Organ-specific autoantibodies and autoimmune diseases in juvenile systemic lupus erythematosus and juvenile dermatomyositis patients

Aikawa, Nádia E.; Jesús, Adriana Almeida de; Liphaus, Bernadete L.; Silva, Clóvis A.; Sampaio, Magda Carneiro; Sallum, Adriana Maluf Elias

doi:10.1186/1546-0096-10-s1-a14

Cited by 28 publications

(38 citation statements)

References 17 publications

(31 reference statements)

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“…Twenty percent of the cSLE patients with CSU evaluated had autoimmune thyroid disease; this contrasts with the 7% of this endocrine abnormality previously reported in a cohort study regarding the overall cSLE population at a single center [13] . The pathophysiology of this disorder is unknown, but the immune dysregulation may be related to autoimmunity or to chronic inflammatory processes [5] .…”

Section: Discussioncontrasting

confidence: 75%

“…The presence of antithyroid antibodies, i.e. antithyroid peroxidase, antithyroglobulin and anti-TSH receptor antibody, and hypothyroidism was necessary for a diagnosis of autoimmune thyroiditis [13] . Antiphospholipid syndrome was diagnosed according to the presence of arterial and/or venous thrombosis and antiphospholipid antibodies [14] .…”

Section: Demographic Data Clinical Evaluation Disease Activity and mentioning

confidence: 99%

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Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Ferriani

Silva

Pereira

et al. 2015

Int Arch Allergy Immunol

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Background: Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demographic data, clinical manifestations, disease activity/damage, laboratory abnormalities and treatment. Methods: A retrospective multicenter cohort study (Brazilian cSLE group) was performed in 10 Pediatric Rheumatology services and included 852 cSLE patients. CSU was diagnosed according to the guidelines of the European Academy of Allergy and Clinical Immunology, the Global Allergy and Asthma European Network, the European Dermatology Forum and the World Allergy Organization. Patients with CSU (evaluated at urticaria diagnosis) and patients without CSU (evaluated at the last visit) were assessed for lupus clinical/laboratory features and treatment. Results: CSU was observed in 10/852 cSLE patients (1.17%). The median of cSLE duration at urticaria diagnosis was 0 (-3 to 5) years. Comparison of cSLE patients with and without CSU revealed a greater frequency of constitutional symptoms (40 vs. 8%, p = 0.006), reticuloendothelial system involvement (30 vs. 3%, p = 0.003), mucocutaneous (90 vs. 28%, p < 0.0001) and musculoskeletal manifestations (50 vs. 6%, p < 0.0001) and methylprednisolone pulse therapy use (60 vs. 9%, p < 0.0001) in the former group. The frequency of immunosuppressive treatment was lower in patients with CSU (p = 0.018). The median SLE Disease Activity Index 2000 (12 vs. 2, p < 0.0001) and erythrocyte sedimentation rate (40 vs. 19 mm/1st hour, p = 0.024), was higher in patients with CSU. Conclusions: To our knowledge, this is the first study with evidence that CSU may be linked to cSLE. We also demonstrated that this particular skin manifestation occurs predominantly at disease onset and is associated with lupus moderate/high disease activity without major organ involvement.

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Section: Discussioncontrasting

confidence: 75%

Section: Demographic Data Clinical Evaluation Disease Activity and mentioning

confidence: 99%

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Ferriani

Silva

Pereira

et al. 2015

Int Arch Allergy Immunol

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“…34 Auto antibodies were observed in 29% of our IgAD patients. This frequency was higher than our pediatric leprosy patients (16%) 35 and was lower than our c-SLE, juvenile dermatomyositis 36 and RASopathies 37 patients, who presented up to 93%, 59% and 52% of auto antibodies, respectively.…”

Section: Discussioncontrasting

confidence: 66%

Autoimmune diseases and autoantibodies in pediatric patients and their first-degree relatives with immunoglobulin A deficiency

Fahl

Silva

Pastorino

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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“…71 Comorbidity of Graves disease and Evans syndrome is also rare, and to the best of arthritis, SLE, or juvenile arthritis. In a study by Aikawa et al, 80 antithyroid autoantibodies were detected in 24% of patients with juvenile SLE. There were a few reports on patients with severe anemia due to pure red cell aplasia in the course of SLE, in whom accompanying diseases included hypothyroidism.…”

Section: Autoimmune Hemolytic Anemia and Evans Syndromementioning

confidence: 92%

Anemia in thyroid diseases

Szczepanek‐Parulska¹,

Hernik²,

Ruchała³

2017

Polish Archives of Internal Medicine

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Organ-specific autoantibodies and autoimmune diseases in juvenile systemic lupus erythematosus and juvenile dermatomyositis patients

Cited by 28 publications

References 17 publications

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus

Autoimmune diseases and autoantibodies in pediatric patients and their first-degree relatives with immunoglobulin A deficiency

Anemia in thyroid diseases

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