Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco

Drioua, Soufiane; Cherkani-Hassani, Abha; El-Guourrami, Otman; Ameggouz, Mouna; Zahidi, Ahmed; Bouyahaya, Abdelhakim; Ibrahim Shah, Sayyed; Al-Worafi, Yaser Mohammed; Ming, Long Chiau; Benzaied, Hanane; Doukkali, Anass

doi:10.36877/pmmb.a0000328

Cited by 3 publications

(2 citation statements)

References 122 publications

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“…Phytochemicals in plants have antioxidant properties and could curb oxidative stress, which helps in aging and age-related disease prevention [11,[74][75][76][77][78][79] . Other phytochemicals in khat including saponins [80,81] , flavonoids, and tannins [82] , also possessed antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans

Lim,

Alshawsh,

Alshagga

et al. 2023

Prog Micobes Mol Biol

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The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely recognised, but much remains unknown about its mode of action. This study demonstrated that exposure to high doses of KEE, cathinone, cathine and sibutramine at 12.5, 1.8, 1.8 and 1.8 mg/ml showed the most visible reduction in pharyngeal pumping rate, respectively. C. elegans showed an anomalous dynamic of reproduction rate upon exposure to these compounds but overall, showed a reduced amount of progeny. KEE, cathinone, and cathine extended the lifespan of C. elegans as compared to sibutramine and control with survival rate increments of 59.5%, 43.3%, and 15%, respectively. Quantitative RT-PCR results were insignificant, but cyp-14A3, cyp-34A9, and cyp-35A2 across all treatments were upregulated, ranging from >1 to 3-fold as compared to control. cyp genes expression could be upregulated to enhance the metabolism of khat extract, cathinone, cathine, and sibutramine in C. elegans.

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Section: Discussionmentioning

confidence: 99%

CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans

Lim,

Alshawsh,

Alshagga

et al. 2023

Prog Micobes Mol Biol

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show abstract

“…Natural products from different organisms, including microorganisms, have several biological, biochemical, and pharmacological properties [1][2][3][4] . These molecules include numerous macromolecules such as sucrose, lipids, proteins, flavonoids, alkaloids, and phenolic acids, exhibiting various bioactivities such as antioxidant, antimicrobial [5][6][7][8][9][10][11] and anticancer activities [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Bacterial Exopolysaccharides: From Production to Functional Features

Talbi,

Elmarrakchy,

Youssfi

et al. 2023

Prog Micobes Mol Biol

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Exopolysaccharides, known as bacterial EPS, are complex sugar polymers that bacteria secrete into their environment. EPSs play a crucial role in bacterial survival and proliferation by protecting cells from environmental threats. They also contribute to proper adhesion to numerous surfaces through biofilm production. Bacterial EPS display a wide range of biological activities conferred by their outstanding physical and chemical properties, which make them great candidates for medical and industrial applications. The main biological activities recorded up-to-day include antioxidant, anticancer, antiviral, anti-inflammatory, anticancer, antibacterial, immune-modulatory and chelating properties. They also can be used as thickening agents in the industry or as additives to improve soil quality in agriculture. The current review offers a thorough overview of bacterial EPS, their biosynthesis processes and regulation, and biotechnological strategies to increase their production. The review also unravels the main extraction, purification, and identification techniques and highlights the key functional features of these complex molecules.

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Comprehensive Review of Phytochemical Studies and Legalization of Cannabis in Morocco

Uwikunda,

Metouekel,

Elfahime

et al. 2024

NRFHH

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Research on cannabis and its bioactive derivatives, including cannabinoids, non-cannabinoids, and extracts, has significantly increased in recent years due to their potential therapeutic applications as demonstrated by numerous published studies. Although there is evidence of the potential efficacy of cannabinoid and non-cannabinoid compounds from cannabis in the treatment of various diseases and syndromes, further research is required to mitigate the potential damage that could result from the excessive use of cannabinoid products, particularly tetrahydrocannabinol (THC), such as psychotropic effects, addiction, cognitive deficits, cardiovascular problems, and impacts on mental health. This review describes phytochemical and biological studies on cannabis grown in Morocco, utilizing databases such as SciFinder, ScienceDirect, Scopus, Google Scholar, and PubMed to provide updated data on cannabis in Morocco. The findings of this research aim to enable investors, economic operators, researchers, and policymakers to better understand the current state of cannabis in Morocco, thereby promoting industry growth and cannabis-related innovation. Additionally, this paper includes a brief discussion on the legalization of cannabis in Morocco, highlighting the new opportunities for investment in medical cannabis. This study also underscores that much remains to be explored regarding Moroccan cannabis, from the isolation of bioactive compounds and pre-clinical studies to clinical trials and the mass production of approved cannabis-based medicines. Furthermore, the findings are intended to inform key stakeholders about the current state of cannabis in Morocco, fostering industry growth and innovation.

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Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco

Cited by 3 publications

References 122 publications

CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans

CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans

Bacterial Exopolysaccharides: From Production to Functional Features

Comprehensive Review of Phytochemical Studies and Legalization of Cannabis in Morocco

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