“…Up to now, a growing amount of research has focused on the huge potential of MOFs in chromatographic stationary phases including high-performance liquid chromatography, , gas chromatography, − and capillary electrochromatography (CEC). , However, since most of the previously reported MOF-based stationary phases only have microporous (<2 nm) structures, they usually suffer from critical issues such as high mass transfer resistance, limited available interaction sites, and inaccessibility of the internal space in MOFs, which place severe limitations on the electrochromatographic separation performance . To settle these problems, an alternative way is to augment the channel sizes of MOF-based stationary phases to the mesoporous range (2–50 nm). , In our previous study, the nanoscale hierarchically porous MOFs (NHP-MOFs)-based stationary phase, NHP-UiO-66, consisting of microporous and mesoporous structures, was explored for electrochromatographic separation with remarkably improved resolution and column efficiency, benefiting from the good mass transfer performance and abundant available interaction sites of NHP materials.…”