Ordered mesoporous silica and aluminosilicate-type matrix for amikacin delivery systems

Poly(vinylidene fluoride-trifluoroethylene)/NAY zeolite hybrid membranes as a drug release platform applied to ibuprofen release

“…In recent times, many materials have been used for the production of controlled drug delivery systems, including organic polymer [6] and dendritic macromolecules [7] as well as inorganic zeolites, porous silica [8], metal-organic framework (MOF) [9] and functionalized magnetic nanoparticles [10]. Since some of these materials show the capacity to encapsulate a wide range of drugs, while others allow a better control of the drug release, its combination in hybrid inorganic-organic material is nowadays regarded as a http://dx.doi.org/10.1016/j.colsurfa.2014.12.064 0927-7757/© 2015 Elsevier B.V. All rights reserved.…”

“…This large potential use of zeolites for drug release and biomedical applications can be improved by a proper support of the zeolite particles, that can improve adhesion to specific body tissues [17] and/or tailor drug release kinetics [8]. One of the materials with large potential in this context is poly(vinylidene fluoridetrifuoroethylene), P(VDF-TrFE) [18].…”

Hybrid mesoporous silica with controlled drug release

“…28 Besides the more complex synthesis procedure, there are also drawbacks of the post-synthesis functionalization, because of the non-even coverage of the pore surfaces by the attached groups, or even blocking the pore entrances, especially in materials with relatively small pore sizes such as MCM-41. 29 In studies of mesoporous silica particles used as drug carriers, either the performance of the prepared original material is analyzed, or particles having different geometries, 16,22,26,27,29 pore sizes, 7,15,26,29 or functionalized with different molecular groups, [17][18][19][20][21]25,29 are compared. While for developing materials with the required release performance, the common approach is to find a suitable functionalization, there is a shortage of studies in which the release properties are finetuned by the continuous variation of the pore morphology or pore surface hydrophobicity.…”

“…14 Since the first demonstration by Vallet-Regí et al of using MCM-41 type mesoporous silica as drug carriers, 7 this class of materials has been extensively explored for drug loading and release properties. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The key parameters that affect the adsorption and the release of organic molecules are the particle size, the pore size, and the chemical nature of the pore surface. In order to be suitable for biomedical use the materials must be biocompatible, non-toxic, have an open ________________________________________________________________________________________________________________________ Available on line at www.shd.org.rs/JSCS/ (CC) 2019 SCS.…”

Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics

“…The detailed synthesis and characterization of MCM-41 and SBA-15 supports and metoprolol-loaded materials were reported in our previous publications [31,36]. In brief, MCM-41 was obtained by adding TEOS to an aqueous solution containing 25% ammonia and C 14 TAB.…”