Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics

Abstract

Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small-and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro release profiles have been fitted using a threeparameter kinetic model and they have been explained in terms of the release rate during the burst and sustained release stages and the fraction of drug molecules released during the burst stage. The silica framework doping with aluminum was found to decrease the amount of drug released in the burst stage, without affecting the other kinetic parameters. The therapeutic agent release rates depend mainly on the pore size and volume of the mesoporous carriers and drug-loaded samples.

Silica-Alginate Beads for Intestinal Ketoprofen Delivery

“…To get more insights on the drug transport mechanism, different kinetics models were developed [31][32][33][34][35][36]. The ketoprofen experimental release data were fitted with good correlation coefficients, R 2 w >0.95, using the Weibull model (eq.…”

Rifampicin adsorption and release study using Santa Barbara amorphous-16 modified Al (SBA-16-Al) for a drug delivery system

“…While leaving the other kinetic parameters unchanged, it was discovered that the doping of the silica nanomaterial framework with aluminum reduced the amount of drug released during the bursting stage. 26 The modification can be done using the direct-synthesis grafting method. 27 The introduction of active Al groups in mesoporous silica can increase the acidity of the material.…”