Organ-preserving management of rhabdomyosarcoma of the prostate and bladder in children

Abstract

Between November 1978 and July 1991, ten children between one and eight years of age with Group III pelvic rhabdomyosarcoma (IRS classification) and considered inoperable at diagnosis were treated primarily with intensive poly‐chemotherapy. Complementary radiotherapy and conservative surgery were added as needed. Eight of the ten survive free of disease with functioning bladders for periods ranging from 5.7–18.4 years. Med. Pediatr. Oncol. 29:573–575, 1997. © 1997 Wiley‐Liss, Inc.

Paediatric urological malignancies

“…In a different but smaller group of 10 children with inoperable tumours, an approach with more aggressive chemotherapy was chosen, resulting in a 5.7–18.4‐year survival in eight patients [19]. Results from the Intergroup Rhabdomyosarcoma Study IV [20] suggested that ≈ 25% of patients with intermediate risk of failure and embryonal histology benefited from intensified chemotherapy.…”