Orbital Inflammatory Disease After Pamidronate Treatment for Metastatic Prostate Cancer

Subramanian, Prem S.

doi:10.1001/archopht.121.9.1335

Cited by 39 publications

(18 citation statements)

References 4 publications

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“…On a much smaller scale, bisphosphonates have been shown to cause ocular inflammation, such as anterior uveitis, conjunctivitis episcleritis, and scleritis, 151 and orbital inflammation in a small number of cases. [152][153][154][155][156][157][158][159][160][161][162][163][164] Bisphosphonates are primarily used for the treatment of osteoporosis. The use of bisphosphonates is increasing partly because of the increased use of aromatase inhibitors for the treatment of hormone-receptor-positive breast cancer in women and androgen-deprivation therapy for prostate cancer in men, which results in a reduction of bone-density.…”

Section: Bisphosphonate-induced Orbital Inflammationmentioning

confidence: 99%

Sex Disparities in Neuro-Ophthalmologic Disorders

Chen

Costello

Kardon

2014

Current Eye Research

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Many neuro-ophthalmic diseases have a clear sex predilection, which is important to recognize in making the diagnosis based on risk stratification and understanding the pathogenesis of the disease. This review discusses the more common neuro-ophthalmic diseases with a female predilection, including idiopathic intracranial hypertension, cerebral venous sinus thrombosis, meningioma, multiple sclerosis, migraine, breast-cancer associated neuro-ophthalmic manifestations, sarcoidosis, bisphosphonate-associated orbital inflammation, and pregnancy-related neuro-ophthalmic disorders. In addition, the male predominance in the clinical manifestation of Leber's Hereditary Optic Neuropathy is discussed. Lastly, the etiology of the sex discrepancies for each disease is explored.

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Section: Bisphosphonate-induced Orbital Inflammationmentioning

confidence: 99%

Sex Disparities in Neuro-Ophthalmologic Disorders

Chen

Costello

Kardon

2014

Current Eye Research

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“…Orbital inflammation including orbital myositis can be caused by bisphosphonates (Fraunfelder & Fraunfelder, 2003;Philips & Newman, 2008;Seth, et al, 2009;Sharma et al, 2008;Subramanian et al, 2003) and also by influenza vaccine (Thurairajan et al, 1997). Physicians should aware of these rare orbital conditions.…”

Section: Orbital Inflammation Triggered By Drugsmentioning

confidence: 99%

Orbital Myositis

Kubota

2011

Idiopathic Inflammatory Myopathies - Recent Developments

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“…The cases of three patients who developed IOI after administration of intravenous bisphosphonates have been reported 8 23. The proposed mechanism of action is the release of the inflammatory cytokines IL-1 and IL-6 triggered by bisphosphonates.…”

Section: Commentmentioning

confidence: 99%

“…Many case reports and series have highlighted possible etiological factors for IOI, including autoimmune diseases7 and medications such as bisphosphonates,8 lithium9 and chemotherapeutics 10. Retroperitoneal fibrosis is a systemic disease entity that is similar in many respects to IOI 11.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for idiopathic orbital inflammation: a case-control study

Bijlsma

Gils

Paridaens

et al. 2010

British Journal of Ophthalmology

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Objective To identify risk factors involved in the development of idiopathic orbital inflammation (IOI). Methods Caseecontrol study of 69 adults who had had a first episode of IOI and 296 adult controls with rhegmatogenous retinal detachment (RD) selected from three orbital centres in The Netherlands between 2000 and 2006. Participants filled out a questionnaire on demographic factors, medical history, health status and exposures for the 2 years prior to disease presentation. In addition, women were questioned about previous or current pregnancies and their hormonal status. ORs and accompanying 95% CIs for IOI in relation to potential risk factors such as body mass index (BMI), bisphosphonates and autoimmune disease were estimated. ORs were adjusted for age, sex, socio-economic status, smoking and blunt orbital trauma using logistic regression. Analyses were carried out both with and without multiple imputation of missing values. Results The risk of IOI was increased in participants who had a higher BMI (third vs first tertile: OR, 2.88; 95% CI 1.32 to 6.32) and in participants who used bisphosphonates (OR 8.68; 95% CI 1.16 to 65.0). The risk was decreased in participants with a higher socioeconomic status (third vs first tertile: OR 0.38; 95% CI 0.17 to 0.84) and in women who were older at first childbirth (third vs first tertile: OR 0.14; 95% CI 0.03 to 0.64). An almost significant association was found for IOI and autoimmune disease (OR 2.56; 95% CI 0.93 to 7.05). Conclusions IOI is associated with lower socioeconomic status, higher BMI and use of oral bisphosphonates. In women, IOI is also associated with younger age at first childbirth.

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Orbital Inflammatory Disease After Pamidronate Treatment for Metastatic Prostate Cancer

Abstract: A randomized trial of topical cyclosporin 0.05% in steroidresistant atopic keratoconjunctivitis. Ophthalmology. In press.

Cited by 39 publications

References 4 publications

Sex Disparities in Neuro-Ophthalmologic Disorders

Sex Disparities in Neuro-Ophthalmologic Disorders

Orbital Myositis

Risk factors for idiopathic orbital inflammation: a case-control study

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