Progesterone receptor expression in orbital cavernous hemangiomas

Tommaso, Luca Di; Scarpellini, F; Salvi, Fabrizio; Ragazzini, T; Foschini, Maria Pia

doi:10.1007/s004280050042

Cited by 50 publications

(38 citation statements)

References 39 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Progesterone receptors may influence angioleiomyoma development. 13,16) In the present case, the tumor showed negativity for both progesterone receptors and estrogen receptors. On cytogenetic studies, angioleiomyomas have near-diploid karyotypes, but no consistent abnormalities have been detected.…”

Section: )supporting

confidence: 45%

Angioleiomyoma of the Nasal Septum: A Case Report

Choi

Kim

2008

Yeungnam Univ J Med

View full text Add to dashboard Cite

-AbstractAngioleiomyoma of the sinonasal tract is a rare benign tumor. We report a case of angioleiomyoma of the nasal septum in a 51-year-old woman who complained of frequent epistaxis for 3 months. Surgicalexcision was performed. The excised specimen was 0.7 × 0.5 × 0.4 cm in size, well circumscribed, grayish white, rubbery, and soft. Histological examination showed thick-walled blood vessels and smooth muscle cell proliferation. No nuclear atypia or mitoses were present.

show abstract

Section: )supporting

confidence: 45%

Angioleiomyoma of the Nasal Septum: A Case Report

Choi

Kim

2008

Yeungnam Univ J Med

View full text Add to dashboard Cite

show abstract

“…This role has previously been reported in other anatomic locations, especially during pregnancy or in the course of the menstrual cycle. [13][14][15] However, one should keep in mind that in our case, another factor contributing to the volume reduction of the small mass might have been the removal of the 4 14-gauge cores.…”

Section: Discussionmentioning

confidence: 92%

Cavernous hemangioma of the breast: Mammographic and sonographic findings and follow‐up in a patient receiving hormone‐replacement therapy

Mesurolle

Wexler

Halwani

et al. 2003

J of Clinical Ultrasound

View full text Add to dashboard Cite

We report the case of a 78-year-old woman who had been receiving hormone-replacement therapy (HRT) for 6 years and had a 4-month history of a painless nodule in the 9 o'clock position in her right breast. Mammography performed 4 years previously had shown a 4-mm bilobed, ovoid, well-defined nodule in that location; mammography performed 1 year previously had shown that the nodule had increased to 6 mm. We performed mammographic and sonographic examinations, which revealed a 10-mm ovoid nodule in the same 9 o'clock position in the right breast. The imaging findings appeared to indicate benignity, but because of the increasing size of the nodule, we undertook an ultrasound-guided large-core needle biopsy. The histopathologic diagnosis was typical cavernous hemangioma. It was not excised, but HRT was discontinued. Follow-up mammography and sonography 8 months later showed that the nodule had decreased to 6 mm. We believe that the HRT played a contributory role in the increasing size of this patient's cavernous hemangioma. The use of ultrasound-guided large-core needle biopsy is reliable enough to ascertain the benignity of such masses and can thus avoid, if it is clinically appropriate, the need for their surgical removal.

show abstract

“…This suggests that the vascular wall mainly consists of proliferated smooth muscle cells. 5) In fact, Ki-67 antigen was expressed mostly in the smooth muscle cells, indicating the growth potential of the smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

“…Progesterone receptor is present in orbital CHs and may be related to the growth of orbital CHs. 5,13,29) The growth of orbital CHs may be hormone dependent, since some orbital CHs grow during pregnancy, 28) suggesting another mechanism controlling the growth of orbital CHs.…”

Section: Discussionmentioning

confidence: 99%

Growth Potential of Orbital Cavernous Hemangioma Suggested by Vascular Endothelial Growth Factor and its Receptor Flk-1

Nagasaka

Naganuma

Satoh

2007

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Orbital cavernous hemangiomas (CHs) manifest as slowly developing symptoms indicative of slow growth. The present study investigated the involvement of angiogenic factors and their receptors in the growth of orbital CHs. Surgical specimens of orbital CHs were obtained from nine patients. Formalinfixed, paraffin-embedded specimens were stained immunohistochemically using antibodies against Ki-67, CD31, a-smooth muscle actin (a-SMA), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and VEGF receptors (flt-1 and flk-1). CD31 was expressed in the single layer of endothelial cells lining the vascular cavity. The thick vascular walls were positive for a-SMA, indicating that the vascular walls were smooth muscle cells. Ki-67 antigen immunostaining was mostly positive in the vascular walls and the staining index ranged from 0% to 6.8% (mean ± standard deviation, 2.7 ± 1.9%). VEGF and bFGF immunostaining were positive in all specimens. Flt-1 immunostaining was negative in all specimens, but flk-1 immunostaining was positive in both endothelial cells and smooth muscle cells. These results suggest that both VEGF and its receptor flk-1 are important in the growth of orbital CH.

show abstract

Progesterone receptor expression in orbital cavernous hemangiomas

Cited by 50 publications

References 39 publications

Angioleiomyoma of the Nasal Septum: A Case Report

Angioleiomyoma of the Nasal Septum: A Case Report

Cavernous hemangioma of the breast: Mammographic and sonographic findings and follow‐up in a patient receiving hormone‐replacement therapy

Growth Potential of Orbital Cavernous Hemangioma Suggested by Vascular Endothelial Growth Factor and its Receptor Flk-1

Contact Info

Product

Resources

About