Organic disulfide-modified folate carbon dots for tumor-targeted synergistic chemodynamic/photodynamic therapy

Abstract

Carbon dots (CDs) have great potential for cancer diagnosis and treatment. Photodynamic therapy and chemodynamic therapy are promising treatments mediated by reactive oxygen species (ROS), which have the advantage of...

Inorganic nanoparticle agents for enhanced chemodynamic therapy of tumours

“…In a similar manner, another study by Tang et al focused on addressing the challenges associated with the CDT/PDT combination, lack of tumour targeting ability and aggregation of hydrophobic photosensitizers. 111 They developed folate-based carbon dots, which were subsequently modified with a photosensitizer, pyropheophorbide-a (PPa), and an organic disulfide, 3,3′-dithiodipropionic acid (DTPA). The resulting carbon dots exhibited good water dispersibility, thereby resolving the poor solubility of folate as well as PPa.…”

Type‐I Photodynamic Therapy Induced by Pt‐Coordination of Type‐II Photosensitizers into Supramolecular Complexes

“…Moreover, solely type-I PDT is still suffered from the reoccurrence of tumor cells owing to the limited light penetration depth and ROS diffusion distance (~100 nm). [23][24][25] To solve this dilemma, self-assembled Pt-coordination complexes based on photosensitizers via simple metal coordination interactions have been developed. [26][27][28] The Pt center in the complexes could eliminate the residual tumor cells as a chemotherapeutic drug to elevate the antitumor outcomes.…”

“…However, the exploitation of these type‐I photosensitizers involved in sophisticated and tedious synthetic produces. Moreover, solely type‐I PDT is still suffered from the reoccurrence of tumor cells owing to the limited light penetration depth and ROS diffusion distance (~100 nm) [23–25] …”

Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescence imaging-guided enhanced chemodynamic/photothermal combination therapy

“…During circulation, only a small amount of nanomedicine can accumulate at the tumor site. 13 On the other hand, although H 2 O 2 is overexpressed in the tumor site, its absolute concentration is still not high enough to generate adequate OH for thoroughly killing cancer cells. 1,14,15 The low content of nanomedicine combined with limited H 2 O 2 concentration results in unsatisfactory therapeutic efficacy.…”