances in the charge-carrier mobility of the organic semiconductors, followed by a comparison of the different additives that have been reportedly blended with the semiconductors, including polymeric additives, small-molecule additives and nanoparticle based additives. Then we will review the important nanoparticles employed as additives to blend with solution-based, organic semiconductors, which effectively improved the semiconductor crystallization, enhanced film uniformity and increased charge transport. By discussing specific examples of various well-known organic semiconductors such as 6, 13-bis (triisopropylsilylethynyl) pentacene (TIPS pentacene), we demonstrate the essential relationship among the crystal growth, semiconductor morphology, dielectric properties, and chargecarrier mobilities. This work sheds light on the implementation of nanoparticle additives in highperformance organic electronics device application. the application of the organic semiconductor in thin-film transistor and other electronics device fabrication. Throughout the discussion of these specific examples that mainly involve small-molecule organic semiconductors, we showcase that this work can be used to control the crystallization and electrical performance of other newly-discovered, high-performance, semiconducting materials. Advances in organic electronicsIn this section, we will review the various advances in charge-carrier mobilities and device application that have been recently achieved in the field of organic electronics. The following discussion will be mainly focused on various solution-processed, small-molecule, organic semiconductors.The mobilities in solution-processed, small-molecule, organic semiconductors have been reported to be compared to or even far surpass the mobility of amorphous silicon. For example, Asare-Yeboah et al developed a temperature-based method which exposed the substrate to a gradient temperature and induced a solubility difference of a p-type small-molecule semiconductor 6, 13-bis (triisopropylsilylethynyl) pentacene (TIPS pentacene) [18]. TIPS pentacene crystals grew from the lower temperature side of the substrate towards the higher temperature side, forming well-aligned ribbons across the whole substrate. A mobility of up to 0.5 cm 2 V −1 s −1 has been reported from the TIPS pentacene OTFTs based on an ITO/PET flexible substrate by using the temperature-based alignment technique. Wade et al demonstrated a zone casting metho...

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Organic Electrochemical Transistors/SERS-Active Hybrid Biosensors Featuring Gold Nanoparticles Immobilized on Thiol-Functionalized PEDOT Films

Cited by 19 publications

References 38 publications

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

The effect of side chain engineering on conjugated polymers in organic electrochemical transistors for bioelectronic applications

Nanoparticles for organic electronics applications

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