Organ motion, set-up variation and treatment margins in radical radiotherapy of urinary bladder cancer

Muren, L.P.; Smaaland, Rune; Dahl, Olav

doi:10.1016/s0167-8140(03)00246-9

Cited by 168 publications

(109 citation statements)

References 38 publications

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“…The main displacement occurred in the anterior wall [33,38,40]. Also the superior half of the rectum exhibited larger variations than the inferior one [40].…”

Section: Set-up Error and Organ Motionmentioning

confidence: 89%

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IGRT in rectal cancer

Ippolito

Mertens²,

Haustermans³

et al. 2008

Acta Oncologica

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“…The main displacement occurred in the anterior wall [33,38,40]. Also the superior half of the rectum exhibited larger variations than the inferior one [40].…”

Section: Set-up Error and Organ Motionmentioning

confidence: 89%

“…In a study on bladder cancer motion, Muren et al observed that remains unclear whether the Van Herk et al recipe for CTV internal margin can be adapted to hollow organs tumours [33,34]. From literature analysis, rectal organ motion was described almost only in patients treated for prostate and bladder cancer.…”

Section: Set-up Error and Organ Motionmentioning

confidence: 99%

IGRT in rectal cancer

Ippolito

Mertens²,

Haustermans³

et al. 2008

Acta Oncologica

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“…Harris and Buchanan [7] demonstrated that 40% of patients had bladder wall movement more than 1cm, up to a maximum of 2.5cm, and that this resulted in bladder movement outside the treatment volume in 20% of cases. Bladder wall displacement of more than 15mm in 40% of patients, with a maximum displacement of up to 29-36mm was reported in one study [9] . A large variation in the urinary inflow rate among individuals was illustrated by Lotz et al [10] .…”

mentioning

confidence: 87%

“…Moreover, Meijer et al reported the need of 2cm in cranial direction, 1.0cm in the caudal, 0.7cm in the right and left directions, 0.7cm in the anterior and 1.3cm in the posterior direction [14] . On the other hand, Muren et al [9] computed these values as 2.3cm for anterior and 1.8cm for the posterior directions. It is worth noting that these margins are related to an empty bladder, as this is more reproducible and more comfortable for the patient.…”

mentioning

confidence: 99%

Re-evaluation of the value of adjunctive modern radiotherapy in muscle-invasive bladder cancer

Zaghloul

2012

JST

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A controlled prospective randomized study was recently published; comparing pre-and post-operative radiotherapy in bladder cancer patients [1] . This study was the first to compare these radical cystectomy adjunctive radiation methods. For decades left, both pre-and post-operative radiotherapy in bladder cancer had negative image for genitourinary oncologists. This unsatisfactory image was either due to insignificant improvement in the published survival rates or due to the fear of high and unacceptable late complications [2] . Abd El-Moneim et al. [1] achieved 5-year overall survival of 51% as 89% of their patients belonged to the clinical categories T3 and T4. They showed clearly that there was no difference between the 2 randomized groups; in overall survival, disease-free survival, local control and distant metastasis-free rates. It was clear from their results that both immediate postoperative complications and late serious gasterointestinal (GIT) sequalae were similar in both groups and of minimal amplitude. Late bowel complications were reported to be 4.5% in the post-operative setting and 2% in the pre-operative setting this was nearly similar to the percentages reported previously by Zaghloul et al. [3] who reported 4% and 5% grade 3+4 late bowel toxicity in conventional and hyper fractionated postoperative radiotherapy groups. In another retrospective study, a total of 12% of the patients who received PORT experienced chronic intestinal complications of different grades compared with 8% in the cystectomy alone group. There were four patients in each group (5.8% and 3.3%, respectively) that needed surgery for intestinal late complications [4] . On the other hand, much higher late GIT complications were reported by Reseinger et al. [5] . They experienced 37% late GIT complications with 22

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“…To ensure target coverage during a treatment course, CTV (i.e. bladder)-to-PTV margins of up to 25 mm have been shown to be required [1]. The large PTV volume implies unnecessary irradiation to healthy tissue and the organs at risk, mainly the rectum and intestine.…”

mentioning

confidence: 99%