Orange and blue luminescence emission to track functionalized porous silicon microparticles inside the cells of the human immune system

Daldosso, N.; Ghafarinazari, A.; Cortelletti, Paolo; Marongiu, Laura; Donini, Marta; Paterlini, Veronica; Bettotti, Paolo; Guider, R.; Froner, E.; Dusi, Stefano; Scarpa, Marina

doi:10.1039/c4tb01031k

Cited by 14 publications

(15 citation statements)

References 51 publications

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“…At the end of this procedure, microparticles with pore size about 20-30 nm, bearing Si-H groups on the surface are produced. [28] Light-driven hydrosilylation by acrylic acid in toluene at 50 • C under mild stirring (two hours) has been performed to introduce COOH groups at the porous surface. The obtained solution was washed (10 min centrifugation and removal of the supernatant) several times in ethanol and stored in this solvent.…”

Section: Psi Fabrication and Carboxyl Functionalizationmentioning

confidence: 99%

“…[29] However, some oxidation occurs and some SiO x groups are present as shown by FTIR spectra. [28] SPIONs (Super Paramagnetic Iron Oxide-Fe 3 O 4 -Nanoparticles) were purchased from Sigma-Aldrich, St. Louis, MO, USA (concentration: 5 mg•mL −1 in water, magnetization > 25 emu•g −1 at 4500 Oe, average particle size: 5-7 nm) and diluted in PBS to perform the experiments. We chose phosphate-buffered saline (PBS, pH 7.4) as a solvent in perspective of in-vitro tests.…”

Section: Psi Fabrication and Carboxyl Functionalizationmentioning

confidence: 99%

“…With these experimental findings, we set up a protocol to get positively charged SPIONs to the pSi-COOH microparticles, whose morphology and porosity have been carefully characterized in previously published works. [14,28] The resulting sample (namely pSi-SPIONs microparticles) was dispersed in PBS.…”

Section: Spions Characterization and Functionalizationmentioning

confidence: 99%

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Porous Si Microparticles Infiltrated with Magnetic Nanospheres

et al. 2020

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Porous silicon (pSi) microparticles obtained by porosification of crystalline silicon wafers have unique optical properties that, together with biodegradability, biocompatibility and absence of immunogenicity, are fundamental characteristics to candidate them as tracers in optical imaging techniques and as drug carriers. In this work, we focus on the possibility to track down the pSi microparticles also by MRI (magnetic resonance imaging), thus realizing a comprehensive tool for theranostic applications, i.e., the combination of therapy and diagnostics. We have developed and tested an easy, quick and low-cost protocol to infiltrate the COOH-functionalized pSi microparticles pores (tens of nanometers about) with magnetic nanospheres (SPIONs—Super Paramagnetic Iron Oxide Nanoparticles, about 5–7 nm) and allow an electrostatic interaction. The structural properties and the elemental composition were investigated by electron microscopy techniques coupled to elemental analysis to demonstrate the effective attachment of the SPIONs along the pores’ surface of the pSi microparticles. The magnetic properties were investigated under an external magnetic field to determine the relaxivity properties of the material and resulting in an alteration of the relaxivity of water due to the SPIONs presence, clearly demonstrating the effectiveness of the easy functionalization protocol proposed.

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Section: Psi Fabrication and Carboxyl Functionalizationmentioning

confidence: 99%

Section: Psi Fabrication and Carboxyl Functionalizationmentioning

confidence: 99%

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Porous Si Microparticles Infiltrated with Magnetic Nanospheres

et al. 2020

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“…[7][8][9][10][11] Moreover, well assessed fabrication protocols produce pSi microparticles with intense photoluminescence (PL) in the visible region, which can be tracked in cells by uorescence imaging in real time. 12,13 Another promising application of pSi for medicine is photo-thermal therapy, which is based on absorption of light and on its transformation to heat in order to kill the target (cell, tissue). 14 These properties make pSi particles based systems particularly suitable for both therapy and diagnosis of diseases, allowing for real-time monitoring of the therapeutic efficacy and for a reduction of drugs administration, which are the basis of the novel and promising eld of "theranostic".…”

Section: Introductionmentioning

confidence: 99%

Hybrid luminescent porous silicon for efficient drug loading and release

et al. 2017

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“…When the surface of Si‐nc is functionalized, Si‐nc preserve their emission properties and can be used as biomarkers or as chromophores in bioimaging experiments. More interestingly, drugs can be drafted on the Si‐nc surface and released in specific compartments that makes them a traceable drug‐delivery system . Sensitization action: Si‐nc can be used as a sensitizer of other active emission centers . A typical example is the coupled system of Er ions and Si‐nc.…”

Section: Introductionmentioning

confidence: 99%

Silicon nanocrystals for nonlinear optics and secure communications

Bisadi

Mancinelli

Manna

et al. 2015

Physica Status Solidi (a)

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Silicon nanocrystals (Si‐nc) are reviewed here for their interesting optical applications. On the one hand, they do exhibit quantum confinement effects. This allows turning silicon into a light‐emitting material where luminescence can be excited by electrical injection. On the other hand, small sizes, large surfaces, and dielectric mismatch between the core and the surrounding matrix increase dramatically the nonlinear optical coefficients. This allows using Si‐nc as a nonlinear material in different waveguide configurations. In this paper, we discuss specifically two different applications of Si‐nc: (i) as a nonlinear material in various devices, e.g., in bistable optical cavities, in waveguide optical mode monitors that are based on two‐photon excited luminescence detection, and in wavelength shifters by using four‐wave mixing (FWM); (ii) as an entropy source for quantum random number generation, the key device for cryptography. (a) Top view optical image of a Si‐nc‐based whispering‐gallery mode (WGM) microdisk resonator, vertically coupled with a bus waveguide. (b) Detail of the coupling zone. (c) Normalized waveguide transmission spectrum over a wide spectral range. The inset shows a blow up of a resonance with the radial and azimuthal mode orders and the Q factor value indicated.

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Orange and blue luminescence emission to track functionalized porous silicon microparticles inside the cells of the human immune system

Cited by 14 publications

References 51 publications

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Hybrid luminescent porous silicon for efficient drug loading and release

Silicon nanocrystals for nonlinear optics and secure communications

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