Neo-glans reconstruction for penile cancer: Description of the primary technique using autologous testicular tunica vaginalis graft

Weibl, Peter; Plank, Christina; Hoelzel, Rudolf; Hacker, Stefan; Remzi, Mesut; Huebner, Wilhelm

doi:10.1016/j.aju.2018.02.002

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Moreover, only one investigation reported potential effect modifiers, and further studies are warranted which explore whether effects of partial penectomy on sexual function differs depending upon participant characteristics. In addition, none of the studies reported whether skin grafts were used for closure, which could impact upon length, cosmetic outcome and sexual function [ 46 ]. Additional details of the surgical procedure should be reported in future investigations, and studies may be warranted which contrast surgical outcomes (including sexual function) between primary closure and autologous reconstruction with a skin graft.…”

Section: Discussionmentioning

confidence: 99%

Effects of partial penectomy for penile cancer on sexual function: A systematic review

et al. 2022

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Penile cancer is a rare but debilitating condition, which often requires aggressive treatment. Partial penectomy is considered as a treatment option when a sufficient portion of the penile shaft can be maintained to preserve functionality. This systematic review, which followed the PRIMSA guidelines, aimed to evaluate the effects of partial penectomy for penile cancer on sexual function—the maintenance of which is often a priority in patient groups—and to identify potential factors which may moderate these effects. A systematic search of PubMed, The Cochrane Library, and Open Grey as well as MEDLINE, CINAHL and Open Dissertations via EBSCOhost was conducted from inception through to 24th March, 2022. Studies were required to include adults aged ≥18 years who had undergone partial penectomy for the treatment of penile cancer, with a quantitative measure of sexual function available pre- and post-surgery. Four eligible articles were identified for inclusion in this review, three of which reported a decrease in sexual function pre- to post-surgery across all domains of the International Index of Erectile Function (IIEF) questionnaire (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction). Conversely, one study reported an increase in sexual function across IIEF domains, except for orgasmic function, which decreased, pre- to post-surgery. Greater penile length was associated with higher post-operative sexual function, whilst increasing age and higher anxiety levels were associated with lower post-operative sexual function levels in one study. Despite the overall drop in sexual function, many patients were still able to maintain satisfactory sex lives following partial penectomy. Given the limited research in this area and small sample sizes across studies, additional well-controlled investigations are warranted to provide further evidence on the effects of partial penectomy for penile cancer on sexual function.

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Section: Discussionmentioning

confidence: 99%

Effects of partial penectomy for penile cancer on sexual function: A systematic review

et al. 2022

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Inverted urethral flap reconstruction after partial penectomy: Long-term oncological and functional outcomes

Chavarriaga

Becerra

Camacho

et al. 2022

Urologic Oncology: Seminars and Original Investigations

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Local Therapy and Reconstruction in Penile Cancer: A Review

Zekan,

Praetzel,

Luchey

et al. 2024

Cancers

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Local therapy for penile cancer provides robust survival and can preserve the penis functionally and cosmetically. Interventions must target the appropriate clinical stage. We reviewed studies regarding the primary therapy in penile cancer, from topical therapy to radical penectomy, and reconstructive techniques. Topical therapy (5-FU or Imiquimod) provides a robust oncologic response in patients with Ta or Tis disease. Multiple laser therapies are available for localized patients and those with low-grade T1 disease. There is a non-trivial risk of progression and nodal metastases in poorly selected patients. Wide local excision provides an oncologically sound option in patient with up to T1 disease; less evidence exists for Mohs microsurgery in the setting of penile cancer. Increasingly aggressive approaches include glansectomy and partial/radical penectomy, which provide 5- and 10-year cancer-specific survival rates of over 80%. Meticulous reconstruction is necessary for the durable function of the remaining penis. Preservation of voiding and sexual function occurs via penile skin grafting, glans resurfacing, creation of a functional penile stump, and phalloplasty with a penile implant. Perineal urethrostomy provides an alternative in pathology demanding extensive partial or radical penectomy, and a durable option for seated voiding. Clinical suspicion and timely diagnosis are paramount in terms of management as less-invasive options for earlier-stage disease develop.

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Neo-glans reconstruction for penile cancer: Description of the primary technique using autologous testicular tunica vaginalis graft

Cited by 3 publications

References 11 publications

Effects of partial penectomy for penile cancer on sexual function: A systematic review

Effects of partial penectomy for penile cancer on sexual function: A systematic review

Inverted urethral flap reconstruction after partial penectomy: Long-term oncological and functional outcomes

Local Therapy and Reconstruction in Penile Cancer: A Review

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