Breast Cancer and the Eye

Debois, J. M.; F, Haustrate

doi:10.1159/000218838

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…The median survival time of all patients with choroidal metastases is short and ranges between 4 to 12 months [5,8,12,13,17,22]. This corresponds well to our results [26].…”

Section: Discussionsupporting

confidence: 91%

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Bottke

Wiegel

Kreusel³

et al. 2005

Strahlenther Onkol

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A CCT is indicated at the diagnosis of choroidal metastases for screening of synchronous brain metastases. The incidence is about 25%, and the diagnosis of brain metastases results in a different target volume: the whole brain including the posterior parts of the eyes compared to the posterior parts of the eyes alone. Therefore, the risk of late side effects could be reduced compared with an additional later radiotherapy of the whole brain with partly overlapping fields.

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“…The median survival time of all patients with choroidal metastases is short and ranges between 4 to 12 months [5,8,12,13,17,22]. This corresponds well to our results [26].…”

Section: Discussionsupporting

confidence: 91%

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Bottke

Wiegel

Kreusel³

et al. 2005

Strahlenther Onkol

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“…In up to 80–90% of all female patients breast cancer is the primary tumour 2-4. The overall survival of these patients is poor with a median of 8–12 months for all patients and 15–17 months for patients with breast cancer 5. However, if choroidal metastasis is detected early enough, it can be treated effectively with radiation therapy, hormonal therapy, and/or chemotherapy in order to prevent loss of vision and thus maintain quality of life 3…”

mentioning

confidence: 99%

Frequency of asymptomatic choroidal metastasis in patients with disseminated breast cancer: results of a prospective screening programme

Wiegel

Kreusel

Bornfeld

et al. 1998

British Journal of Ophthalmology

103

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Aim-To determine the frequency of visually asymptomatic choroidal metastasis in patients with disseminated breast cancer and its dependence on the incidence of metastasis by number and site of other organ metastases. Methods-From January 1995 until April 1997 120 patients irradiated for disseminated breast cancer underwent ophthalmological screening for choroidal metastasis. No patient was symptomatic for ocular disease. 68 out of 120 patients were found to have metastases in one organ and 52 patients had metastases in more than one organ. 80% of the patients had bone metastases, 25% lung metastases, 22% liver metastases, 15% brain metastases, and 22% had metastases in other organs. Results-Six patients (5%) were found to have asymptomatic choroidal metastases. Five patients had unilateral and one patient bilateral metastases. 52 patients with more than one involved organ had a significantly higher risk for asymptomatic choroidal metastasis (6/52, 11%) than 68 patients with metastases in only one organ (0/68) (p=0.006). In univariate analysis a significantly higher risk was seen for patients with lung metastases (14% choroidal metastases versus 2% in patients without lung metastases, p=0.03) and for patients with brain metastases (17% choroidal metastases versus 3% in those without brain metastases, p=0.04). Conclusion-In disseminated breast cancer the incidence of asymptomatic choroidal metastases was 5% and increased to 11% when more than one organ was involved in metastatic spread. Risk factors for choroidal metastases were dissemination of disease in more than one organ and the presence of lung and brain metastases.

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“…The rate of severe late side effects after external RT of choroidal metastases is low. So far described were cataract, keratopathy, retinopathy, neovascularisation of the iris, and opticus neuropathy [5,6,21,[34][35][36][37]. Typically neither the side effects are described in most publications nor is the good tolerance of the therapy emphasized [27,35,38].…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy of Choroidal Metastases in Patients with Disseminated Cancer

Bottke

Wiegel²,

Kreusel³

et al. 2000

Oncol Res Treat

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Background: >Choroidal metastasis is the most common ocular tumor, in most cases related to breast and lung cancer. Radiotherapy (RT) mostly is the therapy of choice. However, there is a lack of data about the results of uniformly, prospective treated patients. Patients and Methods: Between November 1994 and September 1997, 37 patients with 49 metastatic eyes were enrolled into the study. 25 patients (68%) had unilateral and 12 patients (32%) had bilateral metastases. 21 patients had breast cancer as primary tumor, 12 patients lung cancer, and 4 patients other tumors. 3 patients were excluded from analysis, 34 patients with 46 involved eyes were available for analysis. 29 of those patients had symptomatic metastases, 5 patients had asymptomatic choroidal metastases. RT was performed with bi- or unilateral asymmetric fields, total dose was 40 Gy with a single dose of 2 Gy, 5 fractions per week. 12 patients (35%) had a chemotherapy following RT due to diagnosis of general tumor progression. Endpoints of the study were visual acuity (VA), local tumor control, survival, and side effects. Results: The median follow up was 6 months, 22 out of 34 patients died of metastatic disease. In 17 of symptomatic eyes (53%) an increase of VA and in 11 of symptomatic eyes (34%) a ‘no change’ was achieved. The local tumor control rate after 18 months was 83%. One patient with asymptomatic metastasis (1/14 eyes) developed symptoms until death. The median survival time was 15 months. Altogether, in 2 patients late side effects (6%) were observed (1 patients with bilateral retinopathy, 1 patient with optic nerve atrophy). Conclusions: RT with 40 Gy is highly effective in the treatment of symptomatic and asymptomatic choroidal metastases, VA was stable or improved in almost 90% of treated eyes. The rate of side effects is low.

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Breast Cancer and the Eye

Cited by 7 publications

References 31 publications

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Frequency of asymptomatic choroidal metastasis in patients with disseminated breast cancer: results of a prospective screening programme

Radiotherapy of Choroidal Metastases in Patients with Disseminated Cancer

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