Orbital Extension of Choroidal and Ciliary Body Melanomas

Uveal melanoma: management and outcome of patients with extraocular spread

“…This figure is in line with previous observations, reporting a frequency between 6.2% and 14.6% in enucleated eyes5–7 18–20 and between 2.8 and 5.4% in patients treated by proton-beam radiotherapy 11…”

“…In enucleated patients, recurrences are nonetheless observed in about 6% with postoperative irradiation of the orbit25 and 22% without 5 7. Within our study none of the enucleated patients developed a tumour recurrence.…”

Uveal melanoma: management and outcome of patients with extraocular spread

“…This figure is in line with previous observations, reporting a frequency between 6.2% and 14.6% in enucleated eyes5–7 18–20 and between 2.8 and 5.4% in patients treated by proton-beam radiotherapy 11…”

“…In enucleated patients, recurrences are nonetheless observed in about 6% with postoperative irradiation of the orbit25 and 22% without 5 7. Within our study none of the enucleated patients developed a tumour recurrence.…”

Adjuvant External Beam Radiotherapy Following Enucleation of Eyes With Extraocular Extension From Uveal Melanoma

“…6 In support of this, many older studies have found the size of EOE to be prognostically irrelevant. 5,10,12,30 Our extremely poor 10-year survival outcome of 12% is in keeping with American Joint Committee on Cancer survival estimates based on the large size of intraocular tumors included in this study (mean largest basal diameter and thickness: 18.5 ± 6.0 mm and 9.2 ± 4.2 mm, respectively) and the presence of EOE.…”

Intravascular Presence of Tumor Cells as Prognostic Parameter in Uveal Melanoma: A 35-Year Survey

“…In several articles, advanced age has been associated with a larger basal diameter, non-spindle-cell type and extrascleral extension, all of which are known prognostic factors for melanoma-related death. [33][34][35][36] This was also the case in our study (data not shown). As tumor size and non-spindle-cell type were both clearly related to the presence of intravascular tumor cell ingrowth, which may explain the observed correlation with old age.…”

Uveal melanoma: management and outcome of patients with extraocular spread

“…This figure is in line with previous observations, reporting a frequency between 6.2% and 14.6% in enucleated eyes5–7 18–20 and between 2.8 and 5.4% in patients treated by proton-beam radiotherapy 11…”

“…In enucleated patients, recurrences are nonetheless observed in about 6% with postoperative irradiation of the orbit25 and 22% without 5 7. Within our study none of the enucleated patients developed a tumour recurrence.…”

Adjuvant External Beam Radiotherapy Following Enucleation of Eyes With Extraocular Extension From Uveal Melanoma

“…6 In support of this, many older studies have found the size of EOE to be prognostically irrelevant. 5,10,12,30 Our extremely poor 10-year survival outcome of 12% is in keeping with American Joint Committee on Cancer survival estimates based on the large size of intraocular tumors included in this study (mean largest basal diameter and thickness: 18.5 ± 6.0 mm and 9.2 ± 4.2 mm, respectively) and the presence of EOE.…”

Intravascular Presence of Tumor Cells as Prognostic Parameter in Uveal Melanoma: A 35-Year Survey

“…In several articles, advanced age has been associated with a larger basal diameter, non-spindle-cell type and extrascleral extension, all of which are known prognostic factors for melanoma-related death. [33][34][35][36] This was also the case in our study (data not shown). As tumor size and non-spindle-cell type were both clearly related to the presence of intravascular tumor cell ingrowth, which may explain the observed correlation with old age.…”

Uveal melanoma: management and outcome of patients with extraocular spread

“…This figure is in line with previous observations, reporting a frequency between 6.2% and 14.6% in enucleated eyes5–7 18–20 and between 2.8 and 5.4% in patients treated by proton-beam radiotherapy 11…”

“…In enucleated patients, recurrences are nonetheless observed in about 6% with postoperative irradiation of the orbit25 and 22% without 5 7. Within our study none of the enucleated patients developed a tumour recurrence.…”

Adjuvant External Beam Radiotherapy Following Enucleation of Eyes With Extraocular Extension From Uveal Melanoma

“…6 In support of this, many older studies have found the size of EOE to be prognostically irrelevant. 5,10,12,30 Our extremely poor 10-year survival outcome of 12% is in keeping with American Joint Committee on Cancer survival estimates based on the large size of intraocular tumors included in this study (mean largest basal diameter and thickness: 18.5 ± 6.0 mm and 9.2 ± 4.2 mm, respectively) and the presence of EOE.…”

Intravascular Presence of Tumor Cells as Prognostic Parameter in Uveal Melanoma: A 35-Year Survey

“…In several articles, advanced age has been associated with a larger basal diameter, non-spindle-cell type and extrascleral extension, all of which are known prognostic factors for melanoma-related death. [33][34][35][36] This was also the case in our study (data not shown). As tumor size and non-spindle-cell type were both clearly related to the presence of intravascular tumor cell ingrowth, which may explain the observed correlation with old age.…”