Organ Damage Is Preceded by Changes in Protein Extravasation in an Experimental Model of the Multiple Organ Dysfunction Syndrome

Nieuwenhuijzen, G.; Knapen, Maarten F. C. M.; Oyen, W.J.G.; Hendriks, T.; Corstens, F.H.M.; Goris, R.J.A.

doi:10.1097/00024382-199703001-00043

Cited by 7 publications

(6 citation statements)

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“…Alterations in microcirculatory permeability are a characteristic of early tissue injury. Tissue oedema is an early indicator of tissue dysfunction prior to organ failure (30). In sepsis the adherence of leukocytes to the vascular endothelium is thought to be one of the important mechanisms responsible for an increase in vascular permeability and in oedema (33).…”

Section: Introductionmentioning

confidence: 99%

Glycoprotein IIB/IIIA‐Inhibition and Microcirculatory Alterations During Experimental Endotoxemia—An Intravital Microscopic Study in the Rat

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Glycoprotein IIB/IIIA‐Inhibition and Microcirculatory Alterations During Experimental Endotoxemia—An Intravital Microscopic Study in the Rat

et al. 2004

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“…a composite measure of permeability and vascular area available for albumin exchange) of each microvascular bed, and represented a modification of a previously established method [2]. Protocol B was designed to provide an index (PI B ) of the permeabilityisurface area product (i.e.…”

Section: Albumin Permeability Measurementsmentioning

confidence: 99%

Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase

SINGH¹,

ANNING²,

WINLOVE³

et al. 2001

Clinical Science

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Sepsis is characterized by increased microvascular permeability and regional variations in capillary perfusion, which may be modulated by nitric oxide (NO) and reversed by fluid resuscitation (FR). The effects of saline FR and NO synthase blockade [by N(G)-nitro-L-arginine methyl ester (L-NAME)] on microvascular albumin transport and perfused capillary density were assessed in anaesthetized Wistar rats with acute normodynamic endotoxaemia. Separate dual-isotope techniques were employed to measure the permeability index (PI(A)) and the permeabilityxsurface area product index (PI(B)), which provide different and complementary information regarding blood-tissue albumin exchange. PI(A) represents the tissue/blood distribution volume ratio of albumin. PI(B) is a composite measure of endothelial permeability and the vascular surface area available for albumin exchange, and therefore takes into account the effect of altered blood volume. Capillary density was quantified by fluorescence microscopy following circulation of Evans Blue-labelled albumin. Compared with controls, PI(A) was reduced significantly in lipopolysaccharide (LPS)-treated animals in skeletal muscle and skin, probably due to blood volume redistribution rather than to changes in permeability. PI(B) was increased significantly in LPS-treated animals in the kidney, mesentery, skeletal muscle, skin and lung, and in the small bowel following FR. FR also improved the LPS-induced metabolic base deficit, but did not alter capillary density. L-NAME significantly attenuated the LPS-induced rise in PI(B) in the lung. In conclusion, acute endotoxaemia induces tissue-dependent variations in microvascular albumin exchange. FR improves acid-base disturbance in endotoxaemia, through mechanisms other than microvascular recruitment. NO appears to increase microvascular permeability in endotoxaemia, an effect that may be attenuated by L-NAME, particularly in the lung.

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“…Die Interaktion zwischen dem Endothel, der Proteinkaskade, den Zytokinen und Leukozyten führt zum SIRS des Verbrennungspatienten [19]. Die frühe Durchlässigkeit des vaskulären Systems führt zur Ödembildung, zum Lungenversagen und letztlich zum Multiorganversagen [30]. Das durch die Aktivierung des Komplementsystems verursachte Kapillarleck verschlechtert zusätzlich entscheidend die hämodynamische Situation [43].…”

Section: Die Flüssigkeitssubstitutionunclassified

Der Einfluss der präklinischen Flüssigkeitssubstitution des Verbrennungspatienten auf Therapie und Verlauf im Schwerverbranntenzentrum - Eine Analyse tierexperimenteller und klinischer Daten -

Heimburg¹,

Radke²,

Wainwright³

et al. 2001

Akt Traumatol

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Organ Damage Is Preceded by Changes in Protein Extravasation in an Experimental Model of the Multiple Organ Dysfunction Syndrome

Cited by 7 publications

References 0 publications

Glycoprotein IIB/IIIA‐Inhibition and Microcirculatory Alterations During Experimental Endotoxemia—An Intravital Microscopic Study in the Rat

Glycoprotein IIB/IIIA‐Inhibition and Microcirculatory Alterations During Experimental Endotoxemia—An Intravital Microscopic Study in the Rat

Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase

Der Einfluss der präklinischen Flüssigkeitssubstitution des Verbrennungspatienten auf Therapie und Verlauf im Schwerverbranntenzentrum - Eine Analyse tierexperimenteller und klinischer Daten -

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