Orbital plasmacytoma as the presenting feature in multiple myeloma

Mani, Malavika; Kasturi, Nirupama; Sravya, Rekha; Kaliaperumal, Subashini; Gochhait, Debasis

doi:10.1177/1120672120929959

Cited by 8 publications

(9 citation statements)

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“…Four of the sixteen cases in our study were diagnosed with DLBCL constituting the second most prevalent NHL type. This concurs with the survey of Roositalab and Rastogi et al 12 , 14 The other possibility when there are sheets of mature plasma cells with clonality being expressed on ICC suggests a solitary plasmacytoma in the absence of marrow involvement 15 . In our study, there was one case of solitary plasmacytoma.…”

Section: Discussionsupporting

confidence: 93%

The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms

et al. 2020

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Background Orbital hematolymphoid lesions are rare and usually encountered in elderly patients. Orbital lesions are not easy to biopsy: hence fine needle aspiration cytology (FNAC) can be a very good diagnostic modality for these lesions. Materials and Methods Cases of orbital masses subjected to FNAC dating from 2013 to 2020 were retrieved from our archives. A total of 16 cases with biopsy confirmation were included. All clinical details, the type of procedure, details of the immunocytochemistry (ICC) performed on smear, follow‐up biopsy, and their haematological work‐up were analysed in detail. Results Sixteen biopsy‐confirmed cases had been diagnosed as orbital haematolymphoid lesions on cytomorphology and further categorised with ancillary studies including ICC. In twelve instances, the cytology impression was congruent with the histopathological diagnosis and eight of the sixteen cases (50%) proved to be primary orbital lymphoma. Four were secondary orbital lymphomas and the remaining four included one case each of plasmacytoma, myeloid sarcoma, Rosai‐Dorfman disease and angiolymphoid hyperplasia with eosinophilia. Conclusion FNAC is a minimally invasive procedure for diagnosing most of the haematolymphoid orbital lesions and it has a rapid turnaround time. The accuracy of cytomorphology combined with ICC on smears/cell blocks can be as good as a biopsy for exact categorisation. Additionally, aspirate smears are preferred samples for cytogenetics compared to formalin‐fixed tissue blocks, as molecular cytogenetics techniques are frequently employed for diagnostic, prognostic, and therapeutic purposes.

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Section: Discussionsupporting

confidence: 93%

The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms

et al. 2020

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“…Der Wirkmechanismus liegt einerseits in der Inhibition der Phospholipase A2 und der Zyklooxygenase sowie andererseits in einem immunsuppressiven Effekt [ 12 ]. In den wenigen beschriebenen Fallberichten wird von spontanen Rückbildungen [ 7 ], einer Kombinationstherapie von Steroiden und Chemotherapie [ 3 , 13 ] sowie gar einem akuten operativen Vorgehen mittels lateraler Kanthotomie und Kantholyse berichtet [ 6 ].…”

Section: Diskussionunclassified

“…Dazu gehören eine Sinusvenenthrombose, eine orbitale Zellulitis sowie auch orbitale oder zerebrale Raumforderungen. Pathologische Parameter, wie erhöhte Blutkörperchensenkung, CRP-Erhöhung sowie LDH-Erhöhung sind im Zusammenhang mit dem multiplen Myelom bereits beschrieben [ 13 ]. Letztlich führten klonale λ‑Leichtketten zur Diagnose des multiplen Myeloms.…”

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Bilaterale orbitale Affektion bei multiplem Myelom

et al. 2023

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“…Literature review identified a total of 111 previously reported cases in 68 articles regarding orbital involvement in patients with systemic MM (Table 2). 4,6-61…”

Section: Resultsmentioning

confidence: 99%

Orbital Involvement in Multiple Myeloma

Shoji

Chen

Topilow

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To characterize clinical and radiographic features, management, and outcomes of patients with orbital involvement of multiple myeloma (MM). Methods: A retrospective chart review identified patients with MM and orbital involvement confirmed by histopathology at a single institution between 1995 and 2021. A comprehensive literature review was performed via PubMed to identify all previously reported cases of orbital MM. Results: Retrospective review identified 7 patients (43% male, mean age 68.7 years). Presenting symptoms included proptosis and diplopia. Orbital lesions were primarily located laterally (42.8%) with associated extraocular muscle (57.1%) or lacrimal gland (42.9%) involvement. Five patients (71.4%) had a previous diagnosis of systemic MM. Six patients received chemoradiation (85.7%). All patients had improvement of orbital disease with 2 patients deceased due to disease at follow-up (mean 8.9 months). Literature review identified 111 cases (46.8% male, mean age 58.6 years). 48.6% presented with orbital disease as the first manifestation of systemic MM. Lesions were most commonly located superolaterally (20.2%) with extraocular muscle infiltration (25.2%), lacrimal gland involvement (7.2%), and orbital bony destruction (39.6%). Treatments included chemoradiation, chemotherapy, or radiation alone. Approximately half (51.4%) of patients experienced improvement in orbital disease following treatment, and 48.6% were deceased at follow-up (mean 20.1 months). Conclusions: This study provides a new retrospective study and updated comprehensive literature review regarding orbital MM. Given its poor prognosis, characterization of orbital MM is essential for early diagnosis. Orbital MM is often unilateral, located superolaterally, and may represent the first manifestation of systemic disease. Treatment includes chemotherapy and radiation, which may improve orbital disease; however, the overall prognosis remains poor.

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Orbital plasmacytoma as the presenting feature in multiple myeloma

Cited by 8 publications

References 9 publications

The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms

The utility of fine needle aspiration cytology in orbital haematolymphoid neoplasms

Bilaterale orbitale Affektion bei multiplem Myelom

Orbital Involvement in Multiple Myeloma

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