Orbital cavernous hemangiomas

Herter, Th.; Bennefeld, Harald; Brandt, Matthias

doi:10.1007/bf01794679

Cited by 13 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the orbit, they represent 80% of adult angiomatous malformations, accounting for 9.5% to 15% of primary orbital expanding masses [1,5]. Orbital cavernomas have been reported to appear with symptoms at an average age of 42 years, ranging from 18 to 67 years [6]. Intracranial and orbital cavernous hemangiomas in children, especially in infants, are rare [4].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of cerebral cavernous malformations in children is estimated to be between 0.37% and 0.53% [7]. Multiple lesions in a single orbital cavity or simultaneously occurring in both orbits have been reported, while a familial form of orbital cavernous angiomas have also been described [6,8]. The incidence of familial cerebral cases has been estimated to be close to 20% in the literature, and the pattern of inheritance is consistent with an autosomal dominant mode with incomplete clinical penetration and possible de novo mutation [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Orbital cavernous hemangioma in an infant with intracranial lesions: a case report

Evagelidou

Tsanou

Asproudis

et al. 2009

Cases J

View full text Add to dashboard Cite

IntroductionCavernous hemangiomas of the orbit are benign vascular malformations, commonly encountered in adults. Although they are infrequent in pediatric population their diagnosis and course are of a great significance, mainly because they can cause visual disturbances such as amblyopia that can ensue, and secondarily due to their cosmetic and psychological effect. Special attention is required in follow up and treatment. Additionally, a systemic evaluation is necessary in order to discover asymptomatic lesions elsewhere in the body carrying a risk of complications.Case presentationThe authors describe the clinical course, diagnosis, therapeutic approach and prognosis of an infant with an orbital cavernous hemangioma accompanying intracranial lesions. A female infant 18 months of age, presented with a mass in the left upper eyelid, causing blepharoptosis. Preoperative magnetic resonance imaging and angiography of the brain and the orbits showed a hemangioma of the left upper eyelid and intracranial lesions to the left temporal fossa and the pons. At the age of 2 years and 8 months she was admitted again due to severe eyelid swelling, intense strong pain, exophthalmos and collateral ophthalmoplegia. Two operations were performed to remove the orbit mass. Histological examination, showed characteristics of cavernous hemangioma.ConclusionThe atypical presentation of cavernous orbital hemangioma with early infantile onset, merits attention.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Orbital cavernous hemangioma in an infant with intracranial lesions: a case report

Evagelidou

Tsanou

Asproudis

et al. 2009

Cases J

View full text Add to dashboard Cite

show abstract

“…Although the significance of steroid receptors in mesenchymal tumors is unclear, it has been suggested that the growth of some of these tumors may be hormone dependent [14,48]. Cases of hemangioma [8, 12,27,33,34,37,39] and angioleiomyoma [22] in which pain presented or increased in intensity during pregnancy or in the course of the menstrual cycle have been reported in several sites, one of which is the orbit [24,25,51].…”

Section: Introductionmentioning

confidence: 97%

“…Orbital cavernous hemangiomas (OCH) are lesions of middle age (mean age at onset of symptoms is 40 years), mainly affecting women [1,5,20,24,31,40]. They constitute 7-16% of orbital lesions according to different authors and have a typical clinical presentation characterized by slowly developing proptosis, diplopia, reduction of visual acuity and restriction of the visual field [5,20,31].…”

Section: Introductionmentioning

confidence: 99%

Progesterone receptor expression in orbital cavernous hemangiomas

et al. 2000

View full text Add to dashboard Cite

Orbital cavernous hemangiomas (OCH) have thick and highly cellular vascular walls. Ultrastructural studies have demonstrated the smooth muscle nature of these cells. Vascular neoplasms can modify their morphological and clinical features under hormonal stimulation. The purpose of the present study was to investigate the presence of smooth muscle markers and sex steroid receptors in 12 cases of OCH. Orbital cases were compared with cutaneous hemangiomas and subcutaneous angioleiomyomas. Smooth muscle actin (SMA) and desmin were localized in spindle cells of the vascular walls of all 12 cases studied. OCH showed immunohistochemical positivity with progesterone receptor (PR) antibody both in smooth muscular and in endothelial cells. For comparison, sex steroid receptors were studied in 10 cases of cutaneous cavernous hemangioma and in 10 cases of subcutaneous angioleiomyoma. PR was found in smooth muscle and endothelial cells of 6 out of 10 cases of subcutaneous angioleiomyoma and in none of the cases of cutaneous cavernous hemangioma. No positivity was obtained with estrogen receptor (ER) antibody in any of the cases tested. The present data suggest that OCH share morphological and immunohistochemical features with subcutaneous angioleiomyomas. Furthermore, immunohistochemical positivity with PR antibody indicates that OCH have to be added to the list of mesenchymal lesions that express sex steroid receptors.

show abstract

“…1,3,6,11,19,24) Orbital CHs account for 7-16% of orbital lesions and the typical clinical presentation is characterized by slowly developing proptosis, diplopia, reduction of visual acuity, and restriction of the visual field. 3,6,19) These findings suggest that orbital CH grows slowly.…”

Section: Introductionmentioning

confidence: 99%

Growth Potential of Orbital Cavernous Hemangioma Suggested by Vascular Endothelial Growth Factor and its Receptor Flk-1

Nagasaka

Naganuma

Satoh

2007

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Orbital cavernous hemangiomas (CHs) manifest as slowly developing symptoms indicative of slow growth. The present study investigated the involvement of angiogenic factors and their receptors in the growth of orbital CHs. Surgical specimens of orbital CHs were obtained from nine patients. Formalinfixed, paraffin-embedded specimens were stained immunohistochemically using antibodies against Ki-67, CD31, a-smooth muscle actin (a-SMA), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and VEGF receptors (flt-1 and flk-1). CD31 was expressed in the single layer of endothelial cells lining the vascular cavity. The thick vascular walls were positive for a-SMA, indicating that the vascular walls were smooth muscle cells. Ki-67 antigen immunostaining was mostly positive in the vascular walls and the staining index ranged from 0% to 6.8% (mean ± standard deviation, 2.7 ± 1.9%). VEGF and bFGF immunostaining were positive in all specimens. Flt-1 immunostaining was negative in all specimens, but flk-1 immunostaining was positive in both endothelial cells and smooth muscle cells. These results suggest that both VEGF and its receptor flk-1 are important in the growth of orbital CH.

show abstract

Orbital cavernous hemangiomas

Cited by 13 publications

References 8 publications

Orbital cavernous hemangioma in an infant with intracranial lesions: a case report

Orbital cavernous hemangioma in an infant with intracranial lesions: a case report

Progesterone receptor expression in orbital cavernous hemangiomas

Growth Potential of Orbital Cavernous Hemangioma Suggested by Vascular Endothelial Growth Factor and its Receptor Flk-1

Contact Info

Product

Resources

About