Orbital Lymphoproliferative Disorders (OLPDs): Value of MR Imaging for Differentiating Orbital Lymphoma from Benign OPLDs

Haradome, K.; Haradome, Hiroki; Usui, Yoshihiko; Ueda, Shunichiro; Kwee, Thomas C.; Saito, Kazuhiro; Tokuuye, Koichi; Matsubayashi, Jun; Nagao, Toshitaka; Gotô, Hiroshi

doi:10.3174/ajnr.a3986

Cited by 80 publications

(99 citation statements)

References 23 publications

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“…Diffusion-weighted imaging (DWI) allows quantification of the diffusion properties of water molecules (4), and its derived apparent diffusion coefficient (ADC) map is widely accepted as a useful tool to detect and characterize orbital lesions (56789). Generally, due to the enlarged nuclei, hyper-cellularity, and subsequent limited extra-cellular space, malignant orbital tumors demonstrate lower ADC value than the benign tumors (5678910). However, the reproducibility of ADC measurements is still a challenge during clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion Weighted Imaging for Differentiating Benign from Malignant Orbital Tumors: Diagnostic Performance of the Apparent Diffusion Coefficient Based on Region of Interest Selection Method

et al. 2016

Korean J Radiol

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ObjectiveTo evaluate the differences in the apparent diffusion coefficient (ADC) measurements based on three different region of interest (ROI) selection methods, and compare their diagnostic performance in differentiating benign from malignant orbital tumors.Materials and MethodsDiffusion-weighted imaging data of sixty-four patients with orbital tumors (33 benign and 31 malignant) were retrospectively analyzed. Two readers independently measured the ADC values using three different ROIs selection methods including whole-tumor (WT), single-slice (SS), and reader-defined small sample (RDSS). The differences of ADC values (ADC-ROIWT, ADC-ROISS, and ADC-ROIRDSS) between benign and malignant group were compared using unpaired t test. Receiver operating characteristic curve was used to determine and compare their diagnostic ability. The ADC measurement time was compared using ANOVA analysis and the measurement reproducibility was assessed using Bland-Altman method and intra-class correlation coefficient (ICC).ResultsMalignant group showed significantly lower ADC-ROIWT, ADC-ROISS, and ADC-ROIRDSS than benign group (all p < 0.05). The areas under the curve showed no significant difference when using ADC-ROIWT, ADC-ROISS, and ADC-ROIRDSS as differentiating index, respectively (all p > 0.05). The ROISS and ROIRDSS required comparable measurement time (p > 0.05), while significantly shorter than ROIWT (p < 0.05). The ROISS showed the best reproducibility (mean difference ± limits of agreement between two readers were 0.022 [-0.080–0.123] × 10-3 mm2/s; ICC, 0.997) among three ROI methods.ConclusionApparent diffusion coefficient values based on the three different ROI selection methods can help to differentiate benign from malignant orbital tumors. The results of measurement time, reproducibility and diagnostic ability suggest that the ROISS method are potentially useful for clinical practice.

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Section: Introductionmentioning

confidence: 99%

“…However, the reproducibility of ADC measurements is still a challenge during clinical practice. Previous study has shown that ADC value can be affected by several factors, such as the magnetic field strength, MRI acquisition parameters, and also the region of interest (ROI) selection methods (10). …”

Section: Introductionmentioning

confidence: 99%

Diffusion Weighted Imaging for Differentiating Benign from Malignant Orbital Tumors: Diagnostic Performance of the Apparent Diffusion Coefficient Based on Region of Interest Selection Method

et al. 2016

Korean J Radiol

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“…Preoperative differentiation of orbital lymphoma and orbital inflammation is highly clinically relevant since treatment strategies vary substantially. Low‐dose radiation therapy is considered the first‐line treatment for orbital lymphoma, whereas patients with orbital inflammation undergo corticosteroid therapy …”

mentioning

confidence: 99%

“…In addition, standard magnetic resonance imaging (MRI) cannot permit the differentiation of orbital lymphoma and orbital inflammation, because they both appear as isointense or hypointense on T 1 ‐ and T 2 ‐weighted images. Moreover, both of them show moderate enhancement after injection of gadolinium‐based MR contrast agents . Haradome et al suggested that orbital inflammation often presented "flow void sign," but the characteristics of standard MRI are not reliable.…”

mentioning

confidence: 99%

Lymphoma and inflammation in the orbit: Diagnostic performance with diffusion‐weighted imaging and dynamic contrast‐enhanced MRI

Sun

Song

Wang

et al. 2016

Magnetic Resonance Imaging

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“…The lower ADC is thought to reflect higher cellularity in orbital lymphoma. 20 Infections, such as orbital cellulitis, can be difficult to discriminate from IOP; however, a search for adjacent sinus disease, particularly within the ethmoid sinus, and early abscess formation would facilitate the diagnosis. In cases where IOP has a more diffused and infiltrative morphology, the diagnosis may be more challenging;…”

Section: Idiopathic Orbital Pseudotumormentioning

confidence: 99%

MRI in the Evaluation of Acute Visual Syndromes

Mukhi

Lincoln²

2015

Topics in Magnetic Resonance Imaging

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Acute visual symptom emergencies occur commonly and present a challenge to both clinical and radiologic facets. Although most patients with visual complaints routinely require clinical evaluation with direct ophthalmologic evaluation, imaging is rarely necessary. However, there are highly morbid conditions where the prompt recognition and management of an acute visual syndrome (AVS) requires an astute physician to probe further. Suspicious symptomatology including abrupt visual loss, diplopia, ophthalmoplegia, and proptosis/exophthalmos require further investigation with advanced imaging modalities such as magnetic resonance imaging and magnetic resonance angiography. This review will discuss a variety of AVSs including orbital apex syndrome, cavernous sinus thrombosis, cavernous carotid fistula, acute hypertensive encephalopathy (posterior reversible encephalopathy syndrome), optic neuritis, pituitary apoplexy including hemorrhage into an existing adenoma, and idiopathic intracranial hypertension. A discussion of each entity will focus on the clinical presentation, management and prognosis when necessary and finally, neuroimaging with emphasis on magnetic resonance imaging. The primary purpose of this review is to provide an organized approach to the differential diagnosis and typical imaging patterns for AVSs. We have provided a template for radiologists and specialists to assist in early intervention in order to decrease morbidity and provide value-based patient care through imaging.

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Orbital Lymphoproliferative Disorders (OLPDs): Value of MR Imaging for Differentiating Orbital Lymphoma from Benign OPLDs

Cited by 80 publications

References 23 publications

Diffusion Weighted Imaging for Differentiating Benign from Malignant Orbital Tumors: Diagnostic Performance of the Apparent Diffusion Coefficient Based on Region of Interest Selection Method

Diffusion Weighted Imaging for Differentiating Benign from Malignant Orbital Tumors: Diagnostic Performance of the Apparent Diffusion Coefficient Based on Region of Interest Selection Method

Lymphoma and inflammation in the orbit: Diagnostic performance with diffusion‐weighted imaging and dynamic contrast‐enhanced MRI

MRI in the Evaluation of Acute Visual Syndromes

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