Organic carbonate from Calotropis procera leaves

Olea, Roberto Sigfrido Gallegos; Oliveira, A.V.; Silveira, L.M.S.; Silveira, E. R.

doi:10.1016/s0367-326x(02)00069-2

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…For decades now, chemical extracts from Calotropis procera have been shown to have ascaricidal, schizonticidal, anti-bacterial, , anthelmintic, insecticidal, antiinflammatory, , anti-diarrhoeal, larvicidal, cytotoxic , and even analgesic effects. These pleiotrophic effects are due to the fact that Calotropis procera contains numerous different chemical entities among which norditerpenic esters, pentacyclic triterpenoids, organic carbonates, a cysteine protease, histamine, alkaloids, flavonoids, sterols, and numerous types of cardenolides. − Apart from their very widely known cardiotonic steroid-related effects mediated through their binding to the Na + /K + -ATPase (the sodium pump), , cardenolides also act against a large range of cancer types. − …”

Section: Introductionmentioning

confidence: 99%

Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from Calotropis procera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance: Structure−Activity Relationship Analyses

et al. 2005

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Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with respect to its hemisynthetic chemical yield, its in vitro antitumor activity, its in vitro inhibitory influence on the Na+/K+-ATPase activity, and its in vivo tolerance. Compound 23 displayed in vitro antitumor activity on a panel of 57 human cancer cell lines similar to taxol, and higher than SN-38 (the active metabolite of irinotecan), two of the most potent drugs used in hospitals to combat cancer.

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Section: Introductionmentioning

confidence: 99%

Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from Calotropis procera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance: Structure−Activity Relationship Analyses

et al. 2005

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“…doi: 10.36877/pmmb.0000328 http://journals.hh-publisher.com/index.php/pmmb C. Procera contains cardioactive glycosides, calactin, calotropain, calotropagenin, proceroside, syriogenin, calotoxin, uscharin, uzarigenin, uscharidin, voruscharin, tannins, flavonoids, sterols, and triterpenes [34] . Other compounds found include benzoylisolineolon and benzoyllineolone [35] , procesterol, a steroidal hydroxy ketone [36] , flavonol glycosides [37] , organic carbonate with stigmasterol and sitosterol [38] .…”

Section: Phytochemical Compositionmentioning

confidence: 99%

Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco

Drioua,

Cherkani-Hassani,

El-Guourrami

et al. 2023

Prog Micobes Mol Biol

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In Morocco, traditional medicine utilizes many toxic plants for cancer treatment, despite a lack of scientific evidence supporting their effectiveness. Further research may be able to explore and discover the potential therapeutic effects of these plants' bioactive molecules with antioxidant and anticancer properties. Based on our review, we have determined that the 13 plants under examination possess various pharmacological and biological activities due to their diverse phytochemical composition. Despite their toxicity, these plants have a history of traditional use in Morocco for treating multiple diseases. Further research, including preclinical and clinical trials, should be conducted to investigate the potential therapeutic benefits of these plants. Moroccan cuisine commonly incorporates gruels, herbal drinks, and spicy beverages, which possess significant health benefits, including chemo-preventive properties and natural inhibitors against certain infections. These properties may aid in reducing the incidence of cancer and potentially have therapeutic effects in various human pathologies when consumed in appropriate amounts and in combination with a healthy lifestyle.

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UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

Juncker

Schumacher

Dicato

et al. 2009

Biochemical Pharmacology

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Despite significant progress in oncology therapeutics in the last decades, the urge to discover and to develop new, alternative or synergistic anti-cancer agents still remains. For centuries it has been known that the coarse shrub Calotropis procera is a very promising source of ascaricidal, schizonticidal, anti-bacterial, anthelmintic, insecticidal, anti-inflammatory, anti-diarrhoeal, larvicidal and cytotoxic chemicals. Different compounds like norditerpenic esters, organic carbonates, the cysteine protease procerain, alkaloids, flavonoids, sterols as well as numerous types of cardenolides have provided this plant for centuries with scientists' interest. The chemical class of cardenolides and their related bioactivity evaluation and structure-activity relationship (SAR) studies pointed out their therapeutic utility and led to the discovery of promising drug candidates. Recently the cardiotonic steroid UNBS1450 01 (derived from 2-oxovoruscharin 02) from C. procera was shown to additionally exert an anti-cancer activity. UNBS1450 01 has been proven to be a potent sodium pump inhibitor, showing anti-proliferative and cell death-inducing activities. This anti-cancer potential of UNBS1450 01 is achieved by disorganization of the actin cytoskeleton after binding to the sodium pump at the cellular membrane, by inducing autophagy-related cell death, by repressing NF-kappaB activation as well as by down-regulating c-Myc in cancer cells. We aim to review pharmacologically important chemical extracts from C. procera and focus more specifically on the anti-cancer activities of UNBS1450 01.

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Organic carbonate from Calotropis procera leaves

Cited by 8 publications

References 13 publications

Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from Calotropis procera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance: Structure−Activity Relationship Analyses

Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from Calotropis procera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance: Structure−Activity Relationship Analyses

Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco

UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

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