Orderly muscle activity in elimination of erythrocytes microrheological abnormalities in rats with experimentally developed obesity

Vatnikov, Yury Anatolyevich; S.Yu, Zavalishina; S.B, Seleznev; Kulikov, Evgeny Vladimirovich; Notina, Elena; E.O, Rystsova; A.K, Petrov; M.V, Kochneva; T.I, Glagoleva

doi:10.15562/bmj.v7i3.739

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It affects all structures of the body of living beings (Dontsov et al, 2010). The continuation of the development of biological science requires a detailed elucidation of the manifestations and mechanisms of the appearance and development of signs of aging, which is especially convenient to do during the experiment (Vatnikov et al, 2018). This is recognized as necessary for the further development of gerontology and biology (Kishkun, 2008).…”

Section: Introductionmentioning

confidence: 99%

Physiological Features of Erythrocytes in the Aging Organism

Tkacheva¹,

Медведев²,

Vorobyeva³

et al. 2023

J Biochem Technol

View full text Add to dashboard Cite

The progression of aging affects various blood parameters, which can weaken the viability of the body. Clarification of various aspects of this process requires additional observations, especially with the use of animals. The study was conducted on 43 healthy outbred male rats aged 24 months. Also, 32 healthy outbred male rats 3 months old, which formed the control group, were taken under observation. The examined 24-month-old rats showed standard aging phenomena. In their erythrocytes, there was an increase in lipid peroxidation caused by a weakening of the activity of their antioxidant defense. In the blood of two-year-old rats, there was a decrease in the level of erythrocyte-discocytes. This was accompanied in them by an excess content of erythrocytes in the blood, which had a changed shape to varying degrees. In rats of the older group, erythrocyte aggregation was increased, as indicated by an increase in the numberof erythrocytes that entered the aggregates in the blood and an increase in the number of most erythrocyte aggregates with a decrease in the level of free erythrocytes. For two-year-old rats, low content of erythrocytesdisconcytes in the blood and an excess number of erythrocytes with a modified shape, as well as an increase in their aggregation, are characteristics. An important reason for these changes is the weakening of the antioxidant protection of erythrocytes, leading to a pronounced activation of lipid peroxidation in them.

show abstract

Section: Introductionmentioning

confidence: 99%