Magnetic Resonance Imaging of a Canine Eye with Melanoma

Kato, Koichi; Nishimura, Ryohei; Sasaki, Nobuo; Matsunaga, Satoru; Mochizuki, Manabu; Nakayama, Hiroyuki; Ogawa, Hiroyuki

doi:10.1292/jvms.67.179

Cited by 20 publications

(12 citation statements)

References 10 publications

(16 reference statements)

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“…(9) Similar to human uveal melanoma, MRI of canine intraocular melanoma are hyperintense on T1-weighted image, and hypointense on T2-weighted image due to the presence of melanin. (25) Gadoliniumdiethylenetriamine-penta-acetic acid dimeglumine (Ga-DTPA) enhanced imaging should not be used because it creates an irregular enhancement of the ciliary body. (25) Exfoliative cytology may be used with tumors involving the eyelids, conjunctiva, nictitating membrane, cornea, and sclera.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

“…(25) Gadoliniumdiethylenetriamine-penta-acetic acid dimeglumine (Ga-DTPA) enhanced imaging should not be used because it creates an irregular enhancement of the ciliary body. (25) Exfoliative cytology may be used with tumors involving the eyelids, conjunctiva, nictitating membrane, cornea, and sclera. (2) Fine needle aspiration of uveal masses is usually nondiagnostic.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

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Melanocytic Ophthalmic Neoplasms of the Domestic Veterinary Species: A Review

Wang

Kern

2015

Topics in Companion Animal Medicine

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Section: Diagnostic Evaluationmentioning

confidence: 99%

Section: Diagnostic Evaluationmentioning

confidence: 99%

Melanocytic Ophthalmic Neoplasms of the Domestic Veterinary Species: A Review

Wang

Kern

2015

Topics in Companion Animal Medicine

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“…MR images of melanoma masses are characterized by high signal intensity on T1-weighted images and low signal intensity on T2-weighted images due to the presence of melanin [5,8]. In the present case, signal intensity of the lesion on T2-weighted images was low probably because of a large amount of pigments within the tumor cells.…”

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confidence: 50%

Choroidal Melanoma in a Dog

Miwa

Matsunaga

Kato

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. A 7-year-old intact female golden Retriever was referred for evaluation of an intraorbital mass of the left eye. Based on ophthalmoscopy, ultrasonography and magnetic resonance imaging (MRI), the tentative diagnosis was made as an intraocular neoplasia, especially choroidal melanoma. The orbital exenteration of the affected eye was performed. The mass was histologically diagnosed as malignant choroidal melanoma. No signs of recurrence and metastasis were detected by thoracic radiographs, blood examinations and MR images, and the dog was clinically healthy for 23 months after operation. KEY WORDS: canine, choroidal melanoma, magnetic resonance imaging (MRI).J. Vet. Med. Sci. 67(8): 821-823, 2005 Melanomas are the most common primary ocular tumor in dogs, although primary ocular tumors are relatively rare [1]. Most of primary melanomas in dogs arise from the anterior uveal tract such as the iris and ciliary body [1,4,11], and primary choroidal melanoma is less common among primary ocular melanomas [2,9]. Previous studies documented 4% of canine ocular melanomas to be of the choroidal origin and the behavioral and cytologic features were benign [3,11]. Another report on benign choroidal melanoma in a dog showed that the tumor lesion did not change for 7 years, similar to that of human uveal nevus [10]. But the other case of canine choroidal melanoma with metastasis was reported [4]. The present paper describes ophthalmoscopy, magnetic resonance imaging (MRI), histopathology and a 23-month follow up of a choroidal melanoma in a dog.A 7-year-old intact female golden Retriever was referred to Veterinary Medical Center (VMC) at the University of Tokyo for evaluation of an intraorbital mass of the left eye. Two months prior to referral, the owner noticed the blindness of the left eye of the dog and admitted to a practitioner. Opthalmic examinations revealed mydriasis and loss of menace reflex and direct pupilary light reflex in the left eye. Consensual pupilary light reflex was lost in the right eye. Then the patient was referred to another practitioner to examine the cause of the vision loss of the left eye, where the black pigmented and edematous retina around the optic nerve disk were found on ophthalmoscopy and diagnosed as inflammation of the nerve disk. The dog was treated with the taper dose of prednisone with an initial dose of 2 mg/kg/ day. Two weeks later, the dog received ophthalmoscopy and was revealed that the edematous area was reduced but the black-pigmented area was enlarged and rose up toward the vitreous. Ultrasonogram of the affected eye revealed the solid mass lesion which overlaying the optic disk area. Then the dog was referred to VMC for the detail evaluation of the solid mass by MRI.On physical examination, the dog was clinically normal. Complete blood count and blood chemistry revealed no abnormal findings. On ophthalmic examination, the menace reflex and the pupilary light reflex were lost as seen in the practitioners. The intraocular pressure was within the normal range in both ey...

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“…The previous diagnosis of glaucoma in cases of ocular melanocytic tumour may be normal as showed in some publications (Hyman and others 2002, Kato and others 2005). Clinical presentation includes glaucoma, hyphema, anterior uveitis and retinal detachment in addition to the presence of a proliferative lesion.…”

Section: Discussionmentioning

confidence: 91%

“…These procedures are highly indicated in cases with histopathological parameters suggestive of malignancy (Donaldson and others 2006) because the reported decreased survival in dogs with primary intraocular melanoma is in contrast to the dogma that these tumours are of little clinical significance beyond their effects on the eye (Giuliano and others 1999). Imaging characteristics of the tumour have been described employing magnetic resonance (Kato and others 2005, Miwa and others 2005). In this case, only CT images were obtained when the neurological sings appeared.…”

Section: Discussionmentioning

confidence: 99%

Presumed primary uveal melanoma with brain extension in a dog

Galán

Martín-Suárez

Molleda

et al. 2009

J of Small Animal Practice

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A 13-year-old, female, mixed, cocker spaniel was examined for a unilateral exophthalmia and protruding mass in episcleral region of the right eye. Mode B ocular ultrasonography revealed a mass extended intraocular from anterior chamber to posterior pole without evidence of extraocular extension. A presumptive diagnosis of melanocytic tumour was made. A complete blood count and chemistry and thoracic radiographs did not show any abnormal changes. The recommended treatment was enucleation, and melanocytic nature of the tumour was confirmed by immunohistochemistry. Three months after surgery, the animal showed a status epilepticus refractory to treatment. Computed tomographic examination of the brain revealed changes compatible with a tumour. Cerebrospinal fluid analysis was normal. Because of the poor clinical prognosis, the owners elected to have the dog euthanased.

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Magnetic Resonance Imaging of a Canine Eye with Melanoma

Cited by 20 publications

References 10 publications

Melanocytic Ophthalmic Neoplasms of the Domestic Veterinary Species: A Review

Melanocytic Ophthalmic Neoplasms of the Domestic Veterinary Species: A Review

Choroidal Melanoma in a Dog

Presumed primary uveal melanoma with brain extension in a dog

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