Organic electrochemical transistor incorporating an ionogel as a solid state electrolyte for lactate sensing

Khodagholy, Dion; Curto, Vincenzo F.; Fraser, Kevin J.; Gurfinkel, M.; Byrne, Robert; Diamond, Dermot; Malliaras, George G.; Benito‐Lopez, Fernando; Owens, Róisı́n M.

doi:10.1039/c2jm15716k

Cited by 257 publications

(229 citation statements)

References 29 publications

(27 reference statements)

Supporting

Mentioning

229

Contrasting

Order By: Relevance

“…[22] Moreover it is suitable for large-scale applications due to the reasonable price of this IL. [23] Both gels were characterised by FTIR in order to prove that polymerisation of NIPAAm in the ionic environment of EMIES takes part similarly that the one in aqueous environment.…”

Section: Gels Characterisation A) Fourier Transform Infrared Spectrosmentioning

confidence: 99%

Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators

et al. 2014

Self Cite

View full text Add to dashboard Cite

This paper reports for the first time the use of a crosslinked poly(Nisopropylacrylamide) ionogel encapsulating the ionic liquid 1-Ethyl-3-methylimidazolium ethyl sulphate as a thermoresponsive and modular microfluidic valve. The ionogel presents superior actuation behaviour over its equivalent hydrogel.The ionogel swelling and shrinking mechanisms and kinetics are investigated as well as the performance of the ionogel when integrated as a valve in a microfluidic device.The modular microfluidic valve demonstrates fully reversible on-off behaviour without failure for up to eight actuation cycles and a pressure resistance of 1100 mbar.

show abstract

Section: Gels Characterisation A) Fourier Transform Infrared Spectrosmentioning

confidence: 99%

Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…The transistor channel is typically in direct contact with an electrolyte within which a gate electrode is also present. Poly(3,4-ethylene-dioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) is a conducting polymer that is commonly employed as the active layer of OECTs, due to its easy processability, chemical tunability, and biocompatibility [26][27][28] . Solution processability of this material implies a flexibility of design essential for integration of devices with state of the art in vitro models, and indeed, incorporation of microfluidics.…”

Section: Introductionmentioning

confidence: 99%

Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring

et al. 2017

Self Cite

View full text Add to dashboard Cite

Future drug discovery and toxicology testing could benefit significantly from more predictive and multi-parametric readouts from in vitro models. Despite the recent advances in the field of microfluidics, and more recently organ-on-a-chip technology, there is still a high demand for real-time monitoring systems that can be readily embedded with microfluidics. In addition, multi-parametric monitoring is essential to improve the predictive quality of the data used to inform clinical studies that follow. Here we present a microfluidic platform integrated with in-line electronic sensors based on the organic electrochemical transistor. Our goals are twofold, first to generate a platform to host cells in a more physiologically relevant environment (using physiologically relevant fluid shear stress (FSS)) and second to show efficient integration of multiple different methods for assessing cell morphology, differentiation, and integrity. These include optical imaging, impedance monitoring, metabolite sensing, and a wound-healing assay. We illustrate the versatility of this multi-parametric monitoring in giving us increased confidence to validate the improved differentiation of cells toward a physiological profile under FSS, thus yielding more accurate data when used to assess the effect of drugs or toxins. Overall, this platform will enable high-content screening for in vitro drug discovery and toxicology testing and bridges the existing gap in the integration of in-line sensors in microfluidic devices.

show abstract

“…for rapid cell expansion) 8 , organic transistors 9 , neural prosthesis (e.g. cochlear electrodes) 10 , tissue regeneration devices (e.g.…”

Section: Introductionmentioning

confidence: 99%

Quantifying fibronectin adhesion with nanoscale spatial resolution on glycosaminoglycan doped polypyrrole using Atomic Force Microscopy

Gelmi

Higgins

Wallace

2013

Biochimica et Biophysica Acta (BBA) - General Subjects

View full text Add to dashboard Cite

The interaction of ECM proteins is critical in determining the performance of materials used in biomedical applications such as tissue regeneration, implantable bionics and biosensing. Methods: To improve our understanding of ECM protein-conducting polymer interactions, we have used Atomic Force Microscopy (AFM) to elucidate the interactions of fibronectin (FN) on polypyrrole (PPy) doped with different glycosaminoglycans. Results: We were able to classify four main types of FN interactions, including those related to 1) non-specific adhesion, 2) protein unfolding and subsequent unbinding from the surface, 3) desorption and 4) interactions with no adhesion. FN adhesion on PPy/hyaluronic acid showed a significantly lower density of surface adhesion with the adhesion restricted to nodule structures, as opposed to their peripheries, of the polymer morphology. In contrast, PPy/chondroitin sulfate showed a significantly higher density of surface adhesion to the point where the distribution of adhesion effectively masked the topography. Through conductive AFM imaging, we found that the conductive regions correlated with regions of FN adhesion. Conclusions: Given that the conductivity requires doping of the polymer, these findings suggest that FN adhesion is mediated by interactions with chondroitin sulfate and hyaluronic acid at the polymer surface and may be indicative of specific interactions due to contributions from electrostatic attraction between the FN and sulfate/anionic groups of the dopants. General significance: This study demonstrates the ability of AFM to resolve the protein-conducting polymer interactions at the molecular and nanoscale level, which will be important for interfacing these polymer materials with biological systems. This article is part of a Special Issue entitled Organic Bioelectronics -Novel Applications in Biomedicine.

show abstract

Organic electrochemical transistor incorporating an ionogel as a solid state electrolyte for lactate sensing

Cited by 257 publications

References 29 publications

Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators

Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators

Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring

Quantifying fibronectin adhesion with nanoscale spatial resolution on glycosaminoglycan doped polypyrrole using Atomic Force Microscopy

Contact Info

Product

Resources

About