Organic dots (O-dots) for theranostic applications: preparation and surface engineering

Dezfuli, Amin Shiralizadeh; Kohan, Elmira; Fateh, Sepand Tehrani; Alimirzaei, Neda; Arzaghi, Hamidreza; Hamblin, Michael R.

doi:10.1039/d0ra08041a

Cited by 13 publications

(6 citation statements)

References 357 publications

(493 reference statements)

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“…However, the emission wavelength of ODs showed the size dependent properties, it was probably excitationindependent and were given the blue luminescence and broad peak at 425 nm in this trial. We can claim that these Organic dots are ODs type II [12].…”

Section: Uv/vis and Pl Spectroscopiesmentioning

confidence: 87%

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Organic Dots-PVA as a Platform for Wound Dressing

Afkhami

Oskouie

Mohammadi

et al. 2023

Preprint

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We utilize a new nanocomposite material to give a report about a new platform for wound dressing. It is worth mentioning synergistic mixing graphene quantum dots (as a type of organic dots (ODs)) and polyvinyl alcohol (PVA) are materials participating in fabrication of the nanocomposite mentioned. We brought staphylococcus aureus as a gram-positive bacterium and pseudomonas aeruginosa as a gram-negative bacterium into play to optimize their antibacterial activity. We evaluated Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for OD/PVA nanocomposite. Our optimizations resulted as a persistent level against methicillin-resistant staphylococcus aureus (MRSA) in higher ratios of OD. Vitro studies and MTT assay were used for determination the optimum ratio of OD to PVA. We quantified burned wound infection models and the colony forming units CFUs in the burn wound which were in vivo studies by a standard colony counting method. Finally, the results show the mechanism of antibacterial activity of nanocomposite described as a contact mediated oxidative stress induction.

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Section: Uv/vis and Pl Spectroscopiesmentioning

confidence: 87%

“…Carbon-based quantum dots (CBQDs) containing graphene quantum dots (GQDs) and carbon quantum dots (CQDs) can be categorized as organic materials and name them as "organic dots (ODs)" [12].…”

Section: Introductionmentioning

confidence: 99%

Organic Dots-PVA as a Platform for Wound Dressing

Afkhami

Oskouie

Mohammadi

et al. 2023

Preprint

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“…Optical properties of CDs were widely studied since they were accidentally discovered, because the PL of various CDs was cover from UV to visible light and even near the infrared region [ 44 , 45 , 46 , 47 , 48 ]. However, the mechanisms of tunable PL properties were not clear because inconsistent experimental observations and inaccuracy definition synthesis of different approaches made the research of luminescence more complicated.…”

Section: Microstructure Properties Synthetic Methods and Biocompatibilitymentioning

confidence: 99%

“…Therefore, emissions of CDs were tunable and could cover a wide range from the visible to the near-infrared region, after the surfaces of CDs were passivated by organic or polymeric materials [24] as in Figure 1. Optical properties of CDs were widely studied since they were accidentally discovered, because the PL of various CDs was cover from UV to visible light and even near the infrared region [44][45][46][47][48]. However, the mechanisms of tunable PL properties were not clear because inconsistent experimental observations and inaccuracy definition synthesis of different approaches made the research of luminescence more complicated.…”

Section: Microstructure and Properties Of Cdsmentioning

confidence: 99%

A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

Tao

et al. 2021

Materials

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Depression has become the leading cause of disability worldwide and is a global health burden. Quantitative assessment of depression-related neurotransmitter concentrations in human fluids is highly desirable for diagnosis, monitoring disease, and therapeutic interventions of depression. In this review, we focused on the latest strategies of CD-based electrochemical biosensors for detecting a depression-related neurotransmitter. We began this review with an overview of the microstructure, optical properties and cytotoxicity of CDs. Next, we introduced the development of synthetic methods of CDs, including the “Top-down” route and “Bottom-up” route. Finally, we highlighted detecting an application of CD-based electrochemical sensors in a depression-related neurotransmitter. Moreover, challenges and future perspectives on the recent progress of CD-based electrochemical sensors in depression-related neurotransmitter detection were discussed.

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“…GOs consist of large carbon sheets without fluorescence properties. On the other hand, GQDs are smaller than GO and possess higher fluorescent properties due to their enhanced quantum yield [27]. The excellent photoluminescence property of GQDs provides the possibility of simultaneous delivery and tracking of drugs [28].…”

Section: Introductionmentioning

confidence: 99%

Curcumin loaded on graphene nanosheets induced cell death in mammospheres from MCF-7 and primary breast tumor cells

et al. 2021

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Elimination of tumor cells is still a therapeutic challenge for breast cancer (BC) in men and women. Mammospheres serve as valuable in vitro tools for evaluating tumor behavior and sensitivity to anticancer treatments. Graphene nanosheets with unique physicochemical properties have been considered as potential biomedical approaches for drug delivery, bioimaging, and therapy. Graphene oxide (GO) and graphene quantum dots (GQDs) are suitable nanocarriers for hydrophobic and low bioaccessible anti-tumor materials like curcumin. Despite extensive studies on the potential application of graphene nanosheets in medicine, our knowledge of how different cells function and respond to these nanoparticles remains limited. Here, we evaluated cell death in mammospheres from MCF-7 and primary tumor cells in response to curcumin loaded on graphene nanosheets. Mammospheres were exposed to graphene oxide-curcumin (GO-Cur) and graphene quantum dots-curcumin (GQDs-Cur), and the incidence of cell death was evaluated by Hoechst 33342/propidium iodide double staining and flow cytometry. Besides, the expression of miR-21, miR-29a, Bax, and Bcl-2 genes were assessed using RT-qPCR. We observed, GO, and GQDs had no cytotoxic effect on Kerman male breast cancer/71 (KMBC/71) and MCF-7 tumor cells, while curcumin induced death in more than 50% of tumor cells. GO-Cur and GQDs-Cur synergistically enhanced anti-tumor activity of curcumin. Moreover, GQDs-Cur induced cell death in almost all cells of KMBC/71 mammospheres (99%; p < 0.0001). In contrast, GO-Cur induced cell death in only 21% of MCF-7 mammosphere cells (p < 0.0001). Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur. Although KMBC/71 and MCF-7 tumor cells had similar clinical features and displayed similar responses to curcumin, more investigations are needed to clarify the detailed molecular mechanisms underlying observed differences in response to GO-Cur and GQDs-Cur.

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Organic dots (O-dots) for theranostic applications: preparation and surface engineering

Cited by 13 publications

References 357 publications

Organic Dots-PVA as a Platform for Wound Dressing

Organic Dots-PVA as a Platform for Wound Dressing

A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

Curcumin loaded on graphene nanosheets induced cell death in mammospheres from MCF-7 and primary breast tumor cells

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