Orbital complications of sinusitis in children in Komfo Anokye Teaching Hospital

Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

“…[2] The pathophysiology of ARS is complex with a dominant role of inflammatory mucosal swelling, confining of natural sinus ostia in the area of ostiomeatal complex and sphenoethmoidal recess, and impaired mucociliary transport. [3] Viral infections disturb the function of ciliated cells of the pseudostratified respiratory epithelium, leading to mucociliary clearance impairment. This results in increase of cytokine and chemokine production, neutrophil chemoattraction, and bradykinin and leukotrienes releases.…”

“…Transudation and mucosal gland secretion accumulation within the sinuses favor the development of bacteria which release toxins to develop inflammation, leading to a cruel circle effect. [3] Antibiotics are the most common treatment agents in ARS. However, as ARS is mostly a viral disease, the moderate benefits of antibiotics should be weighed against associated risks such as allergic reactions, gastrointestinal diseases and the development of resistant bacterial germs.…”