Organ Sparing Surgery for Penile Cancer: A Systematic Review

Kamel, Mohamed H.; Bissada, Nabil K.; Warford, Renee; Farias, Judy; Davis, Rodney

doi:10.1016/j.juro.2017.01.088

Cited by 75 publications

(52 citation statements)

References 48 publications

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“…Treatment of primary lesion requires surgery, with organ-sparing procedures now a standard of care whenever feasible and oncologically safe [24,25]. There are also alternatives to surgery, including topical treatments or laser ablation in low-stage and low-grade cases or radiation therapy in cases with small lesions [26][27][28][29]. Lymph node status and management have the strongest impact on patients' survival [22].…”

Section: Penile Cancermentioning

confidence: 99%

TGF-β and microRNA Interplay in Genitourinary Cancers

Bogusławska¹,

Kryst

Poletajew

et al. 2019

Cells

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Genitourinary cancers (GCs) include a large group of different types of tumors localizing to the kidney, bladder, prostate, testis, and penis. Despite highly divergent molecular patterns, most GCs share commonly disturbed signaling pathways that involve the activity of TGF-β (transforming growth factor beta). TGF-β is a pleiotropic cytokine that regulates key cancer-related molecular and cellular processes, including proliferation, migration, invasion, apoptosis, and chemoresistance. The understanding of the mechanisms of TGF-β actions in cancer is hindered by the “TGF-β paradox” in which early stages of cancerogenic process are suppressed by TGF-β while advanced stages are stimulated by its activity. A growing body of evidence suggests that these paradoxical TGF-β actions could result from the interplay with microRNAs: Short, non-coding RNAs that regulate gene expression by binding to target transcripts and inducing mRNA degradation or inhibition of translation. Here, we discuss the current knowledge of TGF-β signaling in GCs. Importantly, TGF-β signaling and microRNA-mediated regulation of gene expression often act in complicated feedback circuits that involve other crucial regulators of cancer progression (e.g., androgen receptor). Furthermore, recently published in vitro and in vivo studies clearly indicate that the interplay between microRNAs and the TGF-β signaling pathway offers new potential treatment options for GC patients.

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Section: Penile Cancermentioning

confidence: 99%

TGF-β and microRNA Interplay in Genitourinary Cancers

Bogusławska¹,

Kryst

Poletajew

et al. 2019

Cells

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“…Radical organ-sparing surgery can be implemented for a number of malignant diseases with specific indications, such as breast cancer, kidney cancer, or penile cancer [ 19 – 21 ]. The objective of applying this organ-sparing method is to improve the quality of life as well as the functional outcome.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Zhang

Yang

Wang

et al. 2018

BioMed Research International

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This study aimed to compare the oncological and renal outcomes of partial ureterectomy (PU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). UTUC patients' clinical information was reviewed, and progression-free survival (PFS), overall survival (OS), and kidney function were collected. The mean follow-up period was 59 (6–135) months in the RNU group and 34.5 (5–135) months in the PU group. The mean operation time in the PU group was 141 (64–340) min, which is significantly shorter than the RNU group (P < 0.01). Regarding kidney function at one year or two years after operation, the PU group had significantly improved mean estimated glomerular filtration rate (eGFR) levels and a remarkably decreased constitution of patients with chronic kidney disease (CKD) III or higher group (P < 0.05). There was no significant difference in PFS and OS between the RNU group and the PU group (P > 0.05). Multifactor Cox regression analysis indicated that age and the preoperative CKD stages were independent risk factors for poor kidney functions of UTUC patients. Compared to patients in RNU group, patients in PU have no significant difference in survival time but have shorter operation time, shorter hospital stay, and improved kidney functions.

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“…In general, the use of grafts is associated with donor-site morbidity and the risks of poor graft take. Many modifications with regard to the graft material have been published; however, none of them are as well established as the STSG [11] . For that reason, we chose a standardised STSG for the second procedure in order to minimise risk of graft take failure and unsatisfactory cosmetic appearance.…”

Section: Discussionmentioning

confidence: 99%

Neo-glans reconstruction for penile cancer: Description of the primary technique using autologous testicular tunica vaginalis graft

Weibl

Plank

Hoelzel

et al. 2018

Arab Journal of Urology

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Partial penectomy (glansectomy with/or without distal corporectomy) is an acceptable alternative for smaller distal pT3 penile carcinoma lesions in highly motivated and compliant patients. The authors describe a novel technique of neo-glans reconstruction using a tunica vaginalis (TV) testis allograft. However, due to an unclear resection margin on final histology, the patient underwent re-do surgery with a neo-glans revision using the well-established mesh split-thickness skin graft (STSG) technique. The penile length was preserved and the penile and bulbar part of the urethra was additionally mobilised in order to obtain a natural and aesthetic result for the meatus.Neo-glans reconstruction with TV coverage may be another promising alternative, which certainly requires further evaluation. We believe that the donor-site associated morbidity is minimal when compared to other harvesting sites. However, this is just an assumption, because direct comparison data on grafting techniques and neo-glans reconstruction are not available. Nevertheless, we think that for re-do procedures a standardised approach using a STSG technique should be the treatment method of choice.

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Organ Sparing Surgery for Penile Cancer: A Systematic Review

Abstract: In properly selected patients with penile cancer organ sparing surgery provides comparable oncologic outcomes to conventional techniques, including total and subtotal amputations. Many patients are able to urinate while standing and a significant number are able to have intercourse.

Cited by 75 publications

References 48 publications

TGF-β and microRNA Interplay in Genitourinary Cancers

TGF-β and microRNA Interplay in Genitourinary Cancers

Comparison of Radical Nephroureterectomy and Partial Ureterectomy for the Treatment of Upper Tract Urothelial Carcinoma

Neo-glans reconstruction for penile cancer: Description of the primary technique using autologous testicular tunica vaginalis graft

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