Orbital Metastasis as the Presenting Sign of Adenocarcinoma of the Breast

Glazer, Lou C.; Harris, Gerald J.; Simons, Kenneth B.

doi:10.1097/00002341-199112000-00003

Cited by 24 publications

(15 citation statements)

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“…The patient can present with 'metastatic complaints' at dif ferent phases in the evolution of her breast cancer pathology. Rarely, metastases will be found before the primary is located, when a breast cancer is found by further examination of the patient [4], Raymond et al [5] found that between 12 and 30% of the ocular metastases are the first sign in the evolution of breast cancer. In 6% of the patients of Beati et al [6], ophthal mologic metastases were the first sign of an unsuspected breast carcinoma.…”

Section: Mammakarzinom • Orbitalmetastasen • Metastasen Des Augesmentioning

confidence: 99%

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Breast Cancer and the Eye

Debois¹,

F²

1996

Oncol Res Treat

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Breast cancer has the well-known propensity to metastasize to almost any organ, giving rise to an almost unlimited variability of clinical syndromes. Ophthalmic metastases may become a part of such a pattern. Orbital and ocular metastases are not a rare event within the clinical evolution of a breast cancer, accounting for about 2-10%. Their diagnosis is usually simple and involves only clinical and noninvasive methods. Radiotherapy is the treatment of choice in most of these situations and should obviate the need for exenteration. Radiotherapy is always rewarding, enhances the comfort of the patient by preventing further loss of vision and even promotes his recuperation. Radiotherapy plays an important role in the relief of the symptoms and for the patient’s well-being. Local curability is high, but probably has no influence on the course of the metastatic disease.

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Section: Mammakarzinom • Orbitalmetastasen • Metastasen Des Augesmentioning

confidence: 99%

“…Ovarialkarzinom (2,6,8,9) Mammakarzinom (2,7,9) M Uterustumoren (8) Prostatakrebs (9) M Hodentumor (4) Kolontumoren (7,9) Leberkrebs (1,7) Hirntumoren (5) Leukämie ( …”

Section: In Der Krebstherapieunclassified

Breast Cancer and the Eye

Debois¹,

F²

1996

Oncol Res Treat

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“…In 12-31% of cases, orbits may be the first location of a neoplastic form or its dissemination (1O, [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Orbital Metastases in a Female Patient with Breast Cancer

et al. 2013

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Breast cancer is the most common malignant disease among women, with a lifetime risk of approximately 10%. Frequent and well-known locations of metastases are bone, liver, lung, skin and brain, but tumour repetition has been seen in almost any anatomic site. Orbital involvement is quite rare, or perhaps underestimated. Orbit metastases (OMs) represent 1-13% of all orbital cancers, and are difficult to discriminate with other differential diagnoses, such as a simple blepharitis, or orbital pseudotumor, up to more complex forms of cancer such as lymphoma. The prevalence of OMs is calculated to occur in 2-4.7% of primitive cancer patients. Typical manifestations of orbital metastases include overall regional inflammation, mass effect causing displacement or ocular globe proptosis, pain, bone infiltration, chemosis and eyelid swelling. Infiltration of soft tissue leads to ptosis, diplopia or enophthalmos. We report the case of a 70-year-old female patient who developed chronic inflammatory process of both orbital regions due to orbital metastases, without evidence of other systemic disease after 8 years from primary breast cancer diagnosis. The diagnostic pathway as well as the differential diagnosis are discussed.Breast cancer is the most common malignant disease among women, with a lifetime risk of approximately 10%. Men seldom develop this malignancy and represent about 1% of all cases with diagnosis of breast cancer (1). The biological properties and clinical features of breast cancer appear to be similar in both genders. Frequent and well-known locations of metastases are bone, liver, lung, skin and brain, but tumor manifestations have been seen in almost any anatomic site. Orbital involvement is quite rare, or perhaps underestimated (2).Orbit metastases (OMs) represent 1-13% of all orbital tumors and occur in 2-4.7% of patients with primitive cancer (2). Metastases of breast cancer account for the majority of ocular and orbital metastases (3,4).Typical manifestations of OMs include mass effect causing displacement or proptosis of the ocular globe, pain, inflammation, bone infiltration,

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“…Both patients have had metastatic disease for several years, and both suffered from hormonereceptor-positive tumors. Ocular metastases in male breast cancer patients have been reported in four cases (Garcia et al 1998;Schlaen and Naves 1986;Silvestris et al 2003;Stuntz et al 2000), while there is a series of reports in female breast cancer patients (Amichetti et al 2000;Bullock and Yanes 1980;Burmeister et al 1990;Ferry and Font 1974;Font and Ferry 1976;Glazer et al 1991;Jacobs and Benger 1989;Ratanatharathorn et al 1991;Reeves et al 2002;Saitoh et al 1997;Shields et al 2001;Stefanyszyn et al 1987;Toller et al 1998;van der Heijden et al 1991;Wolstencroft et al 1999). Ocular metastases are predominantly localized in the highly vascular choroids, followed by the anterior segment, other orbital structures, and the optic nerve (Ferry and Font 1974;Merrill et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…In 12-31% of the affected patients (Ferry and Font 1974;Glazer et al 1991;Reeves et al 2002;Stuntz et al 2000) eye metastases are the first sign of malignant disease or metastatic spread.…”

Section: Discussionmentioning

confidence: 99%